公开(公告)号：US20160244456A1

公开(公告)日：2016-08-25

申请号：US15144422

申请日：2016-05-02

Applicant: Genentech, Inc.

Inventor： Jeffrey BLANEY ,  Paul A. GIBBONS ,  Emily HANAN ,  Joseph P. LYSSIKATOS ,  Steven R. MAGNUSON ,  Richard PASTOR ,  Thomas E. RAWSON ,  Aihe ZHOU ,  Bing-Yan ZHU

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The invention provides JAK kinase inhibitors of Formula Ia, enantiomers, diasteriomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R7 and Z are defined herein, a pharmaceutical composition that includes a compound of Formula Ia and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a JAK kinase activity in a patient.

Abstract translation: 本发明提供了式Ia的JAK激酶抑制剂，其对映体，非对映异构体或其药学上可接受的盐，其中R1，R2，R7和Z在本文中定义，药物组合物包括式Ia化合物和药学上可接受的载体，佐剂或载体 以及对患者中JAK激酶活性的抑制作出反应的疾病或病症的严重程度的治疗或减轻的方法。

公开(公告)号：US20200331968A1

公开(公告)日：2020-10-22

申请号：US16816969

申请日：2020-03-12

Applicant: Genentech, Inc.

Inventor： Emily J. HANAN ,  Georgette CASTANEDO ,  Marie Gabrielle BRAUN ,  Keira GARLAND ,  Peter Andrew SMITH ,  Richard PASTOR ,  Paul GIBBONS ,  Yunxing CHENG ,  Guosheng WU ,  Yuhong FU ,  Po-Wai YUEN

IPC: C07K11/02

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.