公开(公告)号：US11167143B2

公开(公告)日：2021-11-09

申请号：US16485673

申请日：2018-02-12

Applicant: Galvani Bioelectronics Limited

Inventor： Brian Marc Pepin ,  Shiv Sabesan

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/375

Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.

公开(公告)号：US12070604B2

公开(公告)日：2024-08-27

申请号：US17450308

申请日：2021-10-08

Applicant: Galvani Bioelectronics Limited

Inventor： Brian Pepin ,  Shiv Sabesan

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/375

CPC classification number: A61N1/36139 ,  A61N1/0534 ,  A61N1/36007 ,  A61N1/36031 ,  A61N1/36067 ,  A61N1/36135 ,  A61N1/3614 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36062 ,  A61N1/36064 ,  A61N1/36071 ,  A61N1/36085 ,  A61N1/36096 ,  A61N1/3752

Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.