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公开(公告)号：US20240352062A1
公开(公告)日：2024-10-24
申请号：US18622013
申请日：2024-03-29
Applicant: Sanofi , Innate Pharma
Inventor： Thomas FRANCILLETTE , Benoit Mothes , Jérome Pezzini
CPC classification number: C07K1/22 , G01N33/6857 , C07K2317/31 , C07K2317/51 , C07K2317/524 , C07K2317/526 , C07K2319/30
Abstract: The invention relates to a method of purifying a heteromultimeric Fc domain-containing polypeptide, wherein the method comprises the following steps in the indicated order: providing a sample comprising the heteromultimeric Fc domain-containing polypeptide and one or more mispaired variants thereof; contacting a protein A chromatography matrix with the sample and binding the heteromultimeric Fc domain-containing polypeptide to the protein A chromatography matrix; contacting the protein A chromatography matrix with a wash solution, wherein the wash solution comprises octanoate; contacting the protein A chromatography matrix with an elution solution; and collecting an eluate comprising the heteromultimeric Fc domain-containing polypeptide. The invention further relates to the use of a buffer in said method, to a kit for performing said method, and to an eluate obtained by said method.
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公开(公告)号：US20240294618A1
公开(公告)日：2024-09-05
申请号：US18481129
申请日：2023-10-04
Applicant: Centivax, Inc.
Inventor： Jacob E. Glanville , Timothy Paul Friede , David Tsao , Sindy Andrea Liao Chan , I-Chieh Wang
IPC: C07K16/18 , A61K31/404 , A61K39/00 , A61P39/02 , G01N33/68
CPC classification number: C07K16/18 , A61K31/404 , A61P39/02 , G01N33/6857 , A61K2039/505 , C07K2317/565 , C07K2317/76 , G01N2333/4616 , G01N2333/4646
Abstract: This disclosure provides antibodies and antigen-binding fragments that can be administered to a subject that has been bitten by a venomous snake. Antibodies and antigen-binding fragments herein can be capable of treating or curing the subject and may provide protection against snake venom for up to several weeks. A combination or population of antibodies and antigen-binding fragments can be administered to the subject where the type of snake is not known or where a subject has been bitten by more than one species of snake. This disclosure further provides methods for identification of such broadly-neutralizing antibodies.
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公开(公告)号：US20240247054A1
公开(公告)日：2024-07-25
申请号：US18417299
申请日：2024-01-19
Applicant: MABWELL THERAPEUTICS, INC.
Inventor： Yubin WANG , Lei HUANG , Xin DU
CPC classification number: C07K16/18 , A61P25/28 , G01N33/6857 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/70
Abstract: The present disclosure provides anti-amyloid β (Aβ) antibodies and antibody fragments that preferentially bind soluble amyloid Aβ protofibril/oligomer and trigger ADPC in microglial cells, anti-amyloid β (Aβ) antibodies and antibody fragments that reduce soluble amyloid Aβ protofibril/oligomer levels and insoluble amyloid Aβ plaque in brain tissue, and the use of anti-Aβ protofibril/oligomer antibodies and antibody fragments in therapy, prophylaxis, diagnosis, screening, and monitoring of conditions associated with Aβ protein aggregation, in particular Alzheimer's disease (AD).
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公开(公告)号：US11977081B2
公开(公告)日：2024-05-07
申请号：US16954918
申请日：2018-12-18
Applicant: REGENERON PHARMACEUTICALS, INC.
Inventor： Viktoria Gusarova , Jesper Gromada , Andrew J. Murphy
CPC classification number: G01N33/6857 , G01N2800/044
Abstract: The present invention provides ELISA-based methods for detecting and/or quantifying ANGPTL8 in biological samples using anti-ANGPTL8 antibodies.
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公开(公告)号：US11835520B2
公开(公告)日：2023-12-05
申请号：US16472269
申请日：2017-12-21
Inventor： Ivo Mueller , Takafumi Tsuboi , Michael White , Rhea Longley
IPC: G01N33/573 , G01N33/569 , C07K14/415 , C07K16/20 , G01N33/68
CPC classification number: G01N33/56905 , C07K14/415 , C07K16/205 , G01N33/6857 , G01N2333/445
Abstract: A system, method, apparatus and diagnostic test for Plasmodium vivax, to determine a likelihood of a specific timing of infection by P. vivax in a subject, and hence identify individuals with a high probability of being infected with otherwise undetectable liver-stage hypnozoites. The system, method, apparatus and diagnostic test relate to the identification of hypnozoites (“dormant” liver-stages), or at least of the likelihood of the subject being so infected. Optionally and preferably, the specific timing relates to recent infections, for example within the last 9 months.
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Patent Agency Ranking
公开(公告)号：US20230374156A1
公开(公告)日：2023-11-23
申请号：US18122948
申请日：2023-03-17
Applicant: JANSSEN BIOTECH, INC.
Inventor： Sanjaya SINGH , Rajkumar GANESAN , Jun CHEN , Iqbal S. GREWAL
CPC classification number: C07K16/42 , G01N33/6857 , C07K2317/14 , C07K2317/34
Abstract: Molecules, including antibodies and antigen-binding fragments thereof that specifically bind to a linker peptide, and methods of producing and using the described antibodies and antigen-binding fragments are presented herein. Also presented herein methods of generating antibodies that specifically bind to an immunorecessive epitope.
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公开(公告)号：US20230349919A1
公开(公告)日：2023-11-02
申请号：US18184054
申请日：2023-03-15
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Brian Klotz , Seblewongel Asrat , Marion Francis Setliff , Andrea Vecchione , Joseph Cooper Devlin , Wei Keat Lim , Samuel Davis , Hang Song , Jamie Orengo , Gurinder Atwal , Matthew Sleeman , Wen-yi Lee , Gang Chen , Kristel Velez
IPC: G01N33/68
CPC classification number: G01N33/6857
Abstract: The present disclosure provides antibody capture complexes and methods of capturing a target antibody secreted by an antibody secreting cell.
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公开(公告)号：US20230265155A1
公开(公告)日：2023-08-24
申请号：US18193830
申请日：2023-03-31
Inventor： Celine MONNET , Philippe MONDON , Alexandre FONTAYNE , Christophe DE ROMEUF
IPC: C07K14/735 , C07K16/28 , C07K16/00 , A61K39/395 , G01N33/53 , G01N33/68
CPC classification number: C07K14/70535 , C07K16/2803 , C07K16/00 , A61K39/395 , C07K16/2887 , G01N33/53 , G01N33/6857 , C07K2317/524 , C07K2317/21 , C07K2317/734 , C07K2317/71 , C07K2317/732 , C07K2317/72 , C07K2317/41 , C07K2317/526 , C07K2317/24 , C07K2317/53 , C07K2319/30
Abstract: Disclosed is a polypeptide including a mutated Fc region and having functional activity, mediated by the Fc region, that is modified compared with that of a parent polypeptide. The Fc region includes at least one combination of 2 mutations, the combination being selected from among one mutation selected from among a first set of mutations, and at least one mutation selected from among a second set of mutations, and provided that mutation (i) does not take place on the same amino acid as mutation (ii). Also disclosed are use of the polypeptide, compositions including the same, and methods for preparing the polypeptide.
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公开(公告)号：US11733247B2
公开(公告)日：2023-08-22
申请号：US16604933
申请日：2018-04-13
Applicant: Micromass UK Limited
Inventor： Stevan Bajic , Jeffery Mark Brown
CPC classification number: G01N33/6857 , G01N30/7266 , G01N33/6848 , H01J49/0068 , H01J49/045 , H01J49/062 , H01J49/165 , H01J49/168
Abstract: A method of ionising a sample is disclosed comprising nebulising a sample which includes first biomolecules such as bovine insulin comprising one or more disulphide (S—S) bonds. A stream of droplet or charged droplets comprising one or more disulphide (S—S) bonds is directed so as to impact upon a target (106) or electrode so as to cause the breaking of a portion of the disulphide bonds. Alternatively, charged droplets may pass through an electric field region determined by an electrode (106) arranged downstream of a nebuliser or electrospray probe and an ion inlet (104) of a mass spectrometer so as to cause the breaking of a portion of the disulphide bonds.
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公开(公告)号：US11718662B2
公开(公告)日：2023-08-08
申请号：US16376154
申请日：2019-04-05
Inventor： Harald Zur Hausen , Ethel-Michele De Villiers-Zur Hausen , Timo Bund , Sebastian Eilebrecht
IPC: G01N33/543 , C07K16/18 , G01N33/563 , G01N33/577 , G01N33/68 , G01N33/53 , G01N33/564 , G01N33/50
CPC classification number: C07K16/18 , G01N33/502 , G01N33/53 , G01N33/563 , G01N33/564 , G01N33/577 , G01N33/6857 , G01N2496/80 , G01N2800/285
Abstract: Disclosed is a method of diagnosing multiple sclerosis (MS), wherein a blood sample from a patient is incubated with a DNA-replication associated (REP) protein. The present invention relates to a DNA-replication-associated (Rep) protein for use in the diagnosis of multiple sclerosis (MS), wherein (a) an increased amount of Rep protein or fragments thereof in the sample as compared to an amount in a control sample; or an increased amount of anti-Rep protein antibodies with antigen in a sample from a subject as compared to an amount in a control sample correlates with a diagnosis of MS, wherein the Rep protein is MSBI1 Rep or MSBI2 Rep.
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