公开(公告)号：US20240092887A1

公开(公告)日：2024-03-21

申请号：US18364185

申请日：2023-08-02

Applicant: Genentech, Inc.

Inventor： Gerald R. NAKAMURA ,  Dhaya SESHASAYEE ,  Menno VAN LOOKEREN CAMPAGNE ,  Tiffany WONG ,  Jia WU ,  Hongkang XI ,  Jack BEVERS, III ,  Hiu Nam CHAN ,  Laetitia COMPS-AGRAR ,  Racquel CORPUZ

IPC: C07K16/24 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505

Abstract: The invention provides interleukin-33 (IL-33) antibodies and methods of making and using the same, e.g., for treatment of IL-33 mediated disorders (e.g., ocular disorders such as AMD (e.g., geographic atrophy (GA)).

公开(公告)号：US20210301005A1

公开(公告)日：2021-09-30

申请号：US17205663

申请日：2021-03-18

Applicant: Genentech, Inc.

Inventor： Wei-Ching LIANG ,  Joseph R. ARRON ,  Daryle DEPIANTO ,  Wendy Green HALPERN ,  WeiYu LIN ,  Patrick J. LUPARDUS ,  Thirumalai Rajan RAMALINGAM ,  Dhaya SESHASAYEE ,  Tianhe SUN ,  Tulika TYAGI ,  Jia WU ,  Yan WU ,  Jian Ping YIN

IPC: C07K16/22 ,  A61P11/00 ,  C07K16/46

Abstract: The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.