公开(公告)号：US20210301005A1

公开(公告)日：2021-09-30

申请号：US17205663

申请日：2021-03-18

Applicant: Genentech, Inc.

Inventor： Wei-Ching LIANG ,  Joseph R. ARRON ,  Daryle DEPIANTO ,  Wendy Green HALPERN ,  WeiYu LIN ,  Patrick J. LUPARDUS ,  Thirumalai Rajan RAMALINGAM ,  Dhaya SESHASAYEE ,  Tianhe SUN ,  Tulika TYAGI ,  Jia WU ,  Yan WU ,  Jian Ping YIN

IPC: C07K16/22 ,  A61P11/00 ,  C07K16/46

Abstract: The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.

公开(公告)号：US20190062836A1

公开(公告)日：2019-02-28

申请号：US15924114

申请日：2018-03-16

Applicant: GENENTECH, INC.

Inventor： Alexander R. ABBAS ,  Joseph R. ARRON ,  Sanjay CHANDRIANI ,  Guiquan JIA ,  Nicholas J.I. LEWIN-KOH ,  Daryle DEPIANTO

IPC: C12Q1/6883 ,  G01N33/68 ,  C07K16/24 ,  A61K39/00 ,  A61K38/00

Abstract: Compositions, kits and methods for assessing the prognosis of idiopathic pulmonary fibrosis in patients are provided. In addition, compositions, kits and methods for diagnosing subtypes of idiopathic pulmonary fibrosis are provided. Also provided are methods for treating idiopathic pulmonary fibrosis.