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公开(公告)号：US10723990B2
公开(公告)日：2020-07-28
申请号：US14782487
申请日：2014-03-17
Applicant: EMD Millipore Corporation
Inventor： Kara Der , Anne Hansen , James McSweeney , David Kraus , Jeffrey Pearsons , Amy Wood
Abstract: A container, such as a disposable or single use bioreactor, optionally having one or more inlets and one or more outlets and a mixer associated with the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The container includes a flexible baffle shaped and positioned within the container to improve mixing, particularly to improve low shear mixing. The baffle is positioned within the container so as to disrupt the vortex formed by the mixer, or prevent formation of a vortex. The baffle is shaped with both horizontal and vertical elements to enhance disruption of the vortex across the entire vessel height and provide homogeneous mixing throughout all operating volumes. In certain embodiments, the baffle is X-shaped.
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公开(公告)号：US20160244710A1
公开(公告)日：2016-08-25
申请号：US14915796
申请日：2014-10-03
Applicant: EMD MILLIPORE CORPORATION
Inventor： Amy Wood , Dave Kraus , Anne Hansen , Kara Der , James McSweeney
CPC classification number: C12M27/02 , B01F3/04269 , B01F3/04531 , B01F7/22 , B01F13/0863 , B01F15/0022 , B01F15/00344 , B01F15/0085 , B01F2003/04297 , B01F2003/04631 , B01F2003/04673 , B01F2215/0073 , C12M29/06 , C12Q3/00
Abstract: An aeration device, and containers or vessels incorporating the same. The aeration device can comprise a plurality of interchangeable aeration elements that can produce gas bubble of different sizes and deliver them to the contents of the container. Also disclosed are containers, such as a disposable or single-use container, optionally having one or more inlets and one or more outlets, an aeration device including a plurality of aeration elements, and a mixer to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The container can be a bioreactors and the aeration device controls the dissolved gas concentration content of the bioreactor contents, thereby facilitating proper growth of cell cultures in the bioreactor.
Abstract translation: 曝气装置，以及装有该装置的容器或容器。 曝气装置可以包括多个可互换曝气元件，其可以产生不同尺寸的气泡并将其输送到容器的内容物。 还公开了容器，例如一次性或一次性容器，可选地具有一个或多个入口和一个或多个出口，包括多个通气元件的曝气装置和用于引起混合，分散，均质化和/或 包含或添加到容器中的一种或多种成分的循环。 容器可以是生物反应器，曝气装置控制生物反应器内容物的溶解气体浓度含量，从而促进生物反应器中细胞培养物的适当生长。
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公开(公告)号：US20160040113A1
公开(公告)日：2016-02-11
申请号：US14782487
申请日：2014-03-17
Applicant: EMD Millipore Corporation
Inventor： Kara Der , Anne Hansen , James McSweeney , David Kraus , Jeffrey Pearsons , Amy Wood
Abstract: A container, such as a disposable or single use bioreactor, optionally having one or more inlets and one or more outlets and a mixer associated with the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The container includes a flexible baffle shaped and positioned within the container to improve mixing, particularly to improve low shear mixing. The baffle is positioned within the container so as to disrupt the vortex formed by the mixer, or prevent formation of a vortex. The baffle is shaped with both horizontal and vertical elements to enhance disruption of the vortex across the entire vessel height and provide homogeneous mixing throughout all operating volumes. In certain embodiments, the baffle is X-shaped.
Abstract translation: 一个容器，例如一次性或单次使用的生物反应器，任选地具有一个或多个入口和一个或多个出口以及与该容器相关联的混合器，以使包含或添加到一个或多个成分中的一种或多种成分混合，分散，均化和/或循环 容器 容器包括形状并定位在容器内的柔性挡板以改善混合，特别是改善低剪切混合。 挡板位于容器内，以便破坏由混合器形成的涡流，或防止形成涡流。 挡板被成形为具有水平和垂直元件，以增强跨越整个容器高度的涡流的破坏，并在整个操作体积中提供均匀的混合。 在某些实施例中，挡板是X形的。
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