公开(公告)号：US09493415B2

公开(公告)日：2016-11-15

申请号：US14539696

申请日：2014-11-12

Applicant: Dow AgroSciences LLC ,  University of Michigan

Inventor： Laura Allen ,  Melanie Sanford ,  Shin Hee Lee ,  Douglas Bland ,  Yang Cheng ,  Gary Roth ,  Joseck M. Muhuhi

IPC: C07D213/803

CPC classification number: C07D213/803

Abstract: Methods of preparing a fluorinated substrate by combining potassium fluoride, a quaternary ammonium salt, and a substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide the fluorinated substrate are disclosed.

Abstract translation: 公开了通过组合氟化钾，季铵盐和被至少一个氯，溴，磺酰基​​或硝基取代的基底来制备氟化底物从而提供氟化基底的方法。

公开(公告)号：US09878983B2

公开(公告)日：2018-01-30

申请号：US15228188

申请日：2016-08-04

Applicant: Dow AgroSciences LLC ,  The Regents of the University of Michigan

Inventor： Melanie Sanford ,  Sarah Ryan ,  Sydonie Schimler ,  Yang Cheng ,  Douglas Bland

IPC: C07D213/79 ,  C07D213/26 ,  C07D213/76 ,  C07D213/84 ,  C07D213/85 ,  C07D215/04 ,  C07D217/02 ,  C07D237/08 ,  C07D213/803

CPC classification number: C07D213/79 ,  C07D213/26 ,  C07D213/76 ,  C07D213/803 ,  C07D213/84 ,  C07D213/85 ,  C07D215/04 ,  C07D217/02 ,  C07D237/08

Abstract: Disclosed are mild temperature (e.g., from 0 to 80° C.) SNAr fluorinations of a variety of halide and sulfonate substituted aryl and heteroaryl substrates using NMe4F.

公开(公告)号：US20140206881A1

公开(公告)日：2014-07-24

申请号：US14222912

申请日：2014-03-24

Applicant: Dow AgroSciences LLC

Inventor： Yuanming Zhu ,  Gregory T. Whiteker ,  James M. Renga ,  Kim E. Arndt ,  Gary Roth ,  David E. Podhorez ,  Scott P. West ,  Yang Cheng

IPC: C07D213/803

CPC classification number: C07D213/81 ,  C07D213/78 ,  C07D213/79 ,  C07D213/803

Abstract: 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation, nitrile hydrolysis, esterification, and transition metal assisted coupling.

Abstract translation: 通过一系列涉及氟交换，胺化，卤素交换，卤化，腈水解，酯化等步骤的方法，可以方便地从4,5,6-三氯吡啶腈制备4-氨基-5-氟-3-卤代-6-（取代的） 和过渡金属辅助耦合。

公开(公告)号：US20140031556A1

公开(公告)日：2014-01-30

申请号：US13949060

申请日：2013-07-23

Applicant: Dow AgroSciences LLC

Inventor： James M. Renga ,  Yang Cheng ,  Joseck M. Muhuhi ,  David E. Podhorez ,  Gary A. Roth ,  Scott P. West ,  Gregory T. Whiteker ,  Yuanming Zhu

IPC: C07D213/803

CPC classification number: C07D213/803

Abstract: Provided herein are processes for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates comprising a step of converting chloropicolinoyl chlorides to fluoropicolinoyl fluorides.

Abstract translation: 本文提供了制备4-氨基-5-氟-3-卤代-6-（取代的）吡啶甲酸盐的方法，其包括将氯吡酰甲酰氯转化为氟吡啶酰基氟化物的步骤。

公开(公告)号：US20170066721A1

公开(公告)日：2017-03-09

申请号：US15228188

申请日：2016-08-04

Applicant: Dow AgroSciences LLC ,  The Regents of the University of Michigan

Inventor： Melanie Sanford ,  Sarah Ryan ,  Sydonie Schimler ,  Yang Cheng ,  Douglas Bland

IPC: C07D213/79 ,  C07D215/04 ,  C07D213/76 ,  C07D237/08 ,  C07D213/84 ,  C07D213/85 ,  C07D213/803 ,  C07D217/02

CPC classification number: C07D213/79 ,  C07D213/26 ,  C07D213/76 ,  C07D213/803 ,  C07D213/84 ,  C07D213/85 ,  C07D215/04 ,  C07D217/02 ,  C07D237/08

Abstract: Disclosed are mild temperature (e.g., from 0 to 80° C.) SNAr fluorinations of a variety of halide and sulfonate substituted aryl and heteroaryl substrates using NMe4F.

Abstract translation: 公开了温和的温度（例如，0至80℃）。使用NMe4F对各种卤化物和磺酸酯取代的芳基和杂芳基底物进行SNAr氟化。

公开(公告)号：US09376388B2

公开(公告)日：2016-06-28

申请号：US14667109

申请日：2015-03-24

Applicant: Dow AgroSciences LLC

Inventor： James M. Renga ,  Yang Cheng ,  Joseck M. Muhuhi ,  David E. Podhorez ,  Gary A. Roth ,  Scott P. West ,  Gregory T. Whiteker ,  Yuanming Zhu

IPC: C07D213/78 ,  C07D213/803 ,  C07D213/55 ,  C07D213/807

CPC classification number: C07D213/55 ,  C07D213/78 ,  C07D213/803 ,  C07D213/807

Abstract: Provided herein are fluoropicolinoyl fluorides and processes for their preparation. In some embodiments, provided herein is a process for the preparation of 5-fluoro-6-aryl-picolinoyl fluorides from chloropicolinoyl chlorides.

公开(公告)号：US08871943B2

公开(公告)日：2014-10-28

申请号：US13949060

申请日：2013-07-23

Applicant: Dow AgroSciences LLC

Inventor： James M. Renga ,  Yang Cheng ,  Joseck M. Muhuhi ,  David E. Podhorez ,  Gary A. Roth ,  Scott P. West ,  Gregory T. Whiteker ,  Yuanming Zhu

IPC: C07D213/803

CPC classification number: C07D213/803

Abstract: Provided herein are processes for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates comprising a step of converting chloropicolinoyl chlorides to fluoropicolinoyl fluorides.

Abstract translation: 本文提供了制备4-氨基-5-氟-3-卤代-6-（取代的）吡啶甲酸盐的方法，其包括将氯吡酰甲酰氯转化为氟吡啶酰基氟化物的步骤。

公开(公告)号：US09045427B2

公开(公告)日：2015-06-02

申请号：US13949053

申请日：2013-07-23

Applicant: Dow AgroSciences LLC

Inventor： James M. Renga ,  Yang Cheng ,  Joseck M. Muhuhi ,  David E. Podhorez ,  Gary A. Roth ,  Scott P. West ,  Gregory T. Whiteker ,  Yuanming Zhu

IPC: C07D213/78 ,  C07D213/803 ,  C07D213/807

CPC classification number: C07D213/55 ,  C07D213/78 ,  C07D213/803 ,  C07D213/807

Abstract: Provided herein are fluoropicolinoyl fluorides and processes for their preparation. In some embodiments, provided herein is a process for the preparation of 5-fluoro-6-aryl-picolinoyl fluorides from chloropicolinoyl chlorides.

Abstract translation: 本文提供氟吡唑啉基氟化物及其制备方法。 在一些实施方案中，本文提供了一种从氯吡啶酰氯制备5-氟-6-芳基 - 吡啶甲酰基氟化物的方法。

公开(公告)号：US20150141654A1

公开(公告)日：2015-05-21

申请号：US14539696

申请日：2014-11-12

Applicant: Dow AgroSciences LLC ,  University of Michigan

Inventor： Laura Allen ,  Melanie Sanford ,  Shin Hee Lee ,  Douglas Bland ,  Yang Cheng ,  Gary Roth ,  Joseck M. Muhuhi

IPC: C07D213/803

CPC classification number: C07D213/803

Abstract: Methods of preparing a fluorinated substrate by combining potassium fluoride, a quaternary ammonium salt, and a substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide the fluorinated substrate are disclosed.

Abstract translation: 公开了通过组合氟化钾，季铵盐和被至少一个氯，溴，磺酰基​​或硝基取代的基底来制备氟化底物从而提供氟化基底的方法。

公开(公告)号：US20180050980A1

公开(公告)日：2018-02-22

申请号：US15673645

申请日：2017-08-10

Applicant: Dow AgroSciences LLC

Inventor： Douglas C. Bland ,  Yang Cheng

IPC: C07C209/68 ,  C07C211/63

CPC classification number: C07C209/68 ,  C07C211/63 ,  C08K5/17

Abstract: A method for the preparation of anhydrous, alcohol-free tetramethylammonium fluoride is described. The method includes fluorination of tetramethylammonium chloride with potassium fluoride in an alcohol solvent, removal of insoluble potassium salts, and finally, removal of the alcohol solvent and replacement of it with an aprotic solvent.