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公开(公告)号：US12235040B2
公开(公告)日：2025-02-25
申请号：US18238845
申请日：2023-08-28
Applicant: GEN-PROBE INCORPORATED
Inventor： Reza Bashar
Abstract: A method and apparatus for freezing a liquid droplet includes dispensing, by a liquid dispenser, a droplet of liquid into a fluid chamber containing a freezing fluid. The droplet of liquid is allowed to dwell in the freezing fluid for at least a predetermined dwell time so that the droplet of liquid freezes to a frozen droplet. The method and apparatus further includes injecting, by a gas injector, a stream of gas transversely to a surface of the freezing fluid at about where the frozen droplet is located along the surface of the freezing fluid contained in the fluid chamber so that the frozen droplet sinks in the freezing fluid.
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公开(公告)号：US12210031B2
公开(公告)日：2025-01-28
申请号：US18489478
申请日：2023-10-18
Applicant: GEN-PROBE INCORPORATED
Inventor： Rolf Silbert , HongRan Peng , David Aaron Buse , David H. Combs
Abstract: A receptacle-supporting puck includes spring-biased fingers arranged about a vertical axis, each finger having a contact surface to contact a receptacle seated in the puck. A supporting disc of the puck includes a disc sidewall projecting from a base and defining a pocket for seating a receptacle, first cavities in the base extending toward the vertical axis, and a puck passageway extending through opposed portions of the disc sidewall transversely to and offset from the vertical axis. Each finger is rotatably coupled to the supporting disc at a corresponding first cavity. A synchronization disc is positioned in the pocket, and each of the fingers is coupled to the synchronization disc such that the contact surfaces of the fingers move synchronously toward and away from the vertical axis. A retaining ring couples the fingers, the supporting disc, and the synchronization disc together.
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公开(公告)号：US12210030B2
公开(公告)日：2025-01-28
申请号：US18429318
申请日：2024-01-31
Applicant: Gen-Probe Incorporated
Inventor： Rolf Silbert , HongRan Peng , David Aaron Buse , David H. Combs
Abstract: A method of delivering a receptacle to an instrument includes the steps of supporting a receptacle containing a fluid on a carrier, transporting the carrier supporting the receptacle on a conveyor extending adjacent to each of a plurality of instruments, transferring the receptacle from the carrier to a puck supported on a carriage when the carriage is positioned at a first location, moving the carriage with the receptacle seated in the puck from the first location to a second location within an instrument of the plurality of instruments, and drawing at least a portion of the fluid from the receptacle seated in the puck into a tip associated with a fluid extraction device of the instrument when the carriage is positioned at the second location.
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公开(公告)号：US20250019775A1
公开(公告)日：2025-01-16
申请号：US18900574
申请日：2024-09-27
Applicant: GEN-PROBE INCORPORATED
Inventor： Barbara L. EATON , Benjamin GROBARCZYK , Samira BARHDADI
IPC: C12Q1/689 , C12Q1/6816
Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers and detection probes, for detection of Bordetella pertussis and Bordetella parapertussis nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
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公开(公告)号：US12195793B2
公开(公告)日：2025-01-14
申请号：US18733583
申请日：2024-06-04
Applicant: Gen-Probe Incorporated
Inventor： Sangeetha Vijaysri Nair , Xianqun Wang
IPC: G06F30/20 , C12Q1/6865 , G16B20/00 , G16B40/00 , C12Q1/70
Abstract: Presented are methods, systems, and software products useful for determining the concentration of an analyte in a fluid specimen used to produce a dried sample, where the dried sample serves as a source of the analyte in a detection and quantification procedure. Particularly illustrated is the use of dried blood spots for quantifying a polynucleotide analyte.
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Patent Agency Ranking
公开(公告)号：US12194468B2
公开(公告)日：2025-01-14
申请号：US18061995
申请日：2022-12-05
Applicant: GEN-PROBE INCORPORATED
Inventor： Christopher B. Davis , Norbert D. Hagen , James T. Tuggle
IPC: B01L3/00 , B01L9/00 , B03C1/033 , B03C1/12 , B03C1/14 , B03C1/28 , B25J11/00 , B65B3/04 , C12N15/10 , G01N35/00
Abstract: A method for performing a magnetic separation procedure that includes transporting a receptacle containing a fluid medium to a first location of a system, where the fluid medium contains both a sample material and a suspension of magnetically-responsive solid supports. At the first location, the fluid medium is exposed to a first magnetic field for a first dwell period, thereby isolating the solid supports within the receptacle, where no portion of the fluid medium is removed from the receptacle at the first location. The receptacle is then transported from the first location to a second location of the system, where the fluid medium is exposed to a second magnetic field for a second dwell period. Following the second dwell period, at least a portion of the fluid medium is removed from the receptacle. A suspension fluid is then dispensed into the receptacle, and the contents of the receptacle are agitated to suspend the solid supports within the suspension fluid.
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公开(公告)号：US20240426857A1
公开(公告)日：2024-12-26
申请号：US18830349
申请日：2024-09-10
Applicant: Gen-Probe Incorporated
Inventor： Rolf SILBERT , HongRan PENG
Abstract: A jig assembly for connecting first and second consoles with predefined relative positioning includes first and second positioning pins attached or attachable to the first console and a positioning connection bracket attached or attachable to the second console and including a longitudinal span and first and second transverse legs including first and second pin recesses at respective free ends thereof. The first and second pin recesses receive the first and second positioning pins, respectively, when the first and second consoles are moved laterally toward each other. The first and second transverse legs may be attached to the first console with a first and second leg attachment brackets, respectively. The first and second positing pins and the first and second leg attachment brackets may be fixed with respect to the first console by attachment to a mounting rail that is fixed to the first console.
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公开(公告)号：US12175322B2
公开(公告)日：2024-12-24
申请号：US18331027
申请日：2023-06-07
Applicant: GEN-PROBE INCORPORATED
Inventor： David Opalsky
Abstract: A method of reading machine-readable marks on a movable support and object of a sample instrument. The method includes capturing a first image of the moveable support as the moveable support moves from a first position to a second position using an image capture device; determining whether a first fiducial machine-readable mark on the moveable support is in the first image; determining, when the first fiducial machine-readable mark is in the first image, whether a first machine-readable mark on a first object coupled to the moveable support is in the first image at a predetermined position relative to the first fiducial machine-readable mark; and associating information decoded from the first machine-readable mark on the first object with a first location on the moveable support associated with the first fiducial machine-readable mark.
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公开(公告)号：US20240393358A1
公开(公告)日：2024-11-28
申请号：US18797273
申请日：2024-08-07
Applicant: Gen-Probe Incorporated
Inventor： David A. BUSE , Norbert D. HAGEN , David OPALSKY
IPC: G01N35/04 , B65G29/00 , B65G47/84 , G01F23/263
Abstract: A mechanism for holding and moving a plurality of containers includes a carousel configured to be rotatable about a vertically-oriented axis of rotation, and the carousel includes a plurality of container-holding pockets arranged circumferentially around an outer periphery of the carousel. Each container includes a vertically-oriented groove formed on each of opposed sides of the container. Each container-holding pocket is open at the outer periphery of the carousel to permit a container to be withdrawn out of the pocket in a radial direction with respect to the axis of rotation, and each container-holding pocket includes retention clips configured to engage the grooves formed on the container to removably retain the container within the container pocket.
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公开(公告)号：US20240359177A1
公开(公告)日：2024-10-31
申请号：US18763917
申请日：2024-07-03
Applicant: GEN-PROBE INCORPORATED
Inventor： Yann MARCY , Quentin LE MASNE , Kevin MARQ
IPC: B01L3/00 , B01L9/00 , C12Q1/6844
CPC classification number: B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L9/527 , C12Q1/6844 , B01L2200/027 , B01L2200/16 , B01L2300/0654 , B01L2300/0819 , B01L2300/0848 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2400/0478 , B01L2400/0487 , B01L2400/0622 , B01L2400/0638 , B01L2400/0644 , B01L2400/065 , B01L2400/0655
Abstract: A cam-driven actuator for actuating valves of a microfluidic cartridge includes a plunger associated with each valve, a plunger guide plate having a plunger guide hole for each plunger, an actuating ball associated with each plunger and in contact with the associated plunger, a ball guide plate having a ball guide hole for each actuating ball; and a cam including a first surface and a cam recess. Each actuating ball is in contact with the cam and the cam is movable with respect to each actuating ball between (i) an engaged position at which the actuating ball is in contact with the first surface and the associated plunger is in an engaged position to close the associated valve, and (ii) a disengaged position at which the actuating ball is disposed within the cam recess and the associated plunger is in a disengaged position to open the associated valve.
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