公开(公告)号：US4405373A

公开(公告)日：1983-09-20

申请号：US106132

申请日：1979-12-21

Applicant: Lawrence B. Kool ,  Robert L. Nolen ,  David E. Solomon

Inventor： Lawrence B. Kool ,  Robert L. Nolen ,  David E. Solomon

IPC: B01J13/04 ,  C08J3/12 ,  C08J3/21 ,  H02K44/08 ,  C08L1/08 ,  C08J3/04

CPC classification number: B01J13/043 ,  C08J3/122 ,  C08J3/21 ,  H02K44/08 ,  Y10S264/06

Abstract: A method of adjustably tailoring the effective bulk density of a solid material in which a mixture comprising the solid material, a film-forming polymer and a volatile solvent are sprayed into a drying chamber such that the solvent evaporates and the polymer dries into hollow shells having the solid material captured within the shell walls. Shell density may be varied as a function of solid/polymer concentration, droplet size and drying temperature.

Abstract translation: 一种可调节地调节固体材料的有效堆积密度的方法，其中将包含固体材料，成膜聚合物和挥发性溶剂的混合物喷射到干燥室中，使得溶剂蒸发并将聚合物干燥成具有 捕获在壳壁内的固体物质。 壳体密度可以随着固体/聚合物浓度，液滴尺寸和干燥温度的变化而变化。

公开(公告)号：US06214618B1

公开(公告)日：2001-04-10

申请号：US09287793

申请日：1999-04-07

Applicant: William J. Hillegas ,  David E. Solomon ,  Gilbert H. Wuttke

Inventor： William J. Hillegas ,  David E. Solomon ,  Gilbert H. Wuttke

IPC: C12N500

CPC classification number: C12N5/0075 ,  C12N11/08 ,  C12N2533/30

Abstract: There is provided a method of making microcarrier beads having the steps of forming a bead made of a lightly crosslinked styrene copolymer core and also having functional groups on the surface of the bead and washing the microcarrier beads with basic and acidic solutions to make the beads compatible for cell culture. Also provided is a microcarrier bead made of a styrene copolymer core with a tri-methylamine exterior which has been washed in basic and acidic solutions to make the beads compatible for cell culture. The method of using microcarrier beads for increased growth of anchorage dependent cells having the steps of washing the microcarrier bead with basic and acidic solutions and mixing the microcarrier bead with an anchorage dependent cell containing culture medium is also provided.

Abstract translation: 提供了一种制备微载体珠粒的方法，该方法具有以下步骤：形成由轻度交联的苯乙烯共聚物核心制成的珠粒，并且还在珠粒表面上具有官能团并用碱性和酸性溶液洗涤微载体珠粒以使珠粒相容 用于细胞培养。 还提供了由具有三甲胺外部的苯乙烯共聚物核心制成的微载体珠粒，其已经在碱性和酸性溶液中洗涤以使珠粒与细胞培养物相容。 还提供了使用微载体珠增加锚定依赖细胞生长的方法，所述细胞具有用碱性和酸性溶液洗涤微载体珠粒并将微载体珠粒与含有锚定依赖性细胞的培养基混合的步骤。

公开(公告)号：US4829004A

公开(公告)日：1989-05-09

申请号：US124699

申请日：1987-11-24

Applicant: James Varani ,  David E. Solomon ,  William J. Hillegas ,  David L. Melmoth

Inventor： James Varani ,  David E. Solomon ,  William J. Hillegas ,  David L. Melmoth

IPC: C12M3/04

CPC classification number: C12M27/12 ,  C12M25/16 ,  C12M27/20 ,  C12M27/22

Abstract: An insert for a roller bottle of the type used in cell culture for vaccine manufacture is formed of a polymeric resilient material whereby it can be bent or rolled so that it can pass through the opening of the roller bottle. Once the insert is inside the bottle, it is released so that its resilient characteristic causes it to unbend or unroll. The insert is wider than the diameter of the roller bottle, and therefore it is urged against the interior wall of the roller bottle. Apertures and/or notches are provided in the insert to increase the turbulence of a fluid and to decrease the fluidic shear forces in the roller bottle as it is rotated in conventional operation. A significant increase in productivity is achieved because particles, which may be microcarrier beads, are maintained in suspension, and prevented from sinking to the bottom of the fluid medium where cells cannot grow. The roller bottle system is thereby transformed into a microcarrier suspension culture system.

Abstract translation: 用于疫苗制造的细胞培养用类型的滚瓶的插入物由聚合物弹性材料形成，由此可以弯曲或滚动，使得其可以穿过滚瓶的开口。 一旦插入物在瓶子内部，它被释放，使得其弹性特性使其不弯曲或展开。 插入件比滚瓶的直径宽，因此它被推靠在滚瓶的内壁上。 在插入件中设置孔和/或凹口以增加流体的湍流并且在常规操作中旋转时降低滚瓶中的流体剪切力。 实现了生产率的显着提高，因为可以是微载体珠的颗粒保持悬浮状态，并且防止其下沉到细胞不能生长的流体介质的底部。 由此将滚瓶系统转化为微载体悬浮培养系统。

公开(公告)号：US4432933A

公开(公告)日：1984-02-21

申请号：US675530

申请日：1976-04-09

Applicant: Robert J. Teitel ,  David E. Solomon

Inventor： Robert J. Teitel ,  David E. Solomon

IPC: H05H1/22 ,  H05H6/00 ,  G21B1/00 ,  G21C3/04

CPC classification number: G21B1/19 ,  H05H6/00 ,  Y02E30/16 ,  Y10S376/916

Abstract: In processes utilizing a source of laser energy for achieving a thermonuclear fusion reaction, it is necessary to have fusion fuel prepared in a configuration with minute dimensions and the present invention contemplates preparing this fuel by introducing into hollow microspheres (typically comprised of glass) of predetermined size, in the range of 250 to 2,000 micrometers, a gaseous thermonuclear fuel. One way of accomplishing this is to cause diffusion of gaseous thermonuclear fuel through the walls of the microsphere under conditions of suitable temperature and pressure so that it may be achieved in a reasonable time, after which the fuel can be frozen out on the walls of the microsphere to provide a fusion fuel in a hollow spherical shape. Suitable coatings of additional materials may be applied to the fueled microsphere by appropriate coating methods to complete complex thermonuclear fuel pellet configurations.

Abstract translation: 在利用激光能源来实现热核聚变反应的方法中，需要以微小的尺寸制备具有构型的熔融燃料，并且本发明考虑通过将具有预定的方式引入中空微球（通常由玻璃构成）来制备该燃料 尺寸在250至2,000微米的范围内，气态热核燃料。 实现这一点的一种方法是在合适的温度和压力的条件下使气态热核燃料扩散通过微球的壁，使得其可以在合理的时间内实现，之后燃料可以在 微球以提供中空球形的融合燃料。 可以通过适当的涂覆方法将适当的附加材料涂层施加到燃料微球体上以完成复杂的热核燃料丸粒构型。

公开(公告)号：US4055276A

公开(公告)日：1977-10-25

申请号：US541447

申请日：1975-01-16

Applicant: David E. Solomon

Inventor： David E. Solomon

IPC: G21F5/002 ,  B67B7/24

CPC classification number: G21F5/002

Abstract: A container for the storage, shipping and dispensing of hydrogen isotopes such as hydrogen, deuterium, tritium, or mixtures of the same which has compactness, which is safe against fracture or accident, and which is reusable. The container consists of an outer housing with suitable inlet and outlet openings and electrical feed elements, the housing containing an activated sorber material in the form, for example, of titanium sponge or an activated zirconium aluminate cartridge. The gas to be stored is introduced into the chamber under conditions of heat and vacuum and will be retained in the sorber material. Subsequently, it may be released by heating the unit to drive off the stored gas at desired rates.

Abstract translation: 用于储存，运输和分配氢同位素如氢，氘，氚或其混合物的容器，其具有紧凑性，其对于断裂或事故是安全的，并且是可重复使用的。 容器由具有合适的入口和出口开口的外壳以及供电元件组成，该外壳包含例如钛海绵或活化的铝酸铝盒形式的活化的吸附剂材料。 要储存的气体在热和真空条件下被引入到室中，并保留在吸附剂材料中。 随后，可以通过加热该单元以按所需的速率排出储存的气体来释放它。

公开(公告)号：US4021253A

公开(公告)日：1977-05-03

申请号：US463892

申请日：1974-04-05

Applicant: Ronald G. Budrick ,  Frank T. King ,  Robert L. Nolen, Jr. ,  David E. Solomon

Inventor： Ronald G. Budrick ,  Frank T. King ,  Robert L. Nolen, Jr. ,  David E. Solomon

IPC: C03C3/00 ,  C03C11/00 ,  C03C12/00 ,  C03C3/04

CPC classification number: C03C11/002 ,  C03C12/00 ,  C03C3/00 ,  Y10S376/916 ,  Y10S65/901

Abstract: A method of manufacturing a glass frit for use in the manufacture of uniform glass microspheres to serve as containers for laser fusion fuel to be exposed to laser energy which includes the formation of a glass gel which is then dried, pulverized, and very accurately sized to particles in a range of, for example, 125 to 149 micrometers. The particles contain an occluded material such as urea which expands when heated. The sized particles are washed, dried, and subjected to heat to control the moisture content prior to being introduced into a system to form microspheres.

Abstract translation: 一种制造用于制造均匀玻璃微球的玻璃料的方法，用作用于暴露于激光能量的激光熔化燃料的容器，其包括形成玻璃凝胶，然后干燥，粉碎并非常精确地定尺寸至 例如在125至149微米的范围内的颗粒。 颗粒中含有诸如尿素的封闭材料，其在加热时膨胀。 将大小的颗粒洗涤，干燥并进行加热以控制水分含量，然后再将其导入系统以形成微球体。

公开(公告)号：US4017290A

公开(公告)日：1977-04-12

申请号：US463860

申请日：1974-04-15

Applicant: Ronald G. Budrick ,  Frank T. King ,  Alfred J. Martin ,  Robert L. Nolen, Jr. ,  David E. Solomon

Inventor： Ronald G. Budrick ,  Frank T. King ,  Alfred J. Martin ,  Robert L. Nolen, Jr. ,  David E. Solomon

IPC: C03B19/10 ,  H05H1/22 ,  C03B19/08

CPC classification number: G21B1/19 ,  C03B19/1075 ,  Y02E30/16

Abstract: A method and apparatus for making uniform pellets for laser driven fusion reactors which comprises selection of a quantity of glass frit which has been accurately classified as to size within a few micrometers and contains an occluded material, such as urea, which gasifies and expands when heated. The sized particles are introduced into an apparatus which includes a heated vertical tube with temperatures ranging from 800.degree. C to 1300.degree. C. The particles are heated during the drop through the tube to molten condition wherein the occluded material gasifies to form hollow microspheres which stabilize in shape and plunge into a collecting liquid at the bottom of the tube. The apparatus includes the vertical heat resistant tube, heaters for the various zones of the tube and means for introducing the frit and collecting the formed microspheres.

Abstract translation: 一种用于制造用于激光驱动的聚变反应堆的均匀颗粒的方法和装置，其包括选择已经精确地分类为几微米尺寸的玻璃料的量，并且包含诸如尿素的封闭材料，所述封闭材料在加热时气化和膨胀 。 将大小的颗粒引入到包括温度在800℃至1300℃的加热垂直管的设备中。在通过管子的液滴期间将颗粒加热至熔融状态，其中封闭的材料气化以形成中空微球体，其稳定 在管的底部形成并插入收集液体。 该设备包括垂直耐热管，用于管的各个区域的加热器和用于引入玻璃料并收集形成的微球的装置。

公开(公告)号：US4880140A

公开(公告)日：1989-11-14

申请号：US186507

申请日：1988-04-26

Applicant: David E. Solomon ,  William J. Hillegas

Inventor： David E. Solomon ,  William J. Hillegas

IPC: B65D47/04

CPC classification number: B65D47/04

Abstract: A filter-separator pour-out cap for attachment to the neck opening of a container to separate particulate material from a liquidic suspension in the container when the container is tipped to pour out its contents. The cap comprises a filter-separator section having an upstream face at which flow from the container enters and a downstream face at which flow exits. This section comprises successive elements that are spaced axially apart from each other and are constructed and arranged to present at the upstream face juxtaposed uniformally spaced apart edges that define the entrances of openings that pass through the filter-separator from the upstream face to the downstream face. These elements have, in transverse cross section, a taper which narrows in the direction from the upstream face to the downstream face so that the openings are of progressively increasing taper in the same direction. In one embodiment of the invention these elements are identical circular rings. In another, the elements are convolutions of a helix. Various embodiments of caps are disclosed.

Abstract translation: 过滤器分离器倾倒盖，用于连接到容器的颈部开口，以在容器倾倒以将其内容物倾倒时将颗粒材料与容器中的液体悬浮液分离。 盖子包括一个过滤分离器部分，该部分具有一个从容器进入的上游面和流出的下游面。 该部分包括彼此轴向间隔开的连续元件，并且构造和布置成呈现在上游侧并置有均匀间隔开的边缘，该边缘限定了通过过滤器分离器从上游面到下游面的开口入口 。 这些元件在横截面中具有在从上游面到下游面的方向上变窄的锥形，使得开口在相同方向上逐渐增加锥度。 在本发明的一个实施例中，这些元件是相同的圆形环。 在另一个中，元素是螺旋的卷积。 公开了盖的各种实施例。

公开(公告)号：US4323420A

公开(公告)日：1982-04-06

申请号：US925437

申请日：1978-07-17

Applicant: Nino A. Masnari ,  Walter B. Rensel ,  Merrill G. Robinson ,  David E. Solomon ,  Kensall D. Wise ,  Gilbert H. Wuttke

Inventor： Nino A. Masnari ,  Walter B. Rensel ,  Merrill G. Robinson ,  David E. Solomon ,  Kensall D. Wise ,  Gilbert H. Wuttke

IPC: G21K5/08 ,  G21B1/15 ,  H05H1/22 ,  G21B1/00

CPC classification number: G21B1/19 ,  Y02E30/16 ,  Y10S376/916 ,  Y10T29/302

Abstract: An ICF target comprising a spherical pellet of fusion fuel surrounded by a concentric shell; and a process for manufacturing the same which includes the steps of forming hemispheric shells of a silicon or other substrate material, adhering the shell segments to each other with a fuel pellet contained concentrically therein, then separating the individual targets from the parent substrate. Formation of hemispheric cavities by deposition or coating of a mold substrate is also described. Coatings or membranes may also be applied to the interior of the hemispheric segments prior to joining.

Abstract translation: 一种ICF靶，包括由同心壳包围的熔融燃料的球形颗粒; 以及其制造方法，其包括以下步骤：形成硅或其它基底材料的半球壳，将壳段彼此以同心地包含在其中的燃料块彼此粘合，然后将各个靶与母基片分离。 还描述了通过沉积或涂覆模制基底形成半球体腔。 在接合之前，也可以将涂层或膜施加到半球段的内部。

公开(公告)号：US4022348A

公开(公告)日：1977-05-10

申请号：US541446

申请日：1975-01-16

Applicant: David E. Solomon

Inventor： David E. Solomon

IPC: G21F5/002 ,  B67B7/24

CPC classification number: G21F5/002

Abstract: A container for the storage, shipping and dispensing of pellets filled with gases such as hydrogen, deuterium, tritium, or mixtures of the same which has compactness, which is safe against fracture or accident, and which is reusable. The container consists of an outer housing with suitable inlet and outlet openings and electrical feed elements, the housing containing an activated sorber material in the form, for example, of titanium sponge or an activated zirconium aluminate cartridge. The gas to be stored is introduced into the chamber in the form of small spheres of material such as glass, plastic or plastic-carbon, or other materials which typically contain hydrogen isotopes. A specified quantity of filled pellets are introduced into the chamber after which it is evacuated and the sorber baked out by heating. Thus, any breakage in transit of the pellets will permit the gas to be sorbed and prevent release until the cartridge is again reheated.

Abstract translation: 用于储存，运输和分配填充有诸如氢气，氘，氚气体或其混合物的颗粒的颗粒，其具有紧凑性，对于断裂或事故是安全的并且是可重复使用的容器。 容器由具有合适的入口和出口开口的外壳以及供电元件组成，该外壳包含例如钛海绵或活化的铝酸铝盒形式的活化的吸附剂材料。 待储存的气体以诸如玻璃，塑料或塑料碳的材料的小球体或通常含有氢同位素的其它材料的形式引入室中。 将指定数量的填充颗粒引入室中，之后将其抽真空，并通过加热将吸附剂烘干。 因此，颗粒运输中的任何破损将允许气体被吸收并且防止释放，直到盒再次被再加热。