公开(公告)号：US20230399674A1

公开(公告)日：2023-12-14

申请号：US18032312

申请日：2021-10-22

Applicant: ERBER AKTIENGESELLSCHAFT

Inventor： Wulf-Dieter Moll ,  Barbara Weber ,  Martin Siller

IPC: C12P41/00 ,  A23K20/147 ,  A23K20/189 ,  A23L5/20 ,  A23L33/18 ,  C12N9/04

CPC classification number: C12P41/00 ,  A23K20/147 ,  A23K20/189 ,  A23L5/25 ,  A23L33/18 ,  C12N9/0006 ,  C12Y101/01001

Abstract: The present invention relates to means and methods for degrading DON and/or DON derivative/s comprising a polypeptide comprising an amino acid sequence having at least 70% identity to the amino acid sequence set forth in SEQ ID NO: 1.

公开(公告)号：US20230235297A1

公开(公告)日：2023-07-27

申请号：US18008939

申请日：2021-06-08

Applicant: ERBER AKTIENGESELLSCHAFT

Inventor： Bernhard Neumayer ,  Elisabeth Streit ,  Barbara Weber ,  Gudrun Vogtentanz

IPC: C12N9/02 ,  A23K20/189 ,  A23L29/00

CPC classification number: C12N9/0008 ,  A23K20/189 ,  A23L29/06 ,  C12Y197/00

Abstract: The present invention relates to a method of converting 3-keto-DON into 3-epi-DON, reducing the content of DON in a composition comprising DON or of reducing the toxicity of a composition comprising DON as well as a method for converting a trichothecene comprising a 3-oxo group into a trichothecene comprising a 3-hydroxy group using one or more polypeptide(s) comprising or consisting of SEQ ID NO. 1 or a sequence having a sequence identity of at least 72.0% to SEQ ID NO. 1. Also envisioned are feed or food additives or feed or food as well as pharmaceutical compositions comprising one or more polypeptide(s) comprising or consisting of a sequence of SEQ ID NO. 1 or a sequence having a sequence identity of at least 72.0% to SEQ ID NO. 1 as well as the manufacture thereof. Encompassed are further polypeptide(s) comprising or consisting of a sequence of SEQ ID NO. 1 or a sequence having a sequence identity of at least 88.5% to SEQ ID NO. 1. Also envisioned are host cells or plants.

公开(公告)号：US20200010812A1

公开(公告)日：2020-01-09

申请号：US16576811

申请日：2019-09-20

Applicant: Erber Aktiengesellschaft

Inventor： Eva-Maria BINDER ,  Barbara Weber ,  Claudia Bernard

IPC: C12N9/04 ,  A23K50/60 ,  A23K10/14

Abstract: An alcohol dehydrogenase of sequence ID numbers 2, 3 or 4 containing metal ions and a quinone cofactor, or in addition, a functional variant exhibiting a sequence identity of at least 80%, preferably at least 86%, especially preferred at least 89% and at least one redox cofactor for the transformation of at least one trichothecene exhibiting a hydroxyl group on the C-3 atom, as well as a method for the enzymatic transformation of trichothecenes and a trichothecene-transforming additive.

公开(公告)号：US10526585B2

公开(公告)日：2020-01-07

申请号：US15561545

申请日：2015-03-27

Applicant: Erber Aktiengesellschaft

Inventor： Eva-Maria Binder ,  Barbara Weber ,  Claudia Bernard

IPC: C12N9/04 ,  A61K38/44 ,  A23K10/14 ,  A23K50/60

Abstract: A alcohol dehydrogenase of sequence ID no. 1 containing metal ions and a quinone cofactor, or in addition, a functional variant exhibiting a sequence identity of at least 80%, preferably at least 86%, especially preferred at least 89% and at least one redox cofactor for the transformation of at least one trichothecene exhibiting a hydroxyl group on the C-3 atom, as well as a method for the enzymatic transformation of trichothecenes and a trichothecene-transforming additive.

公开(公告)号：US20220372450A1

公开(公告)日：2022-11-24

申请号：US17638756

申请日：2020-08-28

Applicant: ERBER AKTIENGESELLSCHAFT

Inventor： Bernhard Neumayer ,  Elisabeth Streit ,  Barbara Weber ,  Gudrun Vogtentanz

IPC: C12N9/02 ,  A61K47/02

Abstract: The present invention relates to compositions comprising one or more polypeptide(s) comprising or consisting of a sequence of SEQ ID NO. 1-14 or a sequence having a sequence identity of at least 75% to any one of SEQ ID NO. 1-14 and a carrier as well as uses and methods of these polypeptides.

公开(公告)号：US11001812B2

公开(公告)日：2021-05-11

申请号：US16576811

申请日：2019-09-20

Applicant: Erber Aktiengesellschaft

Inventor： Eva-Maria Binder ,  Barbara Weber ,  Claudia Bernard

IPC: C12N9/04 ,  A61K38/44 ,  A23K10/14 ,  C12N9/02 ,  A23K50/80 ,  A23K50/60

Abstract: An alcohol dehydrogenase of sequence ID numbers 2, 3 or 4 containing metal ions and a quinone cofactor, or in addition, a functional variant exhibiting a sequence identity of at least 80%, preferably at least 86%, especially preferred at least 89% and at least one redox cofactor for the transformation of at least one trichothecene exhibiting a hydroxyl group on the C-3 atom, as well as a method for the enzymatic transformation of trichothecenes and a trichothecene-transforming additive.