公开(公告)号：US20150376113A1

公开(公告)日：2015-12-31

申请号：US14848269

申请日：2015-09-08

Applicant: DSM IP ASSETS B.V.

Inventor： Stephane DUVAL ,  Maik KINDERMANN

IPC: C07C207/04 ,  C07C207/02 ,  A61K31/04 ,  C07C311/24 ,  A61K31/18 ,  C07C255/11 ,  A61K31/275 ,  A61K31/22 ,  A61K31/24 ,  C07D493/04 ,  A61K31/34 ,  C07D213/82 ,  A61K31/4406 ,  A61K31/08 ,  A23K1/16 ,  A23K1/18 ,  A61K31/045

CPC classification number: C07C203/04 ,  A23K20/10 ,  A23K20/105 ,  A23K20/111 ,  A23K20/121 ,  A23K50/10 ,  A61K31/04 ,  A61K31/045 ,  A61K31/08 ,  A61K31/18 ,  A61K31/21 ,  A61K31/216 ,  A61K31/22 ,  A61K31/24 ,  A61K31/275 ,  A61K31/34 ,  A61K31/345 ,  A61K31/4406 ,  A61K45/06 ,  C07C207/02 ,  C07C207/04 ,  C07C255/11 ,  C07C311/03 ,  C07C311/24 ,  C07D213/82 ,  C07D307/72 ,  C07D493/04 ,  Y02P60/56

Abstract: The present invention relates to a method for reducing the production of methane emanating from the digestive activities of a ruminant and/or for improving ruminant animal performance by using, as active compound at least one organic molecule substituted at any position with at least one nitrooxy group, or a salt thereof, which is administrated to the animal together with the feed. The invention also relates to the use of these compounds in feed and feed additives such as premix, concentrates and total mixed ration (TMR) or in the form of a bolus.

Abstract translation: 本发明涉及通过使用至少一个有机分子在至少一个硝基氧基取代的有机分子作为活性化合物，减少由反刍动物的消化活性产生的甲烷和/或改善反刍动物性能的方法 ，或其盐，其与饲料一起施用于动物。 本发明还涉及这些化合物在饲料和饲料添加剂如预混物，浓缩物和总混合比例（TMR）中或在丸剂形式中的用途。

公开(公告)号：US20250098709A1

公开(公告)日：2025-03-27

申请号：US18954372

申请日：2024-11-20

Applicant: DSM IP Assets B.V.

Inventor： Stephane DUVAL ,  Maik KINDERMANN ,  Sarah Jade MEALE ,  Diego Pablo MORGAVI

IPC: A23K20/105 ,  A23K50/10

Abstract: The present invention relates to a method of reducing methane emissions in ruminants, said method encompassing treating pre-/young ruminants with 3-nitrooxypropanol.

公开(公告)号：US20250073253A1

公开(公告)日：2025-03-06

申请号：US18949971

申请日：2024-11-15

Applicant: DSM IP Assets B.V.

Inventor： Britta BLOKKER ,  Stephane DUVAL ,  John Michael GEREMIA ,  Estefania PEREZ CALVO ,  Nathalie RICHARD ,  Jerome SCHMEISSER ,  Nicole SEIFERT ,  Viviane VERLHAC

IPC: A61K31/702 ,  A23K20/163 ,  A23K50/30 ,  A23K50/75 ,  A61K9/00 ,  A61P1/00

Abstract: Methods of feeding animals are disclosed whereby feed additives are provided that modulate the gut microbiome to prevent or treat dysfunctions in a gastrointestinal barrier. The present disclosure further relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat infections.

公开(公告)号：US20170105958A1

公开(公告)日：2017-04-20

申请号：US15390374

申请日：2016-12-23

Applicant: DSM IP ASSETS B.V.

Inventor： Stephane DUVAL ,  Irmgard IMMIG ,  Maik KINDERMANN ,  Gilbert WEBER

IPC: A61K31/21 ,  A61K31/22 ,  A61K31/235 ,  A61K31/34 ,  A61K31/4406 ,  A23K20/195 ,  A61K31/23 ,  A61K45/06 ,  A61K9/00 ,  A61K31/35 ,  A23K50/10 ,  A23K20/10 ,  A61K31/275 ,  A61K31/215

CPC classification number: A61K31/21 ,  A23K20/10 ,  A23K20/105 ,  A23K20/195 ,  A23K50/10 ,  A61K9/0053 ,  A61K31/04 ,  A61K31/215 ,  A61K31/22 ,  A61K31/221 ,  A61K31/23 ,  A61K31/235 ,  A61K31/24 ,  A61K31/255 ,  A61K31/275 ,  A61K31/34 ,  A61K31/35 ,  A61K31/351 ,  A61K31/44 ,  A61K31/4406 ,  A61K45/06 ,  Y02P60/56

Abstract: Methane emission in ruminants is reduced by the use of a feed composition or a feed additive comprising at least one antibiotic and at least one organic molecule substituted at any position with at least one nitrooxy group.

公开(公告)号：US20140134282A1

公开(公告)日：2014-05-15

申请号：US14159576

申请日：2014-01-21

Applicant: DSM IP ASSETS B.V.

Inventor： Stephane DUVAL ,  Maik KINDERMANN

IPC: C07C203/04 ,  A61K45/06 ,  A23K1/18 ,  A61K31/215 ,  A23K1/16 ,  A61K31/21 ,  C07C235/06

CPC classification number: C07C203/04 ,  A23K20/105 ,  A23K20/174 ,  A23K50/10 ,  A61K31/21 ,  A61K31/215 ,  A61K45/06 ,  C07C235/06 ,  Y02P60/56

Abstract: The present invention relates to a method for reducing the production of methane emanating from the digestive activities of a ruminant and or for improving ruminant animal performance by using, as active compound at least one nitrooxy alkanoic acid and/or derivative thereof, which is administrated to the animal together with the feed. The invention also relates to the use of these compounds in feed and feed additives such as premix, concentrates and total mixed ration (TMR) or in the form of a bolus.

Abstract translation: 本发明涉及一种通过使用至少一种硝基氧基链烷酸和/或其衍生物作为活性化合物来降低由反刍动物的消化活性产生的甲烷的产生和/或用于改善反刍动物性能的方法。 动物与饲料一起。 本发明还涉及这些化合物在饲料和饲料添加剂如预混物，浓缩物和总混合比例（TMR）中或在丸剂形式中的用途。

公开(公告)号：US20220192229A1

公开(公告)日：2022-06-23

申请号：US17603195

申请日：2020-04-14

Applicant: DSM IP ASSETS B.V.

Inventor： Stephane DUVAL ,  Maik KINDERMANN ,  Sarah Jade MEALE ,  Diego Pablo MORGAVI

IPC: A23K20/105 ,  A23K50/10

Abstract: The present invention relates to a method of reducing methane emissions in ruminants, said method encompassing treating pre-/young ruminants with 3-nitrooxypropanol.

公开(公告)号：US20220000891A1

公开(公告)日：2022-01-06

申请号：US17291481

申请日：2019-11-08

Applicant: DSM IP Assets B.V. ,  Midori USA, Inc.

Inventor： Britta BLOKKER ,  Stephane DUVAL ,  John Michael GEREMIA ,  Estefania PEREZ CALVO ,  Nathalie RICHARD ,  Jerome SCHMEISSER ,  Nicole SEIFERT ,  Viviane VERLHAC

IPC: A61K31/702 ,  A61K9/00 ,  A61P1/00 ,  A23K20/163 ,  A23K50/75 ,  A23K50/30

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat dysfunctions in a gastrointestinal barrier. The present disclosure further relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat infections.

公开(公告)号：US20160183564A1

公开(公告)日：2016-06-30

申请号：US14910383

申请日：2014-07-31

Applicant: DSM IP ASSETS B.V.

Inventor： Stephane DUVAL ,  Maik KINDERMANN

IPC: A23K1/16 ,  A61K31/135

CPC classification number: A23K20/105 ,  A23K20/111 ,  A23K20/121 ,  A23K20/132 ,  A23K20/137 ,  A23K50/10 ,  Y02P60/56

Abstract: The present invention relates to the field of reduction of methane emission in ruminants. Particularly, it relates to the a feed composition or a feed additive, and the use of said feed composition or a feed additive comprising at least one para nitroaniline derivative or a salt thereof and at least one organic molecule substituted at any position with at least one nitrooxy group for reducing the production of methane emanating from the digestive activities of ruminants, and/or to improve the ruminant performance.

Abstract translation: 本发明涉及反刍动物甲烷排放减少的领域。 特别地，本发明涉及饲料组合物或饲料添加剂，以及所述饲料组合物或含有至少一种对硝基苯胺衍生物或其盐的饲料添加剂和至少一种在任何位置被至少一个取代的有机分子的用途 硝基氧基，用于减少从反刍动物的消化活性产生的甲烷的产生，和/或提高反刍动物的性能。

公开(公告)号：US20240293437A1

公开(公告)日：2024-09-05

申请号：US18420540

申请日：2024-01-23

Applicant: DSM IP Assets B.V.

Inventor： Stephane DUVAL ,  John Michael GEREMIA ,  Lisa Ann LAPRADE ,  April WAGUESPACK-LEVY ,  Estefania PEREZ CALVO ,  Ghislain SCHYNS ,  Viviane VERLHAC ,  Joshua Thomas CLAYPOOL

IPC: A61K31/702 ,  A23K20/163 ,  A23K50/30 ,  A23K50/75

CPC classification number: A61K31/702 ,  A23K20/163 ,  A23K50/30 ,  A23K50/75

Abstract: Methods of feeding animals are disclosed wherein providing feed additives are provided that modulate the gut microbiome to improve the health, nutrition, and growth performance. Methods of modulating the microbial species present in the gastrointestinal tract of an animal are also disclosed. Such modulation includes, for example, modulating the level or function of microbial species.

公开(公告)号：US20210393658A1

公开(公告)日：2021-12-23

申请号：US17292132

申请日：2019-11-08

Applicant: DSM IP Assets B.V. ,  Midori USA, Inc.

Inventor： Stephane DUVAL ,  John Michael GEREMIA ,  Lisa Ann LAPRADE ,  April Waguespack LEVY ,  Estefania PEREZ CALVO ,  Ghislain SCHYNS ,  Viviane VERLHAC ,  Joshua CLAYPOOL

IPC: A61K31/702 ,  A23K20/163 ,  A23K50/75 ,  A23K50/30

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating the microbial species present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level or function of microbial species.