公开(公告)号：US20210040570A1

公开(公告)日：2021-02-11

申请号：US16996727

申请日：2020-08-18

Applicant: GEN-PROBE INCORPORATED

Inventor： Jeffrey M. LINNEN ,  Reinhold B. POLLNER

IPC: C12Q1/70 ,  C12Q1/6818 ,  C12Q1/6816

Abstract: Compositions for detecting flavivirus nucleic acids are for detecting West Nile virus nucleic acids in the 3′ non-coding region. The compositions can include oligonucleotides including nucleotide sequences that are substantially complementary to a West Nile virus target nucleic acid. The compositions can also include a detectable moiety.

公开(公告)号：US20180195136A1

公开(公告)日：2018-07-12

申请号：US15879921

申请日：2018-01-25

Applicant: GEN-PROBE INCORPORATED

Inventor： Jeffrey M. LINNEN ,  Daniel P. KOLK ,  Janel M. DOCKTER ,  Damon K. GETMAN ,  Tadashi YOSHIMURA ,  Martha K. HO-SING-LOY ,  Reinhold B. POLLNER ,  Leslie A. STRINGFELLOW

IPC: C12Q1/70

CPC classification number: C12Q1/706 ,  C12Q1/703

Abstract: Compositions, methods and kits for detecting viral nucleic acids. Targets that can be detected in accordance with the invention include HBV and/or HIV-1 and/or HCV nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers that facilitate detection of very low levels of HBV nucleic acids.

公开(公告)号：US20210010093A1

公开(公告)日：2021-01-14

申请号：US17032310

申请日：2020-09-25

Applicant: GEN-PROBE INCORPORATED

Inventor： Kui GAO ,  Jeffrey M. LINNEN

IPC: C12Q1/70

Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

公开(公告)号：US20180135140A1

公开(公告)日：2018-05-17

申请号：US15618834

申请日：2017-06-09

Applicant: GEN-PROBE INCORPORATED

Inventor： Kui GAO ,  Jeffrey M. LINNEN

IPC: C12Q1/70

Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

公开(公告)号：US20160168651A1

公开(公告)日：2016-06-16

申请号：US15054313

申请日：2016-02-26

Applicant: GEN-PROBE INCORPORATED

Inventor： James M. CARRICK ,  Jeffrey M. LINNEN

IPC: C12Q1/70

CPC classification number: C12Q1/701 ,  C12Q1/702 ,  Y02A50/51

Abstract: Compositions, methods and kits for detecting Chikungunya viral nucleic acids. Particularly described are methods for detecting very low levels of the viral nucleic acids using nucleic acid amplification.

Abstract translation: 用于检测基孔肯雅病毒核酸的组合物，方法和试剂盒。 特别描述的是使用核酸扩增检测非常低水平的病毒核酸的方法。

公开(公告)号：US20140322702A1

公开(公告)日：2014-10-30

申请号：US14273835

申请日：2014-05-09

Applicant: Gen-Probe Incorporated

Inventor： Jeffrey M. LINNEN ,  Reinhold B. POLLNER

IPC: C12Q1/70

CPC classification number: C12Q1/701 ,  C12Q1/6816 ,  C12Q1/6818

Abstract: Methods for detecting flavivirus nucleic acids. Particularly described are methods for detecting West Nile virus nucleic acids in the 3′ non-coding region.

Abstract translation: 检测黄病毒核酸的方法。 特别描述了用于检测3'非编码区中的西尼罗河病毒核酸的方法。

公开(公告)号：US20240011109A1

公开(公告)日：2024-01-11

申请号：US18458047

申请日：2023-08-29

Applicant: Gen-Probe Incorporated

Inventor： Kui GAO ,  Jeffrey M. LINNEN

IPC: C12Q1/70

CPC classification number: C12Q1/701 ,  C12Q2600/16 ,  C12Q2600/158

Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

公开(公告)号：US20220145408A1

公开(公告)日：2022-05-12

申请号：US17580425

申请日：2022-01-20

Applicant: GEN-PROBE INCORPORATED

Inventor： Kui GAO ,  Jeffrey M. LINNEN ,  Kurt C. NORTON ,  Patricia C. GORDON ,  Dat DO ,  Tan N. LE

IPC: C12Q1/70

Abstract: Nucleic acid oligomers specific for human parvovirus genomic DNA. An assay for amplifying and detecting human parvovirus genotypes 1, 2 and 3 nucleic acid in biological specimens. Compositions for amplifying and detecting the presence of human parvovirus genotypes 1, 2 and 3 genomic DNA in human biological specimens.

公开(公告)号：US20210404019A1

公开(公告)日：2021-12-30

申请号：US17475625

申请日：2021-09-15

Applicant: Gen-Probe Incorporated

Inventor： Jijumon CHELLISERRY ,  Kui GAO ,  Jeffrey M. LINNEN

IPC: C12Q1/6893 ,  C12N1/06 ,  G01N33/48 ,  C12Q1/6806

Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.

公开(公告)号：US20210324487A1

公开(公告)日：2021-10-21

申请号：US17356402

申请日：2021-06-23

Applicant: Gen-Probe Incorporated

Inventor： James M. CARRICK ,  Jeffrey M. LINNEN

IPC: C12Q1/70

Abstract: Compositions, methods and kits for detecting Chikungunya virus (CHIKV) nucleic acids are for detecting very low levels of the viral nucleic acids using nucleic acid amplification. The kit includes a first primer up to 100 bases long and includes a target-complementary 3′ terminal sequence of 15-48 contiguous bases. The first primer optionally may include a first primer 5′ sequence (i.e., an upstream sequence) that is not complementary to CHIKV nucleic acids.