公开(公告)号：US20200024309A1

公开(公告)日：2020-01-23

申请号：US16539947

申请日：2019-08-13

Applicant: RQx Pharmaceuticals, Inc. ,  Genentech, Inc.

Inventor： Peter Andrew SMITH ,  Tucker Curran ROBERTS ,  Robert I. HIGUCHI ,  Prasuna PARASELLI ,  Michael F. T. KOEHLER ,  Jacob Bradley SCHWARZ ,  James John CRAWFORD ,  Cuong Q. LY ,  Emily J. HANAN ,  Huiyong HU ,  Yongsheng CHEN ,  Zhiyong YU ,  Paul Colin Michael WINSHIP ,  Calum McCleod ,  Toby Blench

IPC: C07K5/11 ,  A61P31/04 ,  A61K9/00 ,  A61K45/06 ,  A61K38/07 ,  C07K5/107 ,  C07K5/083 ,  C07K7/06 ,  A61K38/08 ,  C07K5/097 ,  A61K38/06

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20210198316A9

公开(公告)日：2021-07-01

申请号：US16539947

申请日：2019-08-13

Applicant: RQx Pharmaceuticals, Inc. ,  Genentech, Inc.

Inventor： Peter Andrew SMITH ,  Tucker Curran ROBERTS ,  Robert I. HIGUCHI ,  Prasuna PARASELLI ,  Michael F. T. KOEHLER ,  Jacob Bradley SCHWARZ ,  James John CRAWFORD ,  Cuong Q. LY ,  Emily J. HANAN ,  Huiyong HU ,  Yongsheng CHEN ,  Zhiyong YU ,  Paul Colin Michael WINSHIP ,  Calum McCleod ,  Toby Blench

IPC: C07K5/11 ,  A61P31/04 ,  A61K9/00 ,  A61K45/06 ,  A61K38/07 ,  C07K5/107 ,  C07K5/083 ,  C07K7/06 ,  A61K38/08 ,  C07K5/097 ,  A61K38/06

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20200239519A1

公开(公告)日：2020-07-30

申请号：US15777509

申请日：2016-11-21

Applicant: RQX PHARMACEUTICALS, INC. ,  GENENTECH, INC.

Inventor： Yongsheng CHEN ,  Peter Andrew SMITH ,  Tucker Curran ROBERTS ,  Robert I. HIGUCHI ,  Prasuna PARASELLI ,  Michael F. T. KOEHLER ,  Jacob Bradley SCHWARZ ,  James John CRAWFORD ,  Cuong Q. LY ,  Huiyong HU ,  Zhiyong YU

IPC: C07K7/06 ,  A61P31/04

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20200331968A1

公开(公告)日：2020-10-22

申请号：US16816969

申请日：2020-03-12

Applicant: Genentech, Inc.

Inventor： Emily J. HANAN ,  Georgette CASTANEDO ,  Marie Gabrielle BRAUN ,  Keira GARLAND ,  Peter Andrew SMITH ,  Richard PASTOR ,  Paul GIBBONS ,  Yunxing CHENG ,  Guosheng WU ,  Yuhong FU ,  Po-Wai YUEN

IPC: C07K11/02

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20180327367A1

公开(公告)日：2018-11-15

申请号：US15777499

申请日：2016-11-21

Applicant: RQX PHARMACEUTICALS, INC. ,  GENENTECH, INC.

Inventor： Yongsheng CHEN ,  Peter Andrew SMITH ,  Tucker Curran ROBERTS ,  Robert I. HIGUCHI ,  Prasuna PARASELLI ,  Michael F. T. KOEHLER ,  Jacob Bradley SCHWARZ ,  James John CRAWFORD ,  Cuong Q. LY ,  Emily J. HANAN ,  Huiyong HU ,  Zhiyong YU

IPC: C07D245/04 ,  C07K5/02 ,  A61K38/08 ,  A61K38/06 ,  A61K31/496 ,  A61K31/546 ,  A61K38/07 ,  C07K5/087 ,  C07K5/103 ,  C07K5/11 ,  C07K5/113 ,  C07K5/117 ,  C07K7/06 ,  C07K7/08 ,  C07K9/00 ,  A61P31/04 ,  A61K9/00

CPC classification number: C07D245/04 ,  A61K9/0014 ,  A61K31/395 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/43 ,  A61K31/431 ,  A61K31/496 ,  A61K31/545 ,  A61K31/546 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K45/06 ,  A61K2300/00 ,  A61P31/04 ,  C07K5/0202 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/1008 ,  C07K5/1013 ,  C07K5/1019 ,  C07K5/1021 ,  C07K5/1024 ,  C07K7/06 ,  C07K7/08 ,  C07K9/008 ,  Y02A50/404 ,  Y02A50/406

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20170088582A1

公开(公告)日：2017-03-30

申请号：US15312614

申请日：2015-05-19

Applicant: RQX PHARMACEUTICALS, INC. ,  GENENTECH, INC.

Inventor： Tucker Curran ROBERTS ,  Peter Andrew SMITH ,  Robert I. HIGUCHI ,  Prasuna PARASELLI ,  Philippe BERGERON ,  Michael F.T. KOEHLER ,  Huiyong HU ,  Jacob Bradley SCHWARZ ,  Cuong LY ,  James CRAWFORD

IPC: C07K5/103 ,  A61K38/07 ,  A61K38/06 ,  C07K7/06 ,  A61K38/08 ,  A61K45/06 ,  C07K5/083

CPC classification number: C07K5/101 ,  A61K31/395 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/43 ,  A61K31/431 ,  A61K31/496 ,  A61K31/545 ,  A61K31/546 ,  A61K38/00 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/12 ,  A61K45/06 ,  C07K5/0202 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/1008 ,  C07K5/1013 ,  C07K5/1019 ,  C07K7/06 ,  C07K7/08 ,  Y02A50/401 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/483 ,  A61K2300/00 ,  A61L2300/00

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.