公开(公告)号：US20150044205A1

公开(公告)日：2015-02-12

申请号：US14456268

申请日：2014-08-11

Applicant: Genentech,Inc.

Inventor： Brian Yaspan ,  Robert Royal Graham ,  Amy Dressen ,  Zhengrong Li ,  Erich Strauss ,  Teodorica Bugawan

IPC: C12Q1/68 ,  C07K16/40

CPC classification number: C12Q1/6883 ,  A61K2039/505 ,  C07K16/40 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.

Abstract translation: 本发明提供用因子D抑制剂（例如，抗因子D抗体或其抗原结合片段）治疗各种退行性疾病（例如AMD）的方法和组合物。 还提供了选择或鉴定患者用因子D抑制剂治疗的方法。 方法包括使用预后和/或预测生物标志物。

公开(公告)号：US20230416825A1

公开(公告)日：2023-12-28

申请号：US18192505

申请日：2023-03-29

Applicant: Genentech, Inc.

Inventor： Amy Dressen ,  David B. Iaea ,  Moulay Hicham Alaoui Ismaili ,  Janet K. Jackman ,  Robert A. Lazarus ,  Kelly Michele Loyet ,  Henry R. Maun ,  Brian Louis Yaspan ,  Tangsheng Yi ,  Joseph R. Arron ,  Hilda Y Hernandez-Barry

IPC: C12Q1/6883 ,  C07K16/40 ,  C07K14/81 ,  G01N33/68 ,  C12N9/64

CPC classification number: C12Q1/6883 ,  C07K16/40 ,  C07K14/8135 ,  G01N33/6893 ,  C12N9/6445 ,  C12Q2600/106 ,  C12Q2600/156 ,  A61K38/00

Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Sydrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.

公开(公告)号：US20210207219A1

公开(公告)日：2021-07-08

申请号：US17147061

申请日：2021-01-12

Applicant: Genentech, Inc.

Inventor： Brian Yaspan ,  Robert Royal Graham ,  Amy Dressen ,  Zhengrong Li ,  Erich Strauss ,  Teodorica Bugawan

IPC: C12Q1/6883

Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.

公开(公告)号：US11708608B2

公开(公告)日：2023-07-25

申请号：US15525460

申请日：2015-11-10

Applicant: Genentech, Inc.

Inventor： Rajita Khosla ,  Vladimir Ramirez-Carrozzi ,  Tracy Staton ,  Brian Yaspan ,  Joseph Arron ,  David Choy ,  Amy Dressen

IPC: C12Q1/68 ,  C12Q1/6883 ,  G01N33/68

CPC classification number: C12Q1/6883 ,  G01N33/6869 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  Y02A50/30

Abstract: The invention relates to methods of treating a patient suffering from an IL-33-mediated disorder, such as asthma, comprising administering to the patient an IL-33 axis binding antagonist based on the genotype of the /L1RL1gene, the genotype of a polymorphism in genomic vicinity to the IL-33 gene, the expression level of periostin or the expression level of soluble ST2. The invention further relates to methods of determining whether a patient is at increased risk of an IL-33-mediated disorder, as well as methods of determining whether a patient suffering from such a disorder is likely to respond to a treatment comprising an IL-33 axis binding antagonist, based on the genotype of the /L1RL1gene the genotype of a polymorphism in genomic vicinity to the IL-33 gene, the expression level of periostin or the expression level of soluble ST2.

公开(公告)号：US10947591B2

公开(公告)日：2021-03-16

申请号：US16105952

申请日：2018-08-20

Applicant: GENENTECH, INC.

Inventor： Brian Yaspan ,  Robert Royal Graham ,  Amy Dressen ,  Zhengrong Li ,  Erich Strauss ,  Teodorica Bugawan

IPC: C12Q1/6883 ,  C07K16/40 ,  A61K39/00

Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.

公开(公告)号：US20190078160A1

公开(公告)日：2019-03-14

申请号：US15958696

申请日：2018-04-20

Applicant: Genentech, Inc.

Inventor： Amy Dressen ,  David B. Iaea ,  Moulay Hicham Alaoui Ismaili ,  Janet K. Jackman ,  Robert A. Lazarus ,  Kelly Loyet ,  Henry R. Maun ,  Brian L. Yaspan ,  Tangsheng Yi ,  Joseph R. Arron ,  Hilda Y. Hernandez-Barry

IPC: C12Q1/6883

Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Syndrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.

公开(公告)号：US10093978B2

公开(公告)日：2018-10-09

申请号：US14456268

申请日：2014-08-11

Applicant: Genentech, Inc.

Inventor： Brian Yaspan ,  Robert Royal Graham ,  Amy Dressen ,  Zhengrong Li ,  Erich Strauss ,  Teodorica Bugawan

IPC: C12Q1/6883 ,  C07K16/40 ,  A61K39/00

Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.