公开(公告)号：US20240150491A1

公开(公告)日：2024-05-09

申请号：US18389748

申请日：2023-12-19

Applicant: Genentech, Inc.

Inventor： James Thomas KOERBER ,  Wyne Pun LEE ,  Tangsheng YI ,  Juan ZHANG ,  Cary Dean AUSTIN ,  Cecilia P.C. CHIU ,  Joseph Edward CHAVARRIA-SMITH ,  Jawahar SUDHAMSU

IPC: C07K16/40 ,  A61K39/395 ,  A61P17/00

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61P17/00 ,  A61K2039/507

Abstract: The invention provides anti-KLK7 antibodies, anti-KLK5 antibodies, anti-KLK5/KLK7 multispecific antibodies, and methods of using the same.

公开(公告)号：US20240109958A1

公开(公告)日：2024-04-04

申请号：US18537389

申请日：2023-12-12

Applicant: Genentech, Inc.

Inventor： Donald Scott KIRKPATRICK ,  James Thomas KOERBER ,  Christopher Williamson DAVIES

IPC: C07K16/18 ,  C07K16/00 ,  C40B30/04 ,  G01N33/68

CPC classification number: C07K16/18 ,  C07K16/005 ,  C40B30/04 ,  G01N33/6845 ,  C07K2317/20 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622

Abstract: Provided herein are antibodies that bind to a peptide of an N-terminally ubiquitinated polypeptide and methods of screening for such antibodies. Also provided herein are detection and enrichment methods using such antibodies for detecting or enriching a peptide of an N-terminally ubiquitinated polypeptide.

公开(公告)号：US20230192853A1

公开(公告)日：2023-06-22

申请号：US17640499

申请日：2020-09-03

Applicant: GENENTECH, INC. ,  F. Hoffmann-LA Roche AG

Inventor： James Thomas KOERBER ,  Alejandra Beatrice Urpi URRUTIA ,  Simon-Peter WILLIAMS ,  Christopher Williamson DAVIES ,  Shravan Kumar SRIRAMAN ,  Herman Singh GILL ,  James Richard KIEFER, Jr.

IPC: C07K16/28 ,  A61K51/10 ,  G01N33/574

CPC classification number: C07K16/2815 ,  A61K51/1027 ,  A61K51/1093 ,  G01N33/57492 ,  C07K2317/92 ,  C07K2317/569 ,  C07K2317/24 ,  C07K2317/22 ,  C07K2317/74

Abstract: Provided are CD8 binding agents comprising a VHH domain that specifically binds human CD8. Also provided are nucleic acids encoding such CD8 binding agents, vectors comprising such nucleic acids, host cells comprising same, and methods of making such CD8 binding agents. Also provided are CD8 binding agents having the VHH domain conjugated to a detectable label. Provided are methods of using such CD8 binding agents to detect CD8+ T cells, monitor disease progress, and monitor treatment progress in a subject having cancer, autoimmune disease or condition, transplant rejection or graft-versus-host disease.

公开(公告)号：US20240360229A1

公开(公告)日：2024-10-31

申请号：US18416525

申请日：2024-01-18

Applicant: Genentech, Inc.

Inventor： Christoph SPIESS ,  Baomei WANG ,  Ambrose Jon WILLIAMS ,  Cecilia Pui Chi CHIU ,  Michael Andrew DILLON ,  Teemu Tapani JUNTTILA ,  James Thomas KOERBER

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/2866 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73

Abstract: The present invention provides anti-C-C motif chemokine receptor 8 (CCR8) antigen-binding molecules (e.g., bispecific antigen-binding molecules) and compositions thereof. The invention also features polynucleotides, vectors, host cells, methods of production, pharmaceutical compositions, methods of treating a disease or disorder, such as cancer, methods of depleting regulatory T cells, related uses and compositions for use, and kits for use with the one or more methods.

公开(公告)号：US20220099677A1

公开(公告)日：2022-03-31

申请号：US17469533

申请日：2021-09-08

Applicant: GENENTECH, INC.

Inventor： Vinita GUPTA ,  Ann Therese BRADY ,  James Thomas KOERBER ,  Xiangdan WANG ,  Minh Michael Nhu PHAN ,  Yonglian SUN

IPC: G01N33/574

Abstract: The present disclosure provides assays for the detection and/or quantification of membrane-associated proteins, e.g., circulating CD20 (cCD20), incorporating an extracellular vesicle-based calibrator comprising the membrane-associated tumor antigen as well as the use of such assays in the detection and treatment of hyperproliferative disorders.