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公开(公告)号：US20230416825A1
公开(公告)日：2023-12-28
申请号：US18192505
申请日：2023-03-29
申请人： Genentech, Inc.
发明人： Amy Dressen , David B. Iaea , Moulay Hicham Alaoui Ismaili , Janet K. Jackman , Robert A. Lazarus , Kelly Michele Loyet , Henry R. Maun , Brian Louis Yaspan , Tangsheng Yi , Joseph R. Arron , Hilda Y Hernandez-Barry
IPC分类号： C12Q1/6883 , C07K16/40 , C07K14/81 , G01N33/68 , C12N9/64
CPC分类号： C12Q1/6883 , C07K16/40 , C07K14/8135 , G01N33/6893 , C12N9/6445 , C12Q2600/106 , C12Q2600/156 , A61K38/00
摘要： Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Sydrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.
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2.发明申请METHODS OF PROGNOSING, DIAGNOSING AND TREATING IDIOPATHIC PULMONARY FIBROSIS 审中-公开预防，诊断和治疗特发性肺动脉硬化症的方法公开(公告)号：US20160230226A1
公开(公告)日：2016-08-11
申请号：US14493649
申请日：2014-09-23
申请人： GENENTECH, INC.
发明人： Alexander R. Abbas , Joseph R. Arron , Sanjay Chandriani , Guiquan Jia , Nicholas J.I. Lewin-Koh , Daryle DePianto
CPC分类号： C12Q1/6883 , A61K38/00 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K16/244 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C12Q2600/118 , C12Q2600/158 , G01N33/6893 , G01N2333/521 , G01N2333/775 , G01N2333/96494 , G01N2800/12 , G01N2800/52
摘要： Compositions, kits and methods for assessing the prognosis of idiopathic pulmonary fibrosis in patients are provided. In addition, compositions, kits and methods for diagnosing subtypes of idiopathic pulmonary fibrosis are provided. Also provided are methods for treating idiopathic pulmonary fibrosis.
摘要翻译： 提供了用于评估患者特发性肺纤维化预后的组合物，试剂盒和方法。 此外，提供了用于诊断特发性肺纤维化亚型的组合物，试剂盒和方法。 还提供了治疗特发性肺纤维化的方法。
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公开(公告)号：US20240279322A1
公开(公告)日：2024-08-22
申请号：US18420510
申请日：2024-01-23
申请人： Genentech, Inc.
发明人： Wei-Ching Liang , Joseph R. Arron , Daryle DePianto , Wendy Green Halpern , WeiYu Lin , Patrick J. Lupardus , Thirumalai Rajan Ramalingam , Dhaya Seshasayee , Tianhe Sun , Tulika Tyagi , Jia Wu , Yan Wu , Jian Ping Yin
IPC分类号： C07K16/22 , A61K39/00 , A61K39/395 , A61P11/00 , C07K16/46
CPC分类号： C07K16/22 , A61P11/00 , C07K16/464 , A61K39/39533 , A61K39/39566 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.
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公开(公告)号：US09995755B2
公开(公告)日：2018-06-12
申请号：US14021947
申请日：2013-09-09
申请人： Genentech, Inc.
发明人： Joseph R. Arron , Richard W. Erickson , Michelle Freemer , Meredith Hazen , Guiquan Jia , John G. Matthews , Wendy Putnam , Heleen Scheerens , Yanan Zheng
IPC分类号： A61K39/00 , A61K45/00 , G01N33/68 , C07K16/28 , A61K39/395 , C07K16/18 , A61K31/522 , A61K31/573 , A61K45/06
CPC分类号： G01N33/6884 , A61K31/522 , A61K31/573 , A61K39/3955 , A61K39/39566 , A61K45/06 , C07K16/18 , C07K16/28 , G01N33/6887 , G01N33/6893 , G01N2333/475 , G01N2800/122 , G01N2800/52
摘要： Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
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公开(公告)号：US11226341B2
公开(公告)日：2022-01-18
申请号：US15992115
申请日：2018-05-29
申请人： GENENTECH, INC.
发明人： Joseph R. Arron , Richard W. Erickson , Michelle Freemer , Meredith Hazen , Guiquan Jia , John G. Matthews , Wendy Putnam , Heleen Scheerens , Yanan Zheng
IPC分类号： A61K39/395 , G01N33/68 , C07K16/28 , C07K16/24 , C07K16/18 , A61K31/522 , A61K31/573 , A61K45/06
摘要： Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
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公开(公告)号：US09684000B2
公开(公告)日：2017-06-20
申请号：US14021698
申请日：2013-09-09
申请人： Genentech, Inc.
发明人： Joseph R. Arron , Richard W. Erickson , Michelle Freemer , Meredith Hazen , Guiquan Jia , John G. Matthews , Wendy Putnam , Heleen Scheerens , Yanan Zheng
IPC分类号： C07K16/00 , G01N33/68 , C07K16/28 , A61K39/395 , C07K16/18 , A61K31/522 , A61K31/573 , A61K45/06
CPC分类号： G01N33/6884 , A61K31/522 , A61K31/573 , A61K39/3955 , A61K39/39566 , A61K45/06 , C07K16/18 , C07K16/28 , G01N33/6887 , G01N33/6893 , G01N2333/475 , G01N2800/122 , G01N2800/52
摘要： Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
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公开(公告)号：US20140044645A1
公开(公告)日：2014-02-13
申请号：US14021698
申请日：2013-09-09
申请人： Genentech, Inc.
发明人： Joseph R. Arron , Richard W. Erickson , Michelle Freemer , Meredith Hazen , Guiquan Jia , John G. Matthews , Wendy Putnam , Heleen Scheerens , Yanan Zheng
IPC分类号： G01N33/68 , A61K39/395 , C07K16/18
CPC分类号： G01N33/6884 , A61K31/522 , A61K31/573 , A61K39/3955 , A61K39/39566 , A61K45/06 , C07K16/18 , C07K16/28 , G01N33/6887 , G01N33/6893 , G01N2333/475 , G01N2800/122 , G01N2800/52
摘要： Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
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公开(公告)号：US11919948B2
公开(公告)日：2024-03-05
申请号：US17205663
申请日：2021-03-18
申请人： Genentech, Inc.
发明人： Wei-Ching Liang , Joseph R. Arron , Daryle Depianto , Wendy Green Halpern , WeiYu Lin , Patrick J. Lupardus , Thirumalai Rajan Ramalingam , Dhaya Seshasayee , Tianhe Sun , Tulika Tyagi , Jia Wu , Yan Wu , Jian Ping Yin
IPC分类号： C07K16/22 , A61K39/00 , A61K39/395 , A61P11/00 , C07K16/46
CPC分类号： C07K16/22 , A61P11/00 , C07K16/464 , A61K39/39533 , A61K39/39566 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.
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公开(公告)号：US20190120854A1
公开(公告)日：2019-04-25
申请号：US15992115
申请日：2018-05-29
申请人： GENENTECH, INC.
发明人： Joseph R. Arron , Richard W. Erickson , Michelle Freemer , Meredith Hazen , Guiquan Jia , John G. Matthews , Wendy Putnam , Heleen Scheerens , Yanan Zheng
IPC分类号： G01N33/68 , C07K16/24 , A61K31/573 , A61K31/522 , A61K45/06 , A61K39/395 , C07K16/28 , C07K16/18
摘要： Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
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公开(公告)号：US20190078160A1
公开(公告)日：2019-03-14
申请号：US15958696
申请日：2018-04-20
申请人： Genentech, Inc.
发明人： Amy Dressen , David B. Iaea , Moulay Hicham Alaoui Ismaili , Janet K. Jackman , Robert A. Lazarus , Kelly Loyet , Henry R. Maun , Brian L. Yaspan , Tangsheng Yi , Joseph R. Arron , Hilda Y. Hernandez-Barry
IPC分类号： C12Q1/6883
摘要： Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Syndrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.
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