公开(公告)号：US11180572B2

公开(公告)日：2021-11-23

申请号：US14413178

申请日：2013-07-05

Applicant: GENMAB B.V.

Inventor： Rob N. De Jong ,  Frank Beurskens ,  Paul Parren ,  Aran Frank Labrijn ,  Janine Schuurman ,  Arjen Vlug ,  Sandra Verploegen

IPC: C07K16/00 ,  A61K39/395 ,  C07K16/28 ,  C07K16/30 ,  C07K16/40 ,  C07K16/32 ,  C07K16/10 ,  C07K16/36 ,  C07K16/12 ,  A61K39/00

Abstract: The present invention relates to dimeric proteins comprising amino acids at three different positions which are different from those present in a human IgG1. Six of said dimeric proteins are capable of forming a hexameric structure in solution.

公开(公告)号：US20150175707A1

公开(公告)日：2015-06-25

申请号：US14413178

申请日：2013-07-05

Applicant: GENMAB B.V.

Inventor： Rob N. De Jong ,  Frank Beurskens ,  Paul Parren ,  Aran Frank Labrijn ,  Janine Schuurman ,  Arjen Vlug ,  Sandra Verploegen

IPC: C07K16/40 ,  C07K16/12 ,  C07K16/28

Abstract: The present invention relates to dimeric proteins comprising amino acids at three different positions which are different from those present in a human IgG1. Six of said dimeric proteins are capable of forming a hexameric structure in solution.

Abstract translation: 本发明涉及包含不同于存在于人IgG1中的三个不同位置的氨基酸的二聚体蛋白质。 所述二聚体蛋白中的六个能够在溶液中形成六聚体结构。