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    Novel polymers for delivering nitric oxide in vivo
    2.
    发明申请
    Novel polymers for delivering nitric oxide in vivo 失效
    用于在体内递送一氧化氮的新型聚合物

    公开(公告)号：US20030078365A1

    公开(公告)日：2003-04-24

    申请号：US10164366

    申请日：2002-06-05

    Applicant: Duke University

    Inventor： Jonathan S. Stamler ,  Eric J. Toone ,  Richard S. Stack

    IPC: C08G075/00

    CPC classification number: A61K31/785 ,  A61K47/61 ,  A61K47/6951 ,  A61L29/10 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/114 ,  A61L2300/416 ,  A61L2300/42 ,  B82Y5/00 ,  C08B37/0012 ,  C08G75/00 ,  C08L5/16 ,  C09D105/16 ,  G06F19/00 ,  Y10T428/1393

    Abstract: Disclosed are novel polymers derivatized with at least one nullSNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized nullS-nitrosyl groups. In another embodiment the S-nitrosylated polymer prepared by polymerizing a compound represented by the following structural formula: 1 R is an organic radical. Each Xnull is an independently chosen aliphatic group or substituted aliphatic group. Preferably, each Xnull is the same and is a C2-C6 alkylene group, more preferably nullCH2null, nullCH2CH2null, nullCH2CH2CH2null or nullCH2CH2CH2CH2null. p and m are independently a positive integer such that pnullm is greater than two. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.

    Abstract translation: 公开了每聚合物的每1200原子质量单位衍生自至少一个-SNO基团的新型聚合物。 在一个实施方案中，S-亚硝基化聚合物具有稳定的-S-亚硝酰基。 在另一个实施方案中，通过聚合由以下结构式表示的化合物制备的S-亚硝基化聚合物：R是有机基团。 每个X'是独立选择的脂族基团或取代的脂族基团。 优选地，每个X'相同且为C2-C6亚烷基，更优选为-CH2-，-CH2CH2-，-CH2CH2CH2-或-CH2CH2CH2CH2-。 p和m独立地为正整数，使得p + m大于2。 本发明的聚合物可用于涂覆医疗装置以将体内的一氧化氮输送到治疗部位。

    Stable no-delivering compounds
    4.
    发明申请
    Stable no-delivering compounds 有权
    稳定的不输送化合物

    公开(公告)号：US20040019105A1

    公开(公告)日：2004-01-29

    申请号：US10387116

    申请日：2003-03-11

    Applicant: Duke University

    Inventor： Eric J. Toone ,  Jonathan S. Stamler

    IPC: A61K031/21 ,  C07C381/00

    CPC classification number: A61L2/23 ,  A61L2/20 ,  A61L29/16 ,  A61L2300/114 ,  A61L2300/216 ,  C07C381/00

    Abstract: Disclosed are novel NO-releasing compounds which comprise a stabilized S-nitrosyl group and a free alcohol or a free thiol group. Also disclosed is a method of preparing the NO-releasing compounds. The method comprises reacting a polythiol or a thioalcohol with a nitrosylating agent. Also disclosed are medical devices coated with the disclosed compounds, methods of delivering NO to treatments sites in a subject by utilizing the medical devices and methods of sterilizing surfaces.

    Abstract translation: 公开了包含稳定的S-亚硝酰基和游离醇或游离巯基的新型NO释放化合物。 还公开了制备释放NO的化合物的方法。 该方法包括使多硫醇或硫代醇与亚硝酰化剂反应。 还公开了涂覆有所公开的化合物的医疗装置，通过利用医疗装置和灭菌表面的方法将NO递送到受试者的治疗部位的方法。

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