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Patent Agency Ranking
公开(公告)号：US20140128580A1
公开(公告)日：2014-05-08
申请号：US14149979
申请日：2014-01-08
Applicant: Genentech, Inc.
Inventor： Allen J. Ebens, JR. , Frederic S. Jacobson , Paul Polakis , Ralph H. Schwall , Mark X. Sliwkowski , Susan D. Spencer
IPC: A61K47/48
CPC classification number: A61K47/6803 , A61K47/6875 , A61K2039/505 , C07D498/18 , C07K16/1063 , C07K16/28 , C07K16/2803 , C07K16/283 , C07K16/2866 , C07K16/2896 , C07K16/3046 , C07K16/3069 , C07K16/32 , C07K2317/24
Abstract: The present invention relates to antibody-drug conjugate compounds of Formula I: Ab-(L-D)p I where one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be used in methods of diagnosis or treatment of cancer, and other diseases and disorders.
Abstract translation: 本发明涉及式I的抗体 - 药物偶联化合物：Ab-（LD）p I，其中一种或多种美登木素生物碱药物部分（D）通过L共价连接到结合ErbB受体的抗体（Ab），或 其结合一种或多种肿瘤相关抗原或细胞表面受体。 这些化合物可用于诊断或治疗癌症及其它疾病和病症的方法中。
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公开(公告)号：US10022452B2
公开(公告)日：2018-07-17
申请号：US15486832
申请日：2017-04-13
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Suzanna J. Scales , Susan D. Spencer , Yin Zhang
IPC: A61K51/10 , C07K16/30 , A61K31/7068 , A61K45/06 , A61K39/395 , A61K38/08 , A61K47/48 , A61K39/00
Abstract: The invention provides anti-mesothelin antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US09695240B2
公开(公告)日：2017-07-04
申请号：US14528142
申请日：2014-10-30
Applicant: Genentech, Inc.
Inventor： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina , Robert L. Cohen
CPC classification number: C07K16/2863 , A61K47/64 , A61K47/6809 , C07K2317/76
Abstract: The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
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公开(公告)号：US09719996B2
公开(公告)日：2017-08-01
申请号：US14539197
申请日：2014-11-12
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Suzanna J. Scales , Susan D. Spencer , Yin Zhang
CPC classification number: A61K47/6851 , A61K31/7068 , A61K38/08 , A61K39/39558 , A61K45/06 , A61K47/48438 , A61K47/48569 , A61K47/48638 , A61K47/6803 , A61K47/6849 , A61K51/1027 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/574 , G01N33/57423 , G01N33/57438 , G01N33/57442 , G01N33/57449 , G01N2333/705
Abstract: The invention provides anti-mesothelin antibodies and immunoconjugates and methods of using the same.
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5.发明申请ANTHRACYCLINE DERIVATIVE CONJUGATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR COMPOUNDS 审中-公开蒽醌衍生物偶联物，其制备方法及其作为抗微生物化合物的用途公开(公告)号：US20150051380A1
公开(公告)日：2015-02-19
申请号：US14528142
申请日：2014-10-30
Applicant: Genentech, Inc.
Inventor： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina , Robert L. Cohen
CPC classification number: C07K16/2863 , A61K47/64 , A61K47/6809 , C07K2317/76
Abstract: The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
Abstract translation: 本发明涉及治疗有用的蒽环类与载体的缀合物，例如天然或合成来源的多克隆和单克隆抗体，蛋白质或肽; 其制备方法，含有它们的药物组合物及其在治疗某些哺乳动物肿瘤中的用途。
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