公开(公告)号：US20210301005A1

公开(公告)日：2021-09-30

申请号：US17205663

申请日：2021-03-18

Applicant: Genentech, Inc.

Inventor： Wei-Ching LIANG ,  Joseph R. ARRON ,  Daryle DEPIANTO ,  Wendy Green HALPERN ,  WeiYu LIN ,  Patrick J. LUPARDUS ,  Thirumalai Rajan RAMALINGAM ,  Dhaya SESHASAYEE ,  Tianhe SUN ,  Tulika TYAGI ,  Jia WU ,  Yan WU ,  Jian Ping YIN

IPC: C07K16/22 ,  A61P11/00 ,  C07K16/46

Abstract: The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.