公开(公告)号：US20200331968A1

公开(公告)日：2020-10-22

申请号：US16816969

申请日：2020-03-12

Applicant: Genentech, Inc.

Inventor： Emily J. HANAN ,  Georgette CASTANEDO ,  Marie Gabrielle BRAUN ,  Keira GARLAND ,  Peter Andrew SMITH ,  Richard PASTOR ,  Paul GIBBONS ,  Yunxing CHENG ,  Guosheng WU ,  Yuhong FU ,  Po-Wai YUEN

IPC: C07K11/02

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20170368039A1

公开(公告)日：2017-12-28

申请号：US15352184

申请日：2016-11-15

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： BAIR W. Kenneth ,  Timm R. BAUMEISTER ,  Alexandre J. BUCKMELTER ,  Karl H. CLODFELTER ,  Peter DRAGOVICH ,  Francis GOSSELIN ,  Bingsong HAN ,  Jian LIN ,  Dominic J. REYNOLDS ,  Bruce ROTH ,  Chase C. SMITH ,  Zhongguo WANG ,  Po-Wai YUEN ,  Xiaozhang ZHENG

IPC: A61K31/4355 ,  C07D491/048 ,  C07D491/04 ,  C07D487/04 ,  C07D471/04 ,  A61K31/55 ,  A61K31/4365 ,  A61K31/5377 ,  A61K31/519 ,  A61K31/497 ,  A61K31/496 ,  A61K31/437 ,  C07D495/04 ,  A61K45/06

CPC classification number: A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/496 ,  A61K31/497 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:

公开(公告)号：US20160002266A1

公开(公告)日：2016-01-07

申请号：US14382210

申请日：2013-03-01

Applicant: GENENTECH, INC. ,  FORMA TM, LLC

Inventor： Kenneth W BAIR ,  Timm R BAUMEISTER ,  Peter DRAGOVICH ,  Xiongcai LIU ,  Snahel PATEL ,  Po-Wai YUEN ,  Mark ZAK ,  Guiling ZHAO ,  Yamin ZHANG ,  Xiaozhang ZHENG

IPC: C07D519/00 ,  A61K31/438 ,  C07D495/04 ,  C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  C07D471/04 ,  C07D491/048

CPC classification number: C07D519/00 ,  A61K31/438 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04

Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

Abstract translation: 提供酰氨基螺环酰胺和磺酰胺化合物，包含这些化合物的药物组合物，以及使用这些化合物的治疗方法。