公开(公告)号：US20240094194A1

公开(公告)日：2024-03-21

申请号：US18518715

申请日：2023-11-24

Applicant: Genentech, Inc.

Inventor： Claudio CIFERRI ,  Evan Michael Green ,  Marc Kschonsak

IPC: G01N33/50 ,  G01N33/569

CPC classification number: G01N33/5091 ,  G01N33/56994 ,  C12N2503/00 ,  G01N2333/045 ,  G01N2469/10

Abstract: Provided herein are methods of treating or preventing human cytomegalovirus (HCMV) infection comprising modulating interactions between the HCMV gH/gL/UL128-131A pentamer and plasma membrane-expressed host cell proteins, as well as methods of identifying modulators of such interactions.

公开(公告)号：US20240295565A1

公开(公告)日：2024-09-05

申请号：US18405256

申请日：2024-01-05

Applicant: Genentech Inc. ,  University of Copenhagen

Inventor： Jian Mehr-Dean Payandeh ,  Stephan Alexander Pless ,  Han Chow Chua ,  Marc Kschonsak

IPC: G01N33/68 ,  C07K14/47 ,  G01N33/557

CPC classification number: G01N33/6872 ,  C07K14/47 ,  G01N33/557

Abstract: The present disclosure relates, inter alia, to complexes of the Na+ leak channel non-selective protein (NALCN) with FAM155A (also called FAM155; Family with sequence similarity 155 member A), UNC79 (uncoordinated 79), and UNC80 (uncoordinated 80), methods of screening for molecules that modulate the activity of the complex, and identified modulators thereof.