公开(公告)号：US12258587B2

公开(公告)日：2025-03-25

申请号：US17295287

申请日：2019-11-20

Applicant: Exosome Diagnostics, Inc.

Inventor： Georg Stoll ,  Daniel Enderle ,  Mikkel Noerholm ,  Johan Karl Olov Skog

IPC: C12N15/10 ,  C12N7/00 ,  C12Q1/6806 ,  C12Q1/6851 ,  C12Q1/70

Abstract: The present disclosure provides compositions, methods and kits for internal controls of microvesicle isolations. The compositions, methods and kits can comprise enveloped viruses, including, but not limited to, inactive mouse hepatitis virus (MHV).

公开(公告)号：US10808240B2

公开(公告)日：2020-10-20

申请号：US16301176

申请日：2017-05-15

Applicant: Exosome Diagnostics, Inc.

Inventor： Georg Stoll ,  Daniel Enderle ,  Mikkel Noerholm ,  Johan Karl Olov Skog

IPC: C12N15/10 ,  C12N15/11 ,  C07H1/06

Abstract: The invention provides novel methods and kits for fully automated high-throughput method for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles, novel methods and kits for isolation of extracellular vesicles and co-isolation of cell-free DNA from biofluids, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles that do not require the use of phenol or chloroform, and for extracting nucleic acids from the extracellular vesicles and/or from the biological samples.