利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

25 条记录 (耗时 0.036 秒)

    Compounds which have activity at M1 receptor and their uses in medicine
    8.
    发明授权
    Compounds which have activity at M1 receptor and their uses in medicine 失效
    具有M1受体活性的化合物及其在药物中的用途

    公开(公告)号：US08481566B2

    公开(公告)日：2013-07-09

    申请号：US11852455

    申请日：2007-09-10

    申请人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Graham Walker

    发明人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Graham Walker

    IPC分类号： A61K31/445 ,  C07D401/04

    CPC分类号： C07D405/12 ,  C07D235/26

    摘要： Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

    摘要翻译： 提供式（I）化合物和盐和溶剂合物：其中R4是氟，R5选自氢，卤素，氰基，C1-6烷基，被一个或多个氟原子取代的C1-6烷基，C1-6烷氧基和C1- 6个被一个或多个氟原子取代的烷氧基; 并且R 6选自卤素，氰基，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基和被一个或多个氟原子取代的C 1-6烷氧基 更多的氟原子，Q是氢或C 1-6烷基。 预期化合物可用于治疗，例如治疗精神病和认知障碍。

    Compounds which have activity at M1 receptor and their uses in medicine
    9.
    发明授权
    Compounds which have activity at M1 receptor and their uses in medicine 有权
    具有M1受体活性的化合物及其在药物中的用途

    公开(公告)号：US08283364B2

    公开(公告)日：2012-10-09

    申请号：US12088465

    申请日：2006-09-27

    申请人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Paul William Smith ,  Graham Walker

    发明人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Paul William Smith ,  Graham Walker

    IPC分类号： A61K31/454 ,  C07D405/04

    CPC分类号： C07D405/12 ,  C07D235/26

    摘要： Compounds of formula (I) and salts are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

    摘要翻译： 提供式（I）和盐的化合物：其中R 4是氟，R 5选自氢，卤素，氰基，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基和C 1-6烷氧基取代 具有一个或多个氟原子; 并且R 6选自卤素，氰基，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基和被一个或多个氟原子取代的C 1-6烷氧基 更多的氟原子，Q是氢或C 1-6烷基。 预期化合物可用于治疗，例如治疗精神病和认知障碍。

    Compounds which have activity at M1 receptor and their uses in medicine
    10.
    发明授权
    Compounds which have activity at M1 receptor and their uses in medicine 失效
    具有M1受体活性的化合物及其在药物中的用途

    公开(公告)号：US08288412B2

    公开(公告)日：2012-10-16

    申请号：US12088451

    申请日：2006-09-27

    申请人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Paul William Smith ,  Graham Walker

    发明人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Paul William Smith ,  Graham Walker

    IPC分类号： A61K31/454 ,  C07D405/04

    CPC分类号： C07D401/14

    摘要： Compounds of formula (I) and salts are provided: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

    摘要翻译： 提供式（I）和盐的化合物：其中R 5选自卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基，被一个或多个氟原子取代的C 1-6烷氧基， 和氰基; R 6选自卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基，被一个或多个 氟原子和氰基; Q是氢或C 1-6烷基。 化合物是M1激动剂，可用于治疗，例如治疗精神病和认知障碍。