公开(公告)号：US3983103A

公开(公告)日：1976-09-28

申请号：US595593

申请日：1975-07-14

申请人： Gabrijela Kobrehel ,  Zrinka Tamburasev ,  Slobodan Djokic

发明人： Gabrijela Kobrehel ,  Zrinka Tamburasev ,  Slobodan Djokic

IPC分类号： C07H17/08 ,  C07H15/20

CPC分类号： C07H17/08

摘要： The new antibiotic compounds N-(4-R-benzenesulfonyl)-erythromycylamine, wherein R is a lower alkyl group having 1-5 carbon atoms, an acylamino group wherein the acyl has 2-4 carbon atoms, or a halo group.

摘要翻译： 新的抗生素化合物N-（4-R-苯磺酰基） - 红霉素胺，其中R是具有1-5个碳原子的低级烷基，酰基具有2-4个碳原子的酰基氨基或卤代基。

公开(公告)号：US4328334A

公开(公告)日：1982-05-04

申请号：US134816

申请日：1980-03-28

申请人： Gabrijela Kobrehel ,  Gordana Radobolja ,  Zrinka Tamburasev ,  Slobodan Djokic

发明人： Gabrijela Kobrehel ,  Gordana Radobolja ,  Zrinka Tamburasev ,  Slobodan Djokic

IPC分类号： C07H17/08 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/00 ,  A61K31/71

CPC分类号： C07H17/00

摘要： 11-aza-10-deoxo-10-dihydroerythromycin A and derivatives thereof, and process for preparation thereof.

摘要翻译： 11-氮杂-10-脱氧-10-二氢红霉素A及其衍生物及其制备方法。

公开(公告)号：US4160783A

公开(公告)日：1979-07-10

申请号：US855496

申请日：1977-11-28

申请人： Marica Cakara ,  Slobodan Djokic ,  Zrinka Tamburasev

发明人： Marica Cakara ,  Slobodan Djokic ,  Zrinka Tamburasev

IPC分类号： A61K31/18 ,  A61K31/65 ,  C07C311/15 ,  C07C143/79

CPC分类号： A61K31/18 ,  A61K31/65 ,  C07C311/15

摘要： Novel 4-dedimethylamino-4-arylsulfonamido-5a,6-anhydrotetracyclines of the general formula I ##STR1## wherein R stands for C.sub.1 -C.sub.3 -alkyl, halogen or --NHCOR.sup.1, R.sup.1 being C.sub.1 -C.sub.3 -alkyl.

摘要翻译： 通式Ⅰ的新型4-脱二甲基氨基-4-芳基亚磺酰基-5a，6-脱水四环素其中R代表C 1 -C 3烷基，卤素或-NHCOR 1，R 1是C 1 -C 3烷基。

公开(公告)号：US3939144A

公开(公告)日：1976-02-17

申请号：US540151

申请日：1975-01-10

申请人： Gorjana Radobolja ,  Zrinka Tamburasev ,  Slobodan Djokic

发明人： Gorjana Radobolja ,  Zrinka Tamburasev ,  Slobodan Djokic

IPC分类号： C07H17/08 ,  C07H15/22

CPC分类号： C07H17/08

摘要： N-(4-R.sup.2 -benzenesulfonyl)-5-O-desosaminyl-erythromycilamine, wherein R.sup.2 is a C.sub.1 -C.sub.5 alkyl radical, halogen or NH.sub.2. The compounds possess antibacterial activity.

摘要翻译： N-（4-R 2 - 苯磺酰基）-5-O-去酰胺基 - 红霉素胺，其中R2是C1-C5烷基，卤素或NH2。 该化合物具有抗菌活性。

公开(公告)号：US5434140A

公开(公告)日：1995-07-18

申请号：US178559

申请日：1994-01-07

申请人： Gabrijela Kobrehel ,  Gorjana Lazarevski ,  Slobodan Djokic

发明人： Gabrijela Kobrehel ,  Gorjana Lazarevski ,  Slobodan Djokic

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61P31/04 ,  C07H17/00 ,  C07H17/08

CPC分类号： C07H17/08 ,  C07H17/00

摘要： The invention relates to 9-deoxo-9a-aza-11-deoxy-9a-homoerythromycin A 9a,11-cyclic carbamates, novel semisynthetic macrolide antibiotics from the genus of azalides, of the formula (I) ##STR1## whereinR.sup.1 .dbd.R.sup.2 .dbd.CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 .dbd.R.sup.4 .dbd.CH.sub.3, (IA)R.sup.1 .dbd.R.sup.2 .dbd.CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 .dbd.CH.sub.3, R.sup.4 .dbd.H, (IB)R.sup.1 .dbd.R.sup.2 .dbd.CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 .dbd.R.sup.4 .dbd.H, (IC)R.sup.1 .dbd.R.sup.2 .dbd.H, R.sup.3 .dbd.R.sup.4 .dbd.CH.sub.3,(ID)R.sup.1 .dbd.R.sup.2 .dbd.R.sup.4 .dbd.H, R.sup.3 .dbd.CH.sub.3,(IE)R.sup.1 .dbd.R.sup.2 .dbd.R.sup.3 .dbd.R.sup.4 .dbd.H, (IF)R.sup.1 .dbd.H, R.sup.2 .dbd.R.sup.3 .dbd.R.sup.4 .dbd.CH.sub.3,(IG)R.sup.1 .dbd.R.sup.4 .dbd.H, R.sup.2 .dbd.R.sup.3 .dbd.CH.sub.3,(IH)R.sup.1 .dbd.R.sup.3 .dbd.R.sup.4 .dbd.H, R.sup.2 .dbd.CH.sub.3,(IJ)to pharmaceutically acceptable addition salts thereof with inorganic or organic acids, to intermediates and to processes for the preparation thereof, to a process for preparing pharmaceutical compositions as well as to the use of the obtained pharmaceutical compositions in treatment of bacterial infections.

摘要翻译： 本发明涉及9-脱氧-9a-氮杂-11-脱氧-9a-高红霉素A 9a,11-环状氨基甲酸酯，由式（I）的化合物制备的新的半合成大环内酯类抗生素，其中R1 = R2 = CO 2 CH 2 C 6 H 5，R 3 = R 4 = CH 3，（IA）R 1 = R 2 = CO 2 CH 2 C 6 H 5，R 3 = CH 3，R 4 = H，（IB）R 1 = R 2 = CO 2 CH 2 C 6 H 5， R3 = R4 = CH3，（ID）R1 = R2 = R4 = H，R3 = CH3，（IE）R1 = R2 = R3 = R4 = H，（IF）R1 = H，R2 = R3 = R4 = CH3，（ IG）R1 = R4 = H，R2 = R3 = CH3，（1H）R1 = R3 = R4 = H，R2 = CH3，（IJ）与其与无机或有机酸的药学上可接受的加成盐， 制备药物组合物的方法以及所获得的药物组合物在细菌感染治疗中的用途。

公开(公告)号：US5250518A

公开(公告)日：1993-10-05

申请号：US731781

申请日：1991-07-18

申请人： Gabrijela Kobrehel ,  Slobodan Djokic ,  Gorjana Lazarevski

发明人： Gabrijela Kobrehel ,  Slobodan Djokic ,  Gorjana Lazarevski

IPC分类号： C07H17/00 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61P31/04 ,  C07D413/14 ,  C07H17/02 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The invention relates to O-methyl derivatives of azithromycin A of the formula (I) ##STR1## wherein Ia R.sup.1 =R.sup.2 =CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 =CH.sub.3, R.sup.4 =R.sup.5 =HIb R.sup.1 =R.sup.2 =CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 =R.sup.4 =CH.sub.3, R.sup.5 =HIc R.sup.1 =R.sup.2 =CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 =R.sup.5 =H, R.sup.4 =C.sub.3Id R.sup.1 =R.sup.2 =CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 =R.sup.4 =R.sup.5 =CH.sub.3Ie R.sup.1 =R.sup.2 =R.sup.4 =R.sup.5 =H, R.sup.3 =CH.sub.3If R.sup.1 =R.sup.2 =R.sup.5 =H, R.sup.3 =R.sup.4 =CH.sub.3Ig R.sup.1 =R.sup.2 =R.sup.3 =R.sup.5 =H, R.sup.4 =CH.sub.3Ih R.sup.1 =R.sup.2 =H, R.sup.3 =R.sup.4 =R.sup.5 =CH.sub.3Ii R.sup.1 =R.sup.4 =R.sup.5 =H, R.sup.2 =R.sup.3 =CH.sub.3Ij R.sup.1 =R.sup.5 =H, R.sup.2 =R.sup.3 =R.sup.4 =CH.sub.3Ik R.sup.1 =R.sup.3 =R.sup.5 =H, R.sup.2 =R.sup.4 =CH.sub.3Il R.sup.1 =H, R.sup.2 =R.sup.3 =R.sup.4 =R.sup.5 =CH.sub.3to their pharmaceutically acceptable addition salts with inorganic or organic acids, to a process for their preparation and to their use in the obtaining of antibacterial pharmaceutical preparations.

公开(公告)号：US4886792A

公开(公告)日：1989-12-12

申请号：US180491

申请日：1988-04-12

申请人： Slobodan Djokic ,  Nevenka Lopotar ,  Gabrijela Kobrehel ,  Hrvoje Krnjevic ,  Olga Carevic

发明人： Slobodan Djokic ,  Nevenka Lopotar ,  Gabrijela Kobrehel ,  Hrvoje Krnjevic ,  Olga Carevic

IPC分类号： A61K31/395 ,  A61P29/00 ,  C07D267/00 ,  C07D273/01

CPC分类号： C07D267/00

摘要： 10-dihydro-10-deoxo-11-azaerythronolide A compounds and pharmaceutically acceptable acid addition salts of said compounds; methods and intermediates for the manufacture thereof; their use as antiinflammatory agents and processes for their preparation.

公开(公告)号：US4517359A

公开(公告)日：1985-05-14

申请号：US304481

申请日：1981-09-22

申请人： Gabrijela Kobrehel ,  Slobodan Djokic

发明人： Gabrijela Kobrehel ,  Slobodan Djokic

IPC分类号： C07H17/08 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/00

CPC分类号： C07H17/00

摘要： 11-Methyl-11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one and derivatives thereof, such as the 13,14-carbonate and C.sub.1 -C.sub.3 -alkanoyl derivatives thereof. The compounds exhibit antibacterial activity.

摘要翻译： 11-甲基-11-氮杂-4-0-多角苷基-6-0-脱谷氨基-15-乙基-7,13,14-三羟基-3,5,7,9,12,14-六甲基氧环十五烷-2 - 酮及其衍生物，例如其13,14-碳酸酯和C 1 -C 3 - 烷酰基衍生物。 该化合物具有抗菌活性。

公开(公告)号：US5023240A

公开(公告)日：1991-06-11

申请号：US180940

申请日：1988-04-13

申请人： Amalija Narandja ,  Bozidar Suskovic ,  Slobodan Djokic ,  Nevenka Lopotar

发明人： Amalija Narandja ,  Bozidar Suskovic ,  Slobodan Djokic ,  Nevenka Lopotar

IPC分类号： A01N43/04 ,  A01P1/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

CPC分类号： C07H17/08

摘要： Derivatives of tylosin and 10,11,12,13-tetrahydro tylosin of the general formula ##STR1## wherein R stands for CHO, CH.sub.2 OH, CH.dbd.NOH or CH(OCH.sub.3).sub.2,R.sup.1 stands for H,R.sup.2 stands for OH orR.sup.1 +R.sup.2 stand for .dbd.O or .dbd.NOH,R.sup.3 stands for a mycarosyl group or a hydrogen atom, and stands for a single or a double bond;methods for the manufacture thereof; their use as antimicrobial agents and processes for the preparation of the latter.

公开(公告)号：US5268462A

公开(公告)日：1993-12-07

申请号：US669728

申请日：1991-03-14

申请人： Gorjana Lazarevski ,  Slobodan Djokic

发明人： Gorjana Lazarevski ,  Slobodan Djokic

IPC分类号： A61K31/395 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

CPC分类号： C07H17/08

摘要： Oleandomycin oximes ##STR1## wherein R.sup.1 stands for hydrogen or --CH.sub.3, R.sup.2 stands for --CH.sub.3 or hydrogen or R.sup.1 and R.sup.2 stand together for an epoxide group or for .dbd.CH.sub.2, R.sup.3 stands for --OH, whereas the line stands for a single or a double bond, a process for the preparation thereof and their use in antimicrobial agents.