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    DEVICE FOR BIND AND ELUTE CHROMATOGRAPHY USING MEMBRANES, AND METHOD OF MANUFACTURE
    1.
    发明申请
    DEVICE FOR BIND AND ELUTE CHROMATOGRAPHY USING MEMBRANES, AND METHOD OF MANUFACTURE 有权

    公开(公告)号：US20220032235A1

    公开(公告)日：2022-02-03

    申请号：US17432122

    申请日：2020-02-20

    Applicant: EMD Millipore Corporation

    Inventor： Kevin Rautio ,  Sean Foley ,  Stephen G. Hunt ,  Bumchul Lee ,  Nathan Landry

    IPC: B01D63/08

    Abstract: Single-use integral chromatography unit having an inlet and an outlet, and comprising one or more plates or pairs of filter plates interposable between a pair of end plates. In certain embodiments, each of the filter plates comprises a polymeric framework with one or more membranes supported therein. The filter plates and end plates may be assembled to form a substantially fixed, substantially water-tight, integral stack. Fluid entering the unit through a common inlet passes the membrane or membranes of each filter plate substantially contemporaneously prior to exiting the unit through a common outlet (cf, “parallel” flow). The assembly is a modular design, as multiple pairs of plates can be stacked in a suitable holder to form a single chromatography unit.

    Aseptic filter vent valve and port for integrity testing
    3.
    发明授权
    Aseptic filter vent valve and port for integrity testing 有权

    公开(公告)号：US10656046B2

    公开(公告)日：2020-05-19

    申请号：US15520082

    申请日：2015-12-17

    Applicant: EMD Millipore Corporation

    Inventor： Stephen G. Hunt ,  Nicholas Landry ,  Martin Szyk

    IPC: G01M3/28 ,  B01D65/10 ,  B01D65/02 ,  B01D61/24 ,  F16J15/00 ,  F16K1/46

    Abstract: The present disclosure relates to a filter capsule that supports direct integrity testing of an internal filter element. The filter capsule includes a filter housing having an inlet port, an outlet port, a passage running longitudinally between the inlet port and outlet port and holding a filter element, and an aseptic vent assembly. The filter housing also includes an integrity test assembly that can be used as a direct connection for integrity testing hardware, as opposed to upstream of the filter capsule. In one embodiment, the integrity test assembly comprises a body having a bore formed through its interior and a movable plunger within the bore. The plunger includes a handle to move the plunger between a closed position and an open position. Various seals between the plunger and the bore form a fluid tight seal between various portions of the plunger and the bore.

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