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公开(公告)号：US11833356B2
公开(公告)日：2023-12-05
申请号：US15999524
申请日：2017-02-17
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Bo Lu , Brian Marc Pepin
CPC classification number: A61N1/36135 , A61N1/0556 , A61N1/0558 , A61N1/37229
Abstract: An electrode system for neuromodulation and for recording of signals indicative of nerve activity is provided. The system can include a plurality of electrodes provided on a flexible, non-conductive substrate. The substrate can be rolled into a cuff for encircling a nerve bundle of a patient. The plurality of electrodes on the cuff can be interconnected using flexible conductors provided on the substrate. In one implementation, the electrodes can be interconnected using conductors that have spring-like configuration. Flexibility of the conductors allows the cuff to expand and contract with the nerve without causing excessive stress/strain at the nerve-cuff interface.
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公开(公告)号：US11167143B2
公开(公告)日：2021-11-09
申请号：US16485673
申请日：2018-02-12
Applicant: Galvani Bioelectronics Limited
Inventor： Brian Marc Pepin , Shiv Sabesan
Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.
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公开(公告)号：US12023486B2
公开(公告)日：2024-07-02
申请号：US17690974
申请日：2022-03-09
Applicant: Galvani Bioelectronics Limited
Inventor： Brian Marc Pepin , Brian Otis
IPC: A61N1/05 , A61N1/36 , A61N1/372 , A61N1/378 , H02J7/02 , H02J7/34 , H02J50/10 , H02J50/20 , H02J50/80
CPC classification number: A61N1/0556 , A61N1/36139 , A61N1/3614 , A61N1/36178 , A61N1/36192 , A61N1/37229 , A61N1/3787 , H02J7/02 , H02J7/345 , H02J50/10 , H02J50/20 , H02J50/80
Abstract: Systems and methods are provided for stimulating one or more nerves with an implantable device. The implantable device may comprise an antenna circuit including a loop antenna and a control circuit including a rectifying diode for rectifying an alternating voltage induced in the antenna circuit by an external electromagnetic field. The implantable device may also include a chargeable storage element for storing energy from the rectified voltage without using a battery. The device may also include an electrode array containing a set of electrodes for emitting an electric field using the stored energy in response to a control signal received from the control circuit. The components of the device may be affixed onto a soft polymer substrate including a linkable peripheral tab on at least two edges of a substantially rectangular body section of the substrate for forming a cuff about the one or more nerves to be stimulated.
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公开(公告)号：US11298544B2
公开(公告)日：2022-04-12
申请号：US15999427
申请日：2017-02-17
Applicant: Galvani Bioelectronics Limited
Inventor： Brian Marc Pepin , Brian Otis
IPC: A61N1/36 , A61N1/05 , A61N1/372 , A61N1/378 , H02J50/10 , H02J50/20 , H02J50/40 , H02J50/80 , H02J7/02 , H02J7/34
Abstract: Systems and methods are provided for stimulating one or more nerves with an implantable device. The implantable device may comprise an antenna circuit including a loop antenna and a control circuit including a rectifying diode for rectifying an alternating voltage induced in the antenna circuit by an external electromagnetic field. The implantable device may also include a chargeable storage element for storing energy from the rectified voltage without using a battery. The device may also include an electrode array containing a set of electrodes for emitting an electric field using the stored energy in response to a control signal received from the control circuit. The components of the device may be affixed onto a soft polymer substrate including a linkable peripheral tab on at least two edges of a substantially rectangular body section of the substrate for forming a cuff about the one or more nerves to be stimulated.
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