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公开(公告)号：US20220111052A1
公开(公告)日：2022-04-14
申请号：US17557755
申请日：2021-12-21
摘要： The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.
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公开(公告)号：US20140231653A1
公开(公告)日：2014-08-21
申请号：US14348098
申请日：2012-10-01
CPC分类号： G01T1/2006 , G01N30/62 , G01N2030/77 , G01T1/003 , G01T7/02
摘要： The present invention provides a flow cell that can be used to improve the linear detection range of a radio-detector. The flow cell of the present invention is simple and cost-effective to set up and provides technical advantages over methods known in the prior art, as set out in more detail hereunder. The present invention also provides a method to determine the RCP of a radioactive composition making use of said flow cell, and a HPLC system comprising said flow cell.
摘要翻译： 本发明提供了可用于改善无线电检测器的线性检测范围的流动池。 与现有技术中已知的方法相比，本发明的流动池相对于现有技术中已知的方法而言，设置简单且成本有效，并且提供了技术优点，如下文更详细地阐述。 本发明还提供了确定使用所述流动池的放射性组合物的RCP的方法，以及包括所述流动池的HPLC系统。
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公开(公告)号：US11534494B2
公开(公告)日：2022-12-27
申请号：US16997188
申请日：2020-08-19
摘要： The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.
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公开(公告)号：US09383456B2
公开(公告)日：2016-07-05
申请号：US14348098
申请日：2012-10-01
CPC分类号： G01T1/2006 , G01N30/62 , G01N2030/77 , G01T1/003 , G01T7/02
摘要： The present invention provides a flow cell that can be used to improve the linear detection range of a radio-detector. The flow cell of the present invention is simple and cost-effective to set up and provides technical advantages over methods known in the prior art, as set out in more detail hereunder. The present invention also provides a method to determine the RCP of a radioactive composition making use of said flow cell, and a HPLC system comprising said flow cell.
摘要翻译： 本发明提供了可用于改善无线电检测器的线性检测范围的流动池。 与现有技术中已知的方法相比，本发明的流动池相对于现有技术中已知的方法而言，设置简单且成本有效，并且提供了技术优点，如下文更详细地阐述。 本发明还提供了确定使用所述流动池的放射性组合物的RCP的方法，以及包括所述流动池的HPLC系统。
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公开(公告)号：US11077216B2
公开(公告)日：2021-08-03
申请号：US15318599
申请日：2015-06-30
IPC分类号： A61K51/00 , A61M36/14 , A61K51/04 , C07B59/00 , C07C227/20
摘要： The present invention provides a composition comprising anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid (18F-FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain said composition.
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公开(公告)号：US20210030878A1
公开(公告)日：2021-02-04
申请号：US16997188
申请日：2020-08-19
摘要： The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.
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公开(公告)号：US20220001034A1
公开(公告)日：2022-01-06
申请号：US17366681
申请日：2021-07-02
IPC分类号： A61K51/04 , C07B59/00 , C07C227/20
摘要： The present invention provides a composition comprising anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid (18F-FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain said composition.
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公开(公告)号：US20170128597A1
公开(公告)日：2017-05-11
申请号：US15318599
申请日：2015-06-30
IPC分类号： A61K51/04 , C07B59/00 , C07C227/20
CPC分类号： A61K51/0402 , C07B59/001 , C07B2200/05 , C07C227/20 , C07C2601/04
摘要： The present invention provides a composition comprising anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid (18F-FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain said composition.
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