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公开(公告)号：US20230130874A1
公开(公告)日：2023-04-27
申请号：US17743727
申请日：2022-05-13
Applicant: Genentech, Inc.
Inventor： Sunil Bhakta , Hans Erickson , Jagath R. Junutula , Katherine Kozak , Rachana Ohri , Thomas Harden Pillow
IPC: C07K16/32 , A61K47/68 , C07K16/18 , C07K16/28 , C07K16/30 , A61K51/10 , C07K16/00 , C07K16/40 , G01N33/58
Abstract: Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody.
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公开(公告)号：US20170260253A1
公开(公告)日：2017-09-14
申请号：US15357545
申请日：2016-11-21
Applicant: Genentech, Inc.
Inventor： Sunil Bhakta , Jagath R. Junutula
CPC classification number: C07K16/00 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6817 , A61K47/6829 , A61K47/6851 , A61K47/6855 , A61K47/6889 , A61K51/1051 , C07K16/3092 , C07K16/32 , C07K2317/52 , C07K2317/55 , C07K2319/31
Abstract: Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody. Certain highly reactive cysteine engineered antibodies were identified by the PHESELECTOR assay. Isolated cysteine engineered antibodies may be covalently attached to a capture label, a detection label, a drug moiety, or a solid support.
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公开(公告)号：US09580514B2
公开(公告)日：2017-02-28
申请号：US14400684
申请日：2013-03-14
Applicant: Genentech, Inc.
Inventor： Sunil Bhakta , Meredith Hazen , Jo-Anne S Hongo , Jagath R Junutula , Isidro Hotzel , Yonglei Shang , Shang-Fan Yu
IPC: A61K39/395 , C07K16/30 , A61K47/48 , A61K51/10 , C12Q1/68 , G01N33/574 , A61K39/00
CPC classification number: C07K16/30 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6855 , A61K51/1051 , A61K2039/505 , A61K2039/6037 , C07K2317/24 , C07K2317/76 , C07K2317/77 , C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , G01N33/57415 , G01N33/57423 , G01N2333/47 , G01N2500/02
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. In certain aspects, the isolated nucleic acid molecule comprises a nucleotide sequence having at least about 80% nucleic acid sequence identity, alternatively at least about 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% nucleic acid sequence identity, to (a) a DNA molecule encoding a full-length TAT polypeptide having an amino acid sequence as disclosed herein, a TAT polypeptide amino acid sequence lacking the signal peptide as disclosed herein, an extracellular domain of a transmembrane TAT polypeptide, with or without the signal peptide, as disclosed herein.
Abstract translation: 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。 在某些方面，分离的核酸分子包含具有至少约80％核酸序列同一性，或至少约81％，82％，83％，84％，85％，86％，87％，88 ％，89％，90％，91％，92％，93％，94％，95％，96％，97％，98％，99％或100％的核酸序列同一性。 如本文公开的具有本文公开的氨基酸序列的全长TAT多肽，缺乏本文公开的信号肽的TAT多肽氨基酸序列，跨膜TAT多肽的胞外结构域，具有或不具有信号肽。
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公开(公告)号：US20200339664A1
公开(公告)日：2020-10-29
申请号：US16787280
申请日：2020-02-11
Applicant: Genentech, Inc.
Inventor： Sunil Bhakta , Jagath R. Junutula
Abstract: Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody. Certain highly reactive cysteine engineered antibodies were identified by the PHESELECTOR assay. Isolated cysteine engineered antibodies may be covalently attached to a capture label, a detection label, a drug moiety, or a solid support.
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公开(公告)号：US20140288280A1
公开(公告)日：2014-09-25
申请号：US14185080
申请日：2014-02-20
Applicant: Genentech, Inc.
Inventor： Sunil Bhakta , Jagath R. Junutula
IPC: A61K47/48
CPC classification number: C07K16/00 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6817 , A61K47/6829 , A61K47/6851 , A61K47/6855 , A61K47/6889 , A61K51/1051 , C07K16/3092 , C07K16/32 , C07K2317/52 , C07K2317/55 , C07K2319/31
Abstract: Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody. Certain highly reactive cysteine engineered antibodies were identified by the PHESELECTOR assay. Isolated cysteine engineered antibodies may be covalently attached to a capture label, a detection label, a drug moiety, or a solid support.
Abstract translation: 在重链或轻链中包含游离半胱氨酸氨基酸的半胱氨酸改造的抗体是通过诱变亲本抗体的核酸序列并用半胱氨酸代替一个或多个氨基酸残基来编码半胱氨酸改造的抗体来制备的; 表达半胱氨酸改造的抗体; 并分离半胱氨酸改造的抗体。 通过PHESELECTOR测定鉴定某些高反应性半胱氨酸工程化抗体。 分离的半胱氨酸改造的抗体可以共价连接到捕获标记，检测标记，药物部分或固体支持物上。
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Patent Agency Ranking
公开(公告)号：US10604557B2
公开(公告)日：2020-03-31
申请号：US15357545
申请日：2016-11-21
Applicant: Genentech, Inc.
Inventor： Sunil Bhakta , Jagath R. Junutula
IPC: A61K39/395 , C07K16/30 , C07K16/28 , A61K47/48 , A61K39/00 , G01N33/574 , C07K16/00 , A61K51/10 , A61K47/68 , C07K16/32
Abstract: Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody. Certain highly reactive cysteine engineered antibodies were identified by the PHESELECTOR assay. Isolated cysteine engineered antibodies may be covalently attached to a capture label, a detection label, a drug moiety, or a solid support.
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公开(公告)号：US10077318B2
公开(公告)日：2018-09-18
申请号：US14851348
申请日：2015-09-11
Applicant: Genentech, Inc.
Inventor： Sunil Bhakta , Hans Erickson , Jagath R. Junutula , Katherine Kozak , Rachana Ohri , Thomas Pillow
IPC: C07K16/00 , C07K16/32 , C07K16/18 , C07K16/28 , C07K16/30 , A61K51/10 , C07K16/40 , G01N33/58 , A61K47/68 , A61K39/00
CPC classification number: C07K16/32 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6849 , A61K47/6869 , A61K51/10 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/3069 , C07K16/3092 , C07K16/40 , C07K2317/40 , C07K2317/73 , C07K2317/94 , G01N33/582
Abstract: Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody.
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公开(公告)号：US20170129963A1
公开(公告)日：2017-05-11
申请号：US15266043
申请日：2016-09-15
Applicant: Genentech, Inc.
Inventor： Sunil Bhakta , Meredith C. Hazen , Jo-Anne S. Hongo , Jagath R. Junutula
CPC classification number: C07K16/30 , C07K16/2809 , C07K2317/31 , C07K2317/565 , C07K2317/73
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20240218050A1
公开(公告)日：2024-07-04
申请号：US18527522
申请日：2023-12-04
Applicant: Genentech, Inc.
Inventor： Sunil Bhakta , Jagath R. Junutula
CPC classification number: C07K16/00 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6817 , A61K47/6829 , A61K47/6851 , A61K47/6855 , A61K47/6889 , A61K51/1051 , C07K16/3092 , C07K16/32 , A61K47/6819 , C07K2317/52 , C07K2317/55 , C07K2319/31
Abstract: Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody. Certain highly reactive cysteine engineered antibodies were identified by the PHESELECTOR assay. Isolated cysteine engineered antibodies may be covalently attached to a capture label, a detection label, a drug moiety, or a solid support.
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公开(公告)号：US11873330B2
公开(公告)日：2024-01-16
申请号：US16787280
申请日：2020-02-11
Applicant: Genentech, Inc.
Inventor： Sunil Bhakta , Jagath R. Junutula
CPC classification number: C07K16/00 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6817 , A61K47/6829 , A61K47/6851 , A61K47/6855 , A61K47/6889 , A61K51/1051 , C07K16/3092 , C07K16/32 , A61K47/6819 , C07K2317/52 , C07K2317/55 , C07K2319/31
Abstract: Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody. Certain highly reactive cysteine engineered antibodies were identified by the PHESELECTOR assay. Isolated cysteine engineered antibodies may be covalently attached to a capture label, a detection label, a drug moiety, or a solid support.
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