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公开(公告)号：US10723990B2
公开(公告)日：2020-07-28
申请号：US14782487
申请日：2014-03-17
Applicant: EMD Millipore Corporation
Inventor： Kara Der , Anne Hansen , James McSweeney , David Kraus , Jeffrey Pearsons , Amy Wood
Abstract: A container, such as a disposable or single use bioreactor, optionally having one or more inlets and one or more outlets and a mixer associated with the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The container includes a flexible baffle shaped and positioned within the container to improve mixing, particularly to improve low shear mixing. The baffle is positioned within the container so as to disrupt the vortex formed by the mixer, or prevent formation of a vortex. The baffle is shaped with both horizontal and vertical elements to enhance disruption of the vortex across the entire vessel height and provide homogeneous mixing throughout all operating volumes. In certain embodiments, the baffle is X-shaped.
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公开(公告)号：US20160040113A1
公开(公告)日：2016-02-11
申请号：US14782487
申请日：2014-03-17
Applicant: EMD Millipore Corporation
Inventor： Kara Der , Anne Hansen , James McSweeney , David Kraus , Jeffrey Pearsons , Amy Wood
Abstract: A container, such as a disposable or single use bioreactor, optionally having one or more inlets and one or more outlets and a mixer associated with the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The container includes a flexible baffle shaped and positioned within the container to improve mixing, particularly to improve low shear mixing. The baffle is positioned within the container so as to disrupt the vortex formed by the mixer, or prevent formation of a vortex. The baffle is shaped with both horizontal and vertical elements to enhance disruption of the vortex across the entire vessel height and provide homogeneous mixing throughout all operating volumes. In certain embodiments, the baffle is X-shaped.
Abstract translation: 一个容器，例如一次性或单次使用的生物反应器，任选地具有一个或多个入口和一个或多个出口以及与该容器相关联的混合器，以使包含或添加到一个或多个成分中的一种或多种成分混合，分散，均化和/或循环 容器 容器包括形状并定位在容器内的柔性挡板以改善混合，特别是改善低剪切混合。 挡板位于容器内，以便破坏由混合器形成的涡流，或防止形成涡流。 挡板被成形为具有水平和垂直元件，以增强跨越整个容器高度的涡流的破坏，并在整个操作体积中提供均匀的混合。 在某些实施例中，挡板是X形的。
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公开(公告)号：US20210054327A1
公开(公告)日：2021-02-25
申请号：US16964646
申请日：2019-03-13
Applicant: EMD Millipore Corporation
Inventor： Jeffrey Pearsons , Amy Wood , David Kraus
Abstract: A collapsible container for a fluid that includes a flexible material, defining an internal working volume; at least one collapsible baffle adhered within the working volume of said collapsible container, the at least one baffle having one or more channels for delivering one or more fluids into the working volume via at least one hole in said one or more channels, one or more channels in said container for exiting or venting fluids from the working volume, and an impeller assembly disposed at least partially within said working volume of said container.
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