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公开(公告)号：US20170107272A1
公开(公告)日：2017-04-20
申请号：US15340195
申请日：2016-11-01
CPC分类号： C07K16/00 , A61K48/00 , C07K2317/21 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/80 , C07K2317/82 , C07K2317/94 , G01N33/6857
摘要： Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.
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公开(公告)号：US20140171634A1
公开(公告)日：2014-06-19
申请号：US14185783
申请日：2014-02-20
IPC分类号： C07K16/24
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFα, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFα, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFα-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
摘要翻译： 本发明涉及特别稳定和可溶的scFv抗体和对TNFα特异性的Fab片段，其包含针对TNFα的稳定性，溶解性，体外和体内结合而优化的特异性轻链和重链序列以及低免疫原性。 所述抗体被设计用于诊断和/或治疗TNFα相关疾病。 还公开了用于表达本发明的重组抗体的核酸，载体和宿主细胞，用于分离它们的方法和所述抗体在医学中的用途。
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公开(公告)号：US10125186B2
公开(公告)日：2018-11-13
申请号：US15340195
申请日：2016-11-01
摘要： Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.
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4.发明授权Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same 有权表现出在细胞内环境中增强的稳定性的免疫球蛋白框架及鉴定其的方法公开(公告)号：US09518108B2
公开(公告)日：2016-12-13
申请号：US14469276
申请日：2014-08-26
CPC分类号： C07K16/00 , A61K48/00 , C07K2317/21 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/80 , C07K2317/82 , C07K2317/94 , G01N33/6857
摘要： Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.
摘要翻译： 提供组合物，其可用作产生非常稳定和可溶性单链Fv抗体片段的框架。 这些框架已经被选择用于细胞内性能，因此理想地适用于产生scFv抗体片段或scFv抗体文库，用于其中稳定性和溶解度是抗体片段表现的限制因素，例如在细胞的还原环境中。 此类框架还可用于鉴定高度保守的残基和共有序列，这些序列表现出增强的溶解度和稳定性。
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公开(公告)号：US09315572B2
公开(公告)日：2016-04-19
申请号：US14185783
申请日：2014-02-20
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFα, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFα, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFα-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
摘要翻译： 本发明涉及特别稳定和可溶的scFv抗体和对TNFα特异性的Fab片段，其包含针对TNFα的稳定性，溶解性，体外和体内结合而优化的特异性轻链和重链序列以及低免疫原性。 所述抗体被设计用于诊断和/或治疗TNFα相关疾病。 还公开了用于表达本发明的重组抗体的核酸，载体和宿主细胞，用于分离它们的方法和所述抗体在医学中的用途。
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6.发明申请公开(公告)号：US20150057191A1
公开(公告)日：2015-02-26
申请号：US14469276
申请日：2014-08-26
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , A61K48/00 , C07K2317/21 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/80 , C07K2317/82 , C07K2317/94 , G01N33/6857
摘要： Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.
摘要翻译： 提供组合物，其可用作产生非常稳定和可溶性单链Fv抗体片段的框架。 这些框架已经被选择用于细胞内性能，因此理想地适用于产生scFv抗体片段或scFv抗体文库，用于其中稳定性和溶解度是抗体片段表现的限制因素，例如在细胞的还原环境中。 此类框架还可用于鉴定高度保守的残基和共有序列，这些序列表现出增强的溶解度和稳定性。
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公开(公告)号：US08691228B2
公开(公告)日：2014-04-08
申请号：US13708500
申请日：2012-12-07
IPC分类号： A61K39/00
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFα, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFα, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFα-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
摘要翻译： 本发明涉及特别稳定和可溶的scFv抗体和对TNFα特异性的Fab片段，其包含针对TNFα的稳定性，溶解性，体外和体内结合而优化的特异性轻链和重链序列以及低免疫原性。 所述抗体被设计用于诊断和/或治疗TNFα相关疾病。 还公开了用于表达本发明的重组抗体的核酸，载体和宿主细胞，用于分离它们的方法和所述抗体在医学中的用途。
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公开(公告)号：US10570190B2
公开(公告)日：2020-02-25
申请号：US16175002
申请日：2018-10-30
IPC分类号： G01N33/543 , C07K16/00 , G01N33/68 , A61K48/00
摘要： Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.
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公开(公告)号：US20190119361A1
公开(公告)日：2019-04-25
申请号：US16175002
申请日：2018-10-30
摘要： Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.
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公开(公告)号：US09683034B2
公开(公告)日：2017-06-20
申请号：US15064067
申请日：2016-03-08
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFα, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFα, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFα-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
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