公开(公告)号：US20220192998A1

公开(公告)日：2022-06-23

申请号：US17603163

申请日：2020-04-09

Applicant: DSM IP ASSETS B.V.

Inventor： Elger FUNDA ,  Odile KRAINZ ,  Robert STEINERT

IPC: A61K9/50 ,  A61K31/202 ,  A61K9/48

Abstract: The present invention relates to a new delivery system for PUFAs.

公开(公告)号：US20220288103A1

公开(公告)日：2022-09-15

申请号：US17271998

申请日：2019-08-28

Applicant: DSM IP ASSETS B.V.

Inventor： Maaike Johanna BRUINS ,  Sophie FEHLBAUM ,  Thanh-Van PHAM ,  Kevin PRUDENCE ,  Robert STEINERT ,  Pietro CELI ,  Gilberto LITTA ,  Estefania PEREZ CALVO ,  Wilbert SYBESMA

IPC: A61K31/714 ,  A61K31/07 ,  A61K31/525 ,  A61K31/375 ,  A61K31/593 ,  A61K31/122 ,  A61K31/519 ,  A61K31/015 ,  A61K31/51 ,  A61K31/455 ,  A61K31/197 ,  A61K31/4415 ,  A61K31/4188 ,  A61K31/202 ,  A61K31/355 ,  A61P1/14

Abstract: Various benefits to intestinal health are made by delivery of an active agent to the colon of an animal, including a human. Active ingredients include of riboflavin, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, β-carotene, vitamin B1, niacin, vitamin B5, vitamin B6, biotin, vitamin B12, omega-3 fatty acids and combinations thereof. Benefits include increased concentration of at least one short-chain fatty acid its salt thereof in the intestine, increased microbiome diversity in the intestine, increased beneficial bacteria in the intestine, increased the butyrate synthesis pathway in the intestine, improved barrier function of the intestine, reduced redox potential of the gut, reduced amount of gas produced in the intestine; and stimulation of intestinal immune responses.

公开(公告)号：US20220193033A1

公开(公告)日：2022-06-23

申请号：US17606817

申请日：2020-04-09

Applicant: DSM IP ASSETS B.V.

Inventor： Elger FUNDA ,  Odile KRAINZ ,  Robert STEINERT

IPC: A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/519 ,  A61K31/714 ,  A61K9/50

Abstract: The present invention relates to a new delivery system for specific water-soluble vitamins.

公开(公告)号：US20240148739A1

公开(公告)日：2024-05-09

申请号：US18550642

申请日：2022-03-17

Applicant: DSM IP Assets B.V.

Inventor： Thanh-Van PHAM ,  Ateequr REHMAN ,  Nicole SEIFERT ,  Robert STEINERT ,  Wilbert SYBESMA

IPC: A61K31/525 ,  A61K31/015 ,  A61K31/355 ,  A61K31/375 ,  A61P31/04

CPC classification number: A61K31/525 ,  A61K31/015 ,  A61K31/355 ,  A61K31/375 ,  A61P31/04

Abstract: Delivery of antioxidants (Vitamin C, Vitamin E, riboflavin, and beta-carotene) directly to the large intestine were seen to decrease the population of Fusobacterium in the gut microbiome. An increased population of these bacteria is associated with Fusobacterium bacteremia as a co-morbidity with any one of: malignancy, dementia, chronic obstructive lung disease, diabetes, heart disease, alcoholism, disease(s) requiring dialysis, and stroke; colorectal cancer; digestive diseases including Ulcerative colitis; Crohn's disease; and/or Pediatric or adult inflammatory bowel disease; colorectal and other cancers, inflammatory bowel disease, adverse pregnancy-related conditions, and HIV.

公开(公告)号：US20240016748A1

公开(公告)日：2024-01-18

申请号：US18250377

申请日：2021-10-26

Applicant: DSM IP ASSETS B.V.

Inventor： Thanh-Van PHAM ,  Ateequr REHMAN ,  Robert STEINERT ,  Wilbert SYBESMA

IPC: A61K9/28 ,  A61K31/375 ,  A61K31/4415 ,  A61K31/525 ,  A61K31/455 ,  A61K31/197 ,  A61P31/04 ,  A61K9/48

CPC classification number: A61K9/2866 ,  A61K31/375 ,  A61K31/4415 ,  A61K31/525 ,  A61K31/455 ,  A61K31/197 ,  A61P31/04 ,  A61K9/4891

Abstract: This invention relates to the direct delivery of a vitamin composition to the large intestine, in order to decrease the growth of pathogenic organisms in the gut, such as Adherent Invasive E. coli (AIEC), Salmonella enteriditis and Clostridium difficile. The vitamin composition comprises a combination of the following vitamins: Vitamin C, Vitamin B2, Vitamin B3, Vitamin B5, Vitamin B6 and folic acid.

公开(公告)号：US20230270705A1

公开(公告)日：2023-08-31

申请号：US18014780

申请日：2021-07-08

Applicant: DSM IP ASSETS B.V.

Inventor： Thanh-Van PHAM ,  Ateequr REHMAN ,  Nicole SEIFERT ,  Robert STEINERT ,  Wilbert SYBESMA

IPC: A61K31/202 ,  A61K31/07 ,  A61K31/375 ,  A61K31/525 ,  A61K31/015 ,  A61K31/197 ,  A61K31/122 ,  A61K31/593 ,  A61P1/00

CPC classification number: A61K31/202 ,  A61K31/07 ,  A61K31/375 ,  A61K31/525 ,  A61K31/015 ,  A61K31/197 ,  A61K31/122 ,  A61K31/593 ,  A61P1/00

Abstract: The population of Dialister spp. bacteria in the gut microbiome is lower in people with various diseases. We have found that administration of vitamins/vitamin combinations such as: beta-carotene, Vitamin A, Vitamin D, Vitamin B5, Vitamin B2, a combination of Vitamin B2 and Vitamin C, Vitamin K, DHA, or EPA, when administered directly to the large intestine, so that it provides nourishment to the gut microbiome directly, can result in an increase of Dialister spp.

公开(公告)号：US20220135667A1

公开(公告)日：2022-05-05

申请号：US17427823

申请日：2020-02-04

Applicant: RIJSUNIVERSITEIT GRONINGEN ,  DSM IP ASSETS B.V. ,  ACADEMISCH ZIEKENHUIS GRONINGEN

Inventor： Gerard DIJKSTRA ,  Klaas Nico FABER ,  Hermanus Jozef Martinus HARMSEN ,  Robert STEINERT ,  Wilbert SYBESMA ,  Araksya TOPCHYAN

IPC: C07K16/24 ,  A61P29/00 ,  A61K31/525 ,  A61P1/00

Abstract: The present invention relates to pharmaceutical combinations of at least one TNF inhibitor and riboflavin to treat patients suffering from inflammatory bowel disease (IBD) or other inflammatory conditions (such as rheumatoid arthritis, ankylosing spondylitis, psoriasis, lupus erythematous and multiple sclerosis). This invention also relates to additive and/or combinations of at least one TNF inhibitor and riboflavin. This invention is also related to a method for the treatment or prophylaxis of IBD, which method comprises administering a therapeutically effective amount of TNF inhibitor and riboflavin.

公开(公告)号：US20210177766A1

公开(公告)日：2021-06-17

申请号：US16761053

申请日：2018-10-30

Applicant: DSM IP ASSETS B.V.

Inventor： Elger FUNDA ,  Odile KRAINZ ,  Robert STEINERT

IPC: A61K9/50 ,  A61K9/28 ,  A61K9/48 ,  A61K9/20 ,  A23K40/30 ,  A23K20/174 ,  A23L33/15 ,  A23P10/30 ,  A23P20/10 ,  A61K8/11 ,  A61K8/67

Abstract: The present invention relates to a new delivery system for nutritional ingredients (nutraceuticals). These nutritional ingredients are useful for gut and metabolic health in monogastric animals, especially in humans.

公开(公告)号：US20240148738A1

公开(公告)日：2024-05-09

申请号：US18548797

申请日：2022-03-03

Applicant: DSM IP Assets B.V.

Inventor： Thanh-Van PHAM ,  Ateequr REHMAN ,  Robert STEINERT ,  Wilbert SYBESMA

IPC: A61K31/525 ,  A61K31/015 ,  A61K31/355 ,  A61K31/375 ,  A61P1/14

CPC classification number: A61K31/525 ,  A61K31/015 ,  A61K31/355 ,  A61K31/375 ,  A61P1/14

Abstract: The direct delivery of antioxidant compounds (Vitamin B2, Vitamin C, beta-carotene, and Vitamin E) to the large intestine results in an increase in the population of Blautia spp. in the gut. People with lower amounts of Blautia spp. often experience obesity, insulin resistance and chronic inflammation, major depressive disorder as well as other conditions which can be helped by increasing their population of Blautia. An increase in the population of Blautia also increases the amount of beneficial short chain fatty acids in the intestine as well.

公开(公告)号：US20230404970A1

公开(公告)日：2023-12-21

申请号：US18250811

申请日：2021-10-27

Applicant: DSM IP ASSETS B.V.

Inventor： Thanh-Van PHAM ,  Ateequr REHMAN ,  Robert STEINERT ,  Wilbert SYBESMA

IPC: A61K31/375 ,  A61K31/4415 ,  A61K31/525 ,  A61K31/455 ,  A61K31/197 ,  A61P1/00 ,  A61K9/00

CPC classification number: A61K31/375 ,  A61K31/4415 ,  A61K31/525 ,  A61K31/455 ,  A61K31/197 ,  A61P1/00 ,  A61K9/0053

Abstract: This invention relates to the direct delivery to the intestine of a vitamin composition to restore a balanced population and metabolic profile of gut microbiome bacteria which has been disrupted due to exposure to antibiotics. The vitamin composition may comprise Vitamin C as a sole active agent; Vitamin C in combination with Vitamin B2 and/or B3; or Vitamin C in combination with Vitamin B2, Vitamin B3, Vitamin B5, Vitamin B6 and Vitamin B9.