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公开(公告)号:US20130101608A1
公开(公告)日:2013-04-25
申请号:US13704388
申请日:2011-06-15
申请人: David Satijn , Sandra Verploegen , Wim Bleeker , Steen Lisby , Jan Van De Winkel , Patrick Van Berkel , Paul Parren
发明人: David Satijn , Sandra Verploegen , Wim Bleeker , Steen Lisby , Jan Van De Winkel , Patrick Van Berkel , Paul Parren
CPC分类号: A61K47/48561 , A61K45/06 , A61K47/6817 , A61K47/6849 , C07K16/30 , C07K16/36 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.
摘要翻译: 针对组织因子的抗体药物偶联物。 还公开了包含抗体和抗体药物偶联物的药物组合物,以及使用抗体和抗体药物偶联物的治疗和诊断方法。
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公开(公告)号:US09168314B2
公开(公告)日:2015-10-27
申请号:US13704388
申请日:2011-06-15
申请人: David Satijn , Sandra Verploegen , Wim Bleeker , Steen Lisby , Jan Van De Winkel , Patrick Van Berkel , Paul Parren
发明人: David Satijn , Sandra Verploegen , Wim Bleeker , Steen Lisby , Jan Van De Winkel , Patrick Van Berkel , Paul Parren
IPC分类号: A61K39/395 , C07K16/00 , A61K47/48 , C07K16/36 , A61K45/06
CPC分类号: A61K47/48561 , A61K45/06 , A61K47/6817 , A61K47/6849 , C07K16/30 , C07K16/36 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.
摘要翻译: 针对组织因子的抗体药物偶联物。 还公开了包含抗体和抗体药物偶联物的药物组合物,以及使用抗体和抗体药物偶联物的治疗和诊断方法。
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公开(公告)号:US20140030273A1
公开(公告)日:2014-01-30
申请号:US13982959
申请日:2012-02-01
申请人: Sandra Verploegen , Marije Overdijk , Riemke Van Dijkhuizen , Willem Karel Bleeker , Patrick Van Berkel , Paul Parren , Steen Lisby
发明人: Sandra Verploegen , Marije Overdijk , Riemke Van Dijkhuizen , Willem Karel Bleeker , Patrick Van Berkel , Paul Parren , Steen Lisby
IPC分类号: C07K16/18 , A61K45/06 , A61K38/19 , A61K35/76 , A61K38/16 , A61K35/14 , A61K39/395 , A61K31/7088
CPC分类号: A61K39/39541 , A61K31/7088 , A61K35/17 , A61K35/76 , A61K38/162 , A61K38/19 , A61K39/39533 , A61K39/39566 , A61K45/06 , A61K47/6849 , A61K51/1027 , A61K2039/505 , A61K2121/00 , C07K16/18 , C07K16/2833 , C07K2317/21 , C07K2317/33 , C07K2317/73 , C07K2317/77 , C07K2317/92 , Y02A50/472
摘要: Isolated human monoclonal antibodies which bind to human CD74 and related antibody-drug conjugates are disclosed. Pharmaceutical compositions comprising the antibodies or antibody-drug conjugates, and therapeutic and diagnostic methods for using the antibodies and/or antibody-drug conjugates, are also disclosed.
摘要翻译: 公开了与人CD74和相关抗体 - 药物偶联物结合的分离的人单克隆抗体。 还公开了包含抗体或抗体 - 药物偶联物的药物组合物,以及使用抗体和/或抗体 - 药物偶联物的治疗和诊断方法。
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公开(公告)号:US09540433B2
公开(公告)日:2017-01-10
申请号:US13982959
申请日:2012-02-01
申请人: Sandra Verploegen , Marije Overdijk , Riemke Van Dijkhuizen , Willem Karel Bleeker , Patrick Van Berkel , Paul Parren , Steen Lisby
发明人: Sandra Verploegen , Marije Overdijk , Riemke Van Dijkhuizen , Willem Karel Bleeker , Patrick Van Berkel , Paul Parren , Steen Lisby
IPC分类号: A61K39/395 , C07K16/28 , C07K16/30 , C07K16/42 , C07K16/18 , A61K47/48 , A61K51/10 , A61K31/7088 , A61K35/17 , A61K35/76 , A61K38/16 , A61K38/19 , A61K45/06 , A61K39/00
CPC分类号: A61K39/39541 , A61K31/7088 , A61K35/17 , A61K35/76 , A61K38/162 , A61K38/19 , A61K39/39533 , A61K39/39566 , A61K45/06 , A61K47/6849 , A61K51/1027 , A61K2039/505 , A61K2121/00 , C07K16/18 , C07K16/2833 , C07K2317/21 , C07K2317/33 , C07K2317/73 , C07K2317/77 , C07K2317/92 , Y02A50/472
摘要: Isolated human monoclonal antibodies which bind to human CD74 and related antibody-drug conjugates are disclosed. Pharmaceutical compositions comprising the antibodies or antibody-drug conjugates, and therapeutic and diagnostic methods for using the antibodies and/or antibody-drug conjugates, are also disclosed.
摘要翻译: 公开了与人CD74和相关抗体 - 药物偶联物结合的分离的人单克隆抗体。 还公开了包含抗体或抗体 - 药物偶联物的药物组合物,以及使用抗体和/或抗体 - 药物偶联物的治疗和诊断方法。
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公开(公告)号:US09040050B2
公开(公告)日:2015-05-26
申请号:US12442808
申请日:2007-09-26
申请人: Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
发明人: Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
IPC分类号: A61K39/395 , C07K16/28 , A61K45/06 , A61K39/00
CPC分类号: C07K16/2896 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/34 , A61K2300/00
摘要: The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non-corticosteroid chemotherapeutic agent.
摘要翻译: 本发明涉及使用包含结合CD38的抗体,皮质类固醇和非皮质类固醇化学治疗剂的组合疗法治疗癌症的新方法。
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公开(公告)号:US20100092489A1
公开(公告)日:2010-04-15
申请号:US12442808
申请日:2007-09-26
申请人: Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
发明人: Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
IPC分类号: A61K39/395 , A61P35/00
CPC分类号: C07K16/2896 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/34 , A61K2300/00
摘要: The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non- corticosteroid chemotherapeutic agent.
摘要翻译: 本发明涉及使用包含结合CD38的抗体,皮质类固醇和非皮质类固醇化学治疗剂的组合疗法治疗癌症的新方法。
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公开(公告)号:US20130004480A1
公开(公告)日:2013-01-03
申请号:US12308836
申请日:2007-07-04
申请人: Paul Parren , Steen Lisby , Ole Baadsgaard
发明人: Paul Parren , Steen Lisby , Ole Baadsgaard
IPC分类号: A61K39/395 , A61P11/00
CPC分类号: C07K16/2887 , A61K2039/505 , C07K2317/21
摘要: Use of CD20 binding molecules, such as anti-CD20 antibodies, for the treatment of chronic obstructive pulmonary disease (COPD).
摘要翻译: 使用CD20结合分子,如抗CD20抗体,用于治疗慢性阻塞性肺疾病(COPD)。
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公开(公告)号:US09428582B2
公开(公告)日:2016-08-30
申请号:US12306436
申请日:2007-07-03
申请人: Klaus Edvardsen , Steen Lisby , Ole Baadsgaard
发明人: Klaus Edvardsen , Steen Lisby , Ole Baadsgaard
IPC分类号: A61K31/495 , A61K39/395 , C07K16/28 , A61K45/06 , C07K16/24 , A61K39/00
CPC分类号: C07K16/2863 , A61K39/3955 , A61K45/06 , A61K2039/507 , C07K16/244 , A61K2300/00
摘要: The invention relates to a method for the treatment of a disease susceptible to anti-EGFR treatment, comprising the step of administering, to a human being in nee thereof, a combination of an anti-EGFR agent and an anti-neutrophil-chemoattracta agent, wherein said anti-neutrophil-chemoattractant agent is administered in a dosage regimen that is sufficient to reduce one or more undesired dermatological side-effects the anti-EGFR agent. In one embodiment, the anti-EGFR agent is an anti-EGF antibody and the anti-neutrophil-chemoattractant agent is an anti-IL-8 antibody.
摘要翻译: 本发明涉及一种治疗易受抗EGFR治疗的疾病的方法,包括向其中的人施用抗EGFR药物和抗中性粒细胞 - 化学吸收剂的组合的步骤, 其中所述抗嗜中性粒细胞趋化剂以足以减少抗EGFR药物的一种或多种非期望的皮肤病学副作用的剂量方案给药。 在一个实施方案中,抗EGFR剂为抗EGF抗体,抗中性粒细胞趋化剂为抗IL-8抗体。
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公开(公告)号:US20100150936A1
公开(公告)日:2010-06-17
申请号:US12306436
申请日:2007-07-03
申请人: Klaus Edvardsen , Steen Lisby , Ole Baadsgaard
发明人: Klaus Edvardsen , Steen Lisby , Ole Baadsgaard
IPC分类号: A61K39/395 , A61P37/06
CPC分类号: C07K16/2863 , A61K39/3955 , A61K45/06 , A61K2039/507 , C07K16/244 , A61K2300/00
摘要: The invention relates to a method for the treatment of a disease susceptible to anti-EGFR treatment, comprising the step of administering, to a human being in nee thereof, a combination of an anti-EGFR agent and an anti-neutrophil-chemoattracta agent, wherein said anti-neutrophil-chemoattractant agent is administered in a dosage regimen that is sufficient to reduce one or more undesired dermatological side-effects the anti-EGFR agent. In one embodiment, the anti-EGFR agent is an anti-EGF antibody and the anti-neutrophil-chemoattractant agent is an anti-IL-8 antibody.
摘要翻译: 本发明涉及一种治疗易受抗EGFR治疗的疾病的方法,包括向其中的人施用抗EGFR药物和抗中性粒细胞 - 化学吸收剂的组合的步骤, 其中所述抗嗜中性粒细胞趋化剂以足以减少抗EGFR药物的一种或多种非期望的皮肤病学副作用的剂量方案给药。 在一个实施方案中,抗EGFR剂为抗EGF抗体,抗中性粒细胞趋化剂为抗IL-8抗体。
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