公开(公告)号：US09180101B2

公开(公告)日：2015-11-10

申请号：US13108050

申请日：2011-05-16

申请人： Dong-Joon Oh ,  Byoung-Ki Kim ,  Byung-Kwan Moon ,  Ji-Seok Yoo ,  Dae-Hee Shin ,  Byung-Hwan Ryoo

发明人： Dong-Joon Oh ,  Byoung-Ki Kim ,  Byung-Kwan Moon ,  Ji-Seok Yoo ,  Dae-Hee Shin ,  Byung-Hwan Ryoo

IPC分类号： A61K9/22 ,  A61K38/00 ,  A61K9/50

CPC分类号： A61K9/5084

摘要： Disclosed is a pharmaceutical composition simultaneously having a rapid acting property and a long-acting property, comprising a sustained-release part coated with a water-insoluble polymer on the surface, comprising a first active pharmaceutical ingredient, at least one release control base selected from the group consisting of water-insoluble polymer, and water-soluble viscous polymer, and a pharmaceutically acceptable carrier; and, an immediate release part comprising a second active pharmaceutical ingredient and a pharmaceutically acceptable carrier. The pharmaceutical composition exhibits independent release properties of the immediate release part and the sustained-release part by coating the surface of the sustained-release part comprising an active pharmaceutical ingredient, a release control base and a pharmaceutically acceptable carrier with a water-insoluble polymer to separate it from the immediate release part, and it may be prepared by a relatively simple process without specification limitation to the contents and the kinds of usable pharmaceutically active ingredients.

摘要翻译： 公开了同时具有快速作用性能和长效性的药物组合物，其包含在表面上涂覆有不溶于水的聚合物的缓释部分，其包含第一活性药物成分，至少一种选自 由水不溶性聚合物和水溶性粘性聚合物组成的组和药学上可接受的载体; 以及包含第二活性药物成分和药学上可接受的载体的速释部分。 药物组合物通过将包含活性药物成分，释放对照碱和药学上可接受的载体的缓释部分的表面用水不溶性聚合物涂覆到快速释放部分和缓释部分上来显示出独立的释放性能， 将其与立即释放部分分离，并且可以通过相对简单的方法制备而不限制含量和可用的药物活性成分的种类。

公开(公告)号：US20110217374A1

公开(公告)日：2011-09-08

申请号：US13108050

申请日：2011-05-16

申请人： Dong-Joon OH ,  Byoung-Ki Kim ,  Byung-Kwan Moon ,  Ji-Seok Yoo ,  Dae-Hee Shin ,  Byung-Hwan Ryoo

发明人： Dong-Joon OH ,  Byoung-Ki Kim ,  Byung-Kwan Moon ,  Ji-Seok Yoo ,  Dae-Hee Shin ,  Byung-Hwan Ryoo

IPC分类号： A61K9/22 ,  A61K31/167 ,  A61K31/522 ,  A61K31/4545 ,  A61K31/4453 ,  A61K31/135 ,  A61K31/455 ,  A61K31/47 ,  A61K31/505 ,  A61K31/40 ,  A61K31/4704 ,  A61K31/64 ,  A61K31/155 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/685 ,  A61K9/00

CPC分类号： A61K9/5084

摘要： Disclosed is a pharmaceutical composition simultaneously having a rapid acting property and a long-acting property, comprising a sustained-release part coated with a water-insoluble polymer on the surface, comprising a first active pharmaceutical ingredient, at least one release control base selected from the group consisting of water-insoluble polymer, and water-soluble viscous polymer, and a pharmaceutically acceptable carrier; and, an immediate release part comprising a second active pharmaceutical ingredient and a pharmaceutically acceptable carrier. The pharmaceutical composition exhibits independent release properties of the immediate release part and the sustained-release part by coating the surface of the sustained-release part comprising an active pharmaceutical ingredient, a release control base and a pharmaceutically acceptable carrier with a water-insoluble polymer to separate it from the immediate release part, and it may be prepared by a relatively simple process without specification limitation to the contents and the kinds of usable pharmaceutically active ingredients.

摘要翻译： 公开了同时具有快速作用性能和长效性的药物组合物，其包含在表面上涂覆有不溶于水的聚合物的缓释部分，其包含第一活性药物成分，至少一种选自 由水不溶性聚合物和水溶性粘性聚合物组成的组和药学上可接受的载体; 以及包含第二活性药物成分和药学上可接受的载体的速释部分。 药物组合物通过将包含活性药物成分，释放对照碱和药学上可接受的载体的缓释部分的表面用水不溶性聚合物涂覆到快速释放部分和缓释部分上来显示出独立的释放性能， 将其与立即释放部分分离，并且可以通过相对简单的方法制备而不限制含量和可用的药物活性成分的种类。