公开(公告)号：US06872536B1

公开(公告)日：2005-03-29

申请号：US09437701

申请日：1999-11-10

申请人： David Roe ,  Christine Maria Ribic ,  Betty Chee-Ion Lawrence ,  Catherine Michelle Pollock ,  Alfred Pollack

发明人： David Roe ,  Christine Maria Ribic ,  Betty Chee-Ion Lawrence ,  Catherine Michelle Pollock ,  Alfred Pollack

IPC分类号： A61K51/08 ,  C07K7/02 ,  C07K7/06 ,  A61K38/04 ,  G01N33/53

CPC分类号： C07K7/06 ,  A61K51/08 ,  A61K51/088 ,  C07K7/02

摘要： Radiopharmaceuticals comprising molecules that target to N-formyl-methionyl-leucy-phenylalanine (fMLF) receptor on leukocytes in order to target sites of inflammation for diagnostic imaging are described. The targeting molecules are attached to capping groups that make the entire molecule either antagonists or weak agonists of fMLF receptor and therefore do not elicit a chemotactic response resulting in neutropenia. The preferred targeting molecule is ReO-Gly-lys(Dimethylgly-t-Butylgly-cys-gly)glu-trp-phe-leu-nle-NHCOcyclopropyl (wherein the peptide sequence NLeu-Leu-Phe-Trp-Glu-Lys-Gly is SEQ. ID No. 1.) The invention also relates to the use of combinatorial chemistry to obtain preferred molecules that target sites of inflammation for diagnostic imaging.

摘要翻译： 描述了包含靶向白细胞上的N-甲酰基 - 甲硫氨酰 - 亮氨酸 - 苯丙氨酸（fMLF）受体的分子，以靶向用于诊断成像的炎症部位的放射性药物。 靶向分子连接到使整个分子成为fMLF受体的拮抗剂或弱激动剂的封端基团，因此不引起导致中性粒细胞减少的趋化性反应。 优选的靶向分子是ReO-Gly-lys（Dimethylgly-t-Butylgly-cys-gly）glu-trp-phe-leu-nle-NHCO环丙基（其中肽序列NLeu-Leu-Phe-Trp-Glu-Lys-Gly 是SEQ ID NO No.1）。本发明还涉及组合化学的用途来获得靶向诊断成像炎症部位的优选分子。

公开(公告)号：US20050100507A1

公开(公告)日：2005-05-12

申请号：US11014403

申请日：2004-12-16

申请人： David Roe ,  Christine Ribic ,  Betty Lawrence ,  Catherine Pollock ,  Alfred Pollack

发明人： David Roe ,  Christine Ribic ,  Betty Lawrence ,  Catherine Pollock ,  Alfred Pollack

IPC分类号： A61K51/08 ,  C07K7/02 ,  C07K7/06 ,  A61K51/00 ,  G01N33/53 ,  G01N33/543

CPC分类号： C07K7/06 ,  A61K51/08 ,  A61K51/088 ,  C07K7/02

摘要： Radiopharmaceuticals comprising molecules that target to N-formyl-methionyl-leucyl-phenylalanine (fMLF) receptor on leukocytes in order to target sites of inflammation for diagnostic imaging are described. The targeting molecules are attached to capping groups that make the entire molecule either antagonists or weak agonists of fMLF receptor and therefore do not elicit a chemotactic response resulting in neutropenia. The preferred targeting molecule is ReO-Gly-lys(Dimethylgly-t-Butylgly-cys-gly)-glu-trp-phe-leu-nle-NHCOcyclopropyl. The invention also relates to the use of combinatorial chemistry to obtain preferred molecules that target sites of inflammation for diagnostic imaging.

摘要翻译： 描述了包含靶向白细胞上的N-甲酰基 - 甲硫氨酰 - 亮氨酰 - 苯丙氨酸（fMLF）受体以靶向用于诊断成像的炎症部位的分子的放射性药物。 靶向分子连接到使整个分子成为fMLF受体的拮抗剂或弱激动剂的封端基团，因此不引起导致中性粒细胞减少的趋化性反应。 优选的靶向分子是ReO-Gly-lys（Dimethylgly-t-Butylgly-cys-gly）-glu-trp-phe-leu-nle-NHCO环丙基。 本发明还涉及组合化学的用途以获得靶向诊断成像炎症部位的优选分子。

公开(公告)号：US4680566A

公开(公告)日：1987-07-14

申请号：US765967

申请日：1985-08-15

申请人： Walter Goseberg ,  Alfred Pollack

发明人： Walter Goseberg ,  Alfred Pollack

IPC分类号： H01F21/06 ,  H01F27/28 ,  H01F27/34

CPC分类号： H01F21/06

摘要： The invention concerns a coil arrangement with three windings arranged coaxially, where the outer coils are connected in series. The inductances of the outer coils are of equal magnitude and their magnetic fields have opposing polarities.The center winding induces in the series circuit of the outer windings currents which cancel each other out. The outer windings with their stray inductances form a coil which is separated from the center one and can be applied for other purposes.

摘要翻译： 本发明涉及具有同轴布置的三个绕组的线圈装置，其中外部线圈串联连接。 外部线圈的电感值相等，它们的磁场具有相反的极性。 中心绕组在外绕组的串联电路中感应出彼此抵消的电流。 具有杂散电感的外绕组形成与中心绕组分离的线圈，可用于其他目的。

公开(公告)号：US5574140A

公开(公告)日：1996-11-12

申请号：US274850

申请日：1994-07-14

申请人： Alfred Pollack ,  Robert A. Kirby ,  Robert Dufault

发明人： Alfred Pollack ,  Robert A. Kirby ,  Robert Dufault

IPC分类号： G21G4/08 ,  A61K51/08 ,  C07C323/60 ,  C07C327/32 ,  G01N33/534 ,  G01N33/60 ,  C07F13/00 ,  C07C281/00

CPC分类号： G01N33/60 ,  A61K51/0478 ,  A61K51/088 ,  C07C323/60 ,  C07C327/32 ,  G01N33/534 ,  Y02P20/55

摘要： Radionuclide chelating compounds are provided for conjugation to targetting molecules such as proteins, peptides or antibodies. The resulting labelled targetting molecules may be used in diagnosis and therapy. ##STR1##

摘要翻译： 提供放射性核素螯合化合物用于与靶向分子例如蛋白质，肽或抗体结合。 所得标记的靶向分子可用于诊断和治疗。

公开(公告)号：US4806831A

公开(公告)日：1989-02-21

申请号：US62186

申请日：1987-06-15

申请人： Walter Goseberg ,  Alfred Pollack

发明人： Walter Goseberg ,  Alfred Pollack

IPC分类号： H01F21/06 ,  H01J29/70 ,  H01F27/28 ,  H01J29/76

CPC分类号： H01F21/06

摘要： A coil arrangement with three windings arranged coaxially, where the outer coils are connected in series. The inductances of the outer coils are of equal magnitude and their magnetic fields have opposing polarities.The center winding induces currents in the series circuit of the outer windings which cancel each other out. The outer windings with their stray inductances form a coil which is separated from the center one and can be applied for other purposes.

摘要翻译： 具有同轴布置的三个绕组的线圈装置，其中外部线圈串联连接。 外部线圈的电感值相等，它们的磁场具有相反的极性。 中心绕组引起外绕组串联电路中的电流，这些电流互相抵消。 具有杂散电感的外绕组形成与中心绕组分离的线圈，可用于其他目的。