公开(公告)号：US20190119376A1

公开(公告)日：2019-04-25

申请号：US15994583

申请日：2018-05-31

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN ,  Robert J. JOHNSTON ,  Yan WU ,  Wei-Ching LIANG ,  Patrick LUPARDUS ,  Mahesh YADAV ,  Dhaya SESHASAYEE ,  Meredith HAZEN

IPC: C07K16/28 ,  A61K45/06 ,  A61K38/17 ,  C07K16/30 ,  A61K39/395

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US20190016807A1

公开(公告)日：2019-01-17

申请号：US15881611

申请日：2018-01-26

Applicant: Genentech, Inc.

Inventor： Bryan IRVING ,  Henry CHIU ,  Heather MAECKER ,  Sanjeev MARIATHASAN ,  Sophie M. LEHAR ,  Yan WU ,  Jeanne CHEUNG

IPC: C07K16/28 ,  C07K16/10 ,  C07K16/22 ,  A61K31/7068 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

Abstract: The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

公开(公告)号：US20180186875A1

公开(公告)日：2018-07-05

申请号：US15895741

申请日：2018-02-13

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN ,  Robert J. JOHNSTON ,  Yan WU ,  Wei-Ching LIANG ,  Patrick LUPARDUS ,  Mahesh YADAV ,  Dhaya SESHASAYEE ,  Meredith HAZEN

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K16/30 ,  A61K38/17 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K38/177 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/70 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  Y02A50/466

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US20170107287A1

公开(公告)日：2017-04-20

申请号：US15335278

申请日：2016-10-26

Applicant: Genentech, Inc.

Inventor： Bryan IRVING ,  Henry CHIU ,  Heather MAECKER ,  Sanjeev MARIATHASAN ,  Sophie M. LEHAR ,  Yan WU ,  Jeanne CHEUNG

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2827 ,  A61K31/7068 ,  A61K39/00 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/1063 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y02A50/492 ,  A61K2300/00

Abstract: The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

公开(公告)号：US20240190966A1

公开(公告)日：2024-06-13

申请号：US18504041

申请日：2023-11-07

Applicant: Genentech, Inc.

Inventor： WeiYu LIN ,  Christoph SPIESS ,  Liping SUN ,  Yan WU ,  Cecilia P.C. CHIU ,  Walter Christian DARBONNE ,  Michael Andrew DILLON

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2824 ,  C07K16/2809 ,  A61K2039/507 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92

Abstract: Provided herein are anti-Ly6G6D (lymphocyte antigen 6 complex, locus G61) antibodies and methods of using the same.

公开(公告)号：US20230279102A1

公开(公告)日：2023-09-07

申请号：US18062956

申请日：2022-12-07

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN ,  Robert J. JOHNSTON ,  Yan WU ,  Wei-Ching LIANG ,  Patrick LUPARDUS ,  Mahesh YADAV ,  Dhaya SESHASAYEE ,  Meredith HAZEN

IPC: C07K16/28 ,  A61K38/17 ,  C07K16/30 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/28 ,  A61K38/177 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K16/3061 ,  A61K2039/507 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/90 ,  C07K2317/94

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US20190330355A1

公开(公告)日：2019-10-31

申请号：US16380865

申请日：2019-04-10

Applicant: GENENTECH, INC.

Inventor： Avi ASHKENAZI ,  Jing QING ,  Christian WIESMANN ,  Yan WU

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/30

Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.

公开(公告)号：US20170362339A1

公开(公告)日：2017-12-21

申请号：US15525791

申请日：2015-11-18

Applicant: Genentech, Inc. ,  Adimab LLC

Inventor： Yichin Liu ,  Jasvinder Atwal ,  Cecilia Pui Chi Chiu ,  Ryan J. Watts ,  Yan WU ,  Eric Krauland ,  Michael Feldhaus

IPC: C07K16/40 ,  G01N33/573 ,  A61K47/68 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K47/6871 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C12Y304/23046 ,  G01N33/573 ,  G01N2333/96472 ,  G01N2800/28 ,  G01N2800/52

Abstract: The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders.

公开(公告)号：US20170275359A1

公开(公告)日：2017-09-28

申请号：US14800588

申请日：2015-07-15

Applicant: Genentech, Inc.

Inventor： Yan WU ,  Minhong YAN

IPC: C07K16/28 ,  C07K16/18 ,  C07K16/22 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/22 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides anti-EphrinB2 antibodies, and compositions comprising and methods of using these antibodies.

公开(公告)号：US20150322153A1

公开(公告)日：2015-11-12

申请号：US14538072

申请日：2014-11-11

Applicant: GENENTECH, INC.

Inventor： Bryan IRVING ,  Henry CHIU ,  Heather MAECKER ,  Sanjeev MARIATHASAN ,  Sophie M. LEHAR ,  Yan WU ,  Jeanne CHEUNG

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/30 ,  A61K45/06 ,  A61K31/7068

CPC classification number: C07K16/2827 ,  A61K31/7068 ,  A61K39/00 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/1063 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y02A50/489 ,  Y02A50/492 ,  A61K2300/00

Abstract: The present application relates to anti-PD-L1 antibodies, which have therapeutic use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

Abstract translation: 本申请涉及抗PD-L1抗体，其具有用于增强T细胞功能以上调细胞介导的免疫应答和用于治疗T细胞功能障碍性疾病（包括感染（例如急性和慢性））和肿瘤的治疗用途 免疫。