公开(公告)号：US20200331968A1

公开(公告)日：2020-10-22

申请号：US16816969

申请日：2020-03-12

Applicant: Genentech, Inc.

Inventor： Emily J. HANAN ,  Georgette CASTANEDO ,  Marie Gabrielle BRAUN ,  Keira GARLAND ,  Peter Andrew SMITH ,  Richard PASTOR ,  Paul GIBBONS ,  Yunxing CHENG ,  Guosheng WU ,  Yuhong FU ,  Po-Wai YUEN

IPC: C07K11/02

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20240391930A1

公开(公告)日：2024-11-28

申请号：US18670537

申请日：2024-05-21

Applicant: GENENTECH, INC. ,  CONVELO THERAPEUTICS, INC.

Inventor： Marie-Gabrielle BRAUN ,  Georgette CASTANEDO ,  William VERNIER ,  Matthew VOLGRAF ,  Michael SIU ,  James Guy BREITENBUCHER

IPC: C07D495/10 ,  A61K31/4155 ,  A61K31/4196 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506

Abstract: The subject matter described herein is directed to myelin-promoting compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for the treatment of disorders, such as myelin-related disorders.

公开(公告)号：US20240398781A1

公开(公告)日：2024-12-05

申请号：US18670608

申请日：2024-05-21

Applicant: GENENTECH, INC. ,  CONVELO THERAPEUTICS, INC.

Inventor： Marie-Gabrielle BRAUN ,  Georgette CASTANEDO ,  William VERNIER ,  Matthew VOLGRAF ,  James Guy BREITENBUCHER ,  Brad LANG

IPC: A61K31/4545 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/454 ,  C07D495/10

Abstract: The subject matter described herein is directed to myelin-promoting compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for the treatment of disorders, such as myelin-related disorders.