公开(公告)号：US20230218782A1

公开(公告)日：2023-07-13

申请号：US18056856

申请日：2022-11-18

Applicant: Genentech, Inc.

Inventor： Jan MARIK ,  Joseph P. LYSSIKATOS ,  Simon Peter WILLIAMS

IPC: A61K51/04 ,  C07B59/00 ,  C07D487/04

CPC classification number: A61K51/0459 ,  C07B59/002 ,  C07D487/04 ,  C07B2200/05

Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V):










and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.

公开(公告)号：US20160168261A1

公开(公告)日：2016-06-16

申请号：US14953763

申请日：2015-11-30

Applicant: Genentech, Inc.

Inventor： Mark DENNIS ,  Jan MARIK ,  Paul POLAKIS ,  Bonnee RUBINFELD ,  Simon WILLIAMS

IPC: C07K16/30 ,  A61K51/10 ,  C07K16/40

CPC classification number: C07K16/40 ,  A61K47/6811 ,  A61K47/6871 ,  A61K51/1072 ,  A61K51/1075 ,  A61K51/1093 ,  A61K51/1096 ,  A61K2039/505 ,  C07B59/008 ,  C07B2200/05 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/534 ,  G01N33/57492 ,  G01N33/60 ,  G01N33/6893

Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.

公开(公告)号：US20170121424A1

公开(公告)日：2017-05-04

申请号：US15289485

申请日：2016-10-10

Applicant: Genentech, Inc.

Inventor： Mark DENNIS ,  Jan MARIK ,  Paul POLAKIS ,  Bonnee RUBINFELD ,  Simon WILLIAMS

IPC: C07K16/40 ,  C07B59/00 ,  G01N33/574 ,  G01N33/534 ,  G01N33/60 ,  A61K51/10 ,  C07K16/30

CPC classification number: C07K16/40 ,  A61K47/6811 ,  A61K47/6871 ,  A61K51/1072 ,  A61K51/1075 ,  A61K51/1093 ,  A61K51/1096 ,  A61K2039/505 ,  C07B59/008 ,  C07B2200/05 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/534 ,  G01N33/57492 ,  G01N33/60 ,  G01N33/6893

Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.