公开(公告)号：US20170319985A1

公开(公告)日：2017-11-09

申请号：US15608102

申请日：2017-05-30

Applicant: EMD Millipore Corporation

Inventor： Jeremy Perreault ,  Sean Foley ,  Kevin Rautio

IPC: B01D19/00 ,  A61L2/00 ,  B01D61/14 ,  B01D61/18 ,  B01D63/08

CPC classification number: B01D19/0031 ,  A61L2/0017 ,  B01D61/142 ,  B01D61/18 ,  B01D63/084 ,  B01D2313/16 ,  B01D2313/44 ,  B01D2315/08 ,  B01D2317/025 ,  B01D2317/06 ,  B01D2319/02 ,  B01D2325/36 ,  B01D2325/38

Abstract: Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more inputs for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.

公开(公告)号：US20220032235A1

公开(公告)日：2022-02-03

申请号：US17432122

申请日：2020-02-20

Applicant: EMD Millipore Corporation

Inventor： Kevin Rautio ,  Sean Foley ,  Stephen G. Hunt ,  Bumchul Lee ,  Nathan Landry

IPC: B01D63/08

Abstract: Single-use integral chromatography unit having an inlet and an outlet, and comprising one or more plates or pairs of filter plates interposable between a pair of end plates. In certain embodiments, each of the filter plates comprises a polymeric framework with one or more membranes supported therein. The filter plates and end plates may be assembled to form a substantially fixed, substantially water-tight, integral stack. Fluid entering the unit through a common inlet passes the membrane or membranes of each filter plate substantially contemporaneously prior to exiting the unit through a common outlet (cf, “parallel” flow). The assembly is a modular design, as multiple pairs of plates can be stacked in a suitable holder to form a single chromatography unit.

公开(公告)号：US20230302409A1

公开(公告)日：2023-09-28

申请号：US18034243

申请日：2021-11-16

Applicant: EMD Millipore Corporation

Inventor： Heejin Lee ,  Michael James Susienka ,  Johnathan Lawson ,  John Paul Amara ,  Joseph Michael Almasian ,  Sean Foley ,  James Ormond

IPC: B01D61/18 ,  B01D63/08

CPC classification number: B01D61/18 ,  B01D63/082 ,  B01D2313/54 ,  B01D2313/13 ,  B01D2313/105 ,  B01D2313/125 ,  B01D2313/16 ,  B01D2313/06 ,  B01D2313/041

Abstract: An apparatus for treating a biological fluid, comprising a plurality of filtration devices. In some embodiments, each of the plurality of filtration devices comprising at least one inlet and at least one outlet; and a first insert plate and a second insert plate opposite the first insert plate, wherein the plurality of filtration devices is disposed therebetween. In some embodiments, each filtration device has a vent port. A manifold for each of the inlets, outlets, and vent ports is optionally fluidly connected. In another embodiment, hose barb connectors or the like may be protected from damage and/or exposure by being recessed in the device or positioned at a periphery of the device. Embodiments include apparatus and methods to achieve dripless connect/disconnect and to reduce the number of sterile-to-sterile connections.

公开(公告)号：US09694304B2

公开(公告)日：2017-07-04

申请号：US14440370

申请日：2013-11-26

Applicant: EMD Millipore Corporation

Inventor： Jeremy Perreault ,  Sean Foley ,  Kevin Rautio

IPC: B01D19/00 ,  A61L2/00 ,  B01D61/14 ,  B01D61/18 ,  B01D63/08

CPC classification number: B01D19/0031 ,  A61L2/0017 ,  B01D61/142 ,  B01D61/18 ,  B01D63/084 ,  B01D2313/16 ,  B01D2313/44 ,  B01D2315/08 ,  B01D2317/025 ,  B01D2317/06 ,  B01D2325/36 ,  B01D2325/38

Abstract: Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more in-puts for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.

公开(公告)号：US10195544B2

公开(公告)日：2019-02-05

申请号：US15608102

申请日：2017-05-30

Applicant: EMD Millipore Corporation

Inventor： Jeremy Perreault ,  Sean Foley ,  Kevin Rautio

IPC: A61L2/00 ,  B01D19/00 ,  B01D61/14 ,  B01D61/18 ,  B01D63/08

Abstract: Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more inputs for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.

公开(公告)号：US20150283479A1

公开(公告)日：2015-10-08

申请号：US14440370

申请日：2013-11-26

Applicant: EMD MILLIPORE CORPORATION

Inventor： Jeremy Perreault ,  Sean Foley ,  Kevin Rautio

IPC: B01D19/00

CPC classification number: B01D19/0031 ,  A61L2/0017 ,  B01D61/142 ,  B01D61/18 ,  B01D63/084 ,  B01D2313/16 ,  B01D2313/44 ,  B01D2315/08 ,  B01D2317/025 ,  B01D2317/06 ,  B01D2325/36 ,  B01D2325/38

Abstract: Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more in-puts for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.

Abstract translation: 冗余过滤系统，其包括至少一个阻挡过滤器作为过程过滤器，该阻隔过滤器具有亲水和疏水路径，允许流体和气体渗透性。 消除了通风口的需要，中间排水过滤器也是如此。 该装置也可以串联干燥。 过滤系统包括管道和容器网络，网络在一端接收液体原料和/或起始材料，将其通过由其限定的工艺流进行，并在另一端产生所需的液体产物。 该网络具有一个或多个投入物，用于将液体原料引入流体工艺流中，以及一个或多个输出端口，用于将流体排出流体工艺流。 网络优选是基本上封闭的网络，并且优选地是无菌和/或无菌的。