公开(公告)号：US20230416825A1

公开(公告)日：2023-12-28

申请号：US18192505

申请日：2023-03-29

Applicant: Genentech, Inc.

Inventor： Amy Dressen ,  David B. Iaea ,  Moulay Hicham Alaoui Ismaili ,  Janet K. Jackman ,  Robert A. Lazarus ,  Kelly Michele Loyet ,  Henry R. Maun ,  Brian Louis Yaspan ,  Tangsheng Yi ,  Joseph R. Arron ,  Hilda Y Hernandez-Barry

IPC: C12Q1/6883 ,  C07K16/40 ,  C07K14/81 ,  G01N33/68 ,  C12N9/64

CPC classification number: C12Q1/6883 ,  C07K16/40 ,  C07K14/8135 ,  G01N33/6893 ,  C12N9/6445 ,  C12Q2600/106 ,  C12Q2600/156 ,  A61K38/00

Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Sydrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.