公开(公告)号：US20240368306A1

公开(公告)日：2024-11-07

申请号：US18439879

申请日：2024-02-13

Applicant: Genentech, Inc.

Inventor： Xiaocheng CHEN ,  Mark Dennis ,  Janet Jackman ,  James T. Koerber ,  Mason Lu ,  Henry R. Maun ,  Kathila Rajapaksa ,  Saroja Ramanujan ,  Tracy Staton ,  Lawren Wu ,  Tangsheng Yi

IPC: C07K16/40 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  C07K16/24

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US10562946B2

公开(公告)日：2020-02-18

申请号：US15320736

申请日：2015-06-19

Applicant: Genentech, Inc.

Inventor： Robert A. Lazarus ,  Henry R. Maun

IPC: C07K14/44 ,  C12N15/10 ,  A61K38/00

Abstract: Provided are novel, non-naturally occurring chagasin scaffold proteins derived from chagasin or chagasin-like protease inhibitor proteins. Also provided are libraries of non-naturally occurring chagasin scaffold proteins and methods of using such libraries to generate non-naturally occurring chagasin scaffold proteins that specifically bind to a target ligand. The present invention further provides methods of using non-naturally occurring chagasin protein scaffold that bind to a target ligand, including diagnostic and therapeutic compositions and methods. The invention also provides novel non-naturally occurring chagasin scaffold proteins that specifically bind low density lipoprotein receptor-related protein 6 (LRP6) and novel non-naturally occurring chagasin scaffold proteins that specifically bind vascular endothelial growth factor (VEGF).

公开(公告)号：US20230416825A1

公开(公告)日：2023-12-28

申请号：US18192505

申请日：2023-03-29

Applicant: Genentech, Inc.

Inventor： Amy Dressen ,  David B. Iaea ,  Moulay Hicham Alaoui Ismaili ,  Janet K. Jackman ,  Robert A. Lazarus ,  Kelly Michele Loyet ,  Henry R. Maun ,  Brian Louis Yaspan ,  Tangsheng Yi ,  Joseph R. Arron ,  Hilda Y Hernandez-Barry

IPC: C12Q1/6883 ,  C07K16/40 ,  C07K14/81 ,  G01N33/68 ,  C12N9/64

CPC classification number: C12Q1/6883 ,  C07K16/40 ,  C07K14/8135 ,  G01N33/6893 ,  C12N9/6445 ,  C12Q2600/106 ,  C12Q2600/156 ,  A61K38/00

Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Sydrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.

公开(公告)号：US11939396B2

公开(公告)日：2024-03-26

申请号：US16916822

申请日：2020-06-30

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Janet Jackman ,  James T. Koerber ,  Mason Lu ,  Henry R. Maun ,  Kathila Rajapaksa ,  Saroja Ramanujan ,  Tracy Staton ,  Lawren Wu ,  Tangsheng Yi

IPC: C07K16/40 ,  A61K39/395 ,  C07K16/24 ,  A61K39/00 ,  A61K45/06 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K39/39591 ,  C07K16/244 ,  C12Y304/21059 ,  A61K2039/505 ,  A61K45/06 ,  A61K47/10 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US10738131B2

公开(公告)日：2020-08-11

申请号：US15893238

申请日：2018-02-09

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Janet Jackman ,  James T. Koerber ,  Mason Lu ,  Henry R. Maun ,  Kathila Rajapaksa ,  Saroja Ramanujan ,  Tracy Staton ,  Lawren Wu ,  Tangsheng Yi

IPC: C07K16/40 ,  A61K39/395 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10 ,  A61K45/06 ,  C07K16/24 ,  A61K39/00

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US10752703B2

公开(公告)日：2020-08-25

申请号：US16544421

申请日：2019-08-19

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Janet Jackman ,  James T. Koerber ,  Mason Lu ,  Henry R. Maun ,  Kathila Rajapaksa ,  Saroja Ramanujan ,  Tracy Staton ,  Lawren Wu ,  Tangsheng Yi

IPC: C07K16/40 ,  A61K39/395 ,  A61K39/00 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10 ,  A61K45/06 ,  C07K16/24

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US20190078160A1

公开(公告)日：2019-03-14

申请号：US15958696

申请日：2018-04-20

Applicant: Genentech, Inc.

Inventor： Amy Dressen ,  David B. Iaea ,  Moulay Hicham Alaoui Ismaili ,  Janet K. Jackman ,  Robert A. Lazarus ,  Kelly Loyet ,  Henry R. Maun ,  Brian L. Yaspan ,  Tangsheng Yi ,  Joseph R. Arron ,  Hilda Y. Hernandez-Barry

IPC: C12Q1/6883

Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Syndrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.