公开(公告)号：US20150233803A1

公开(公告)日：2015-08-20

申请号：US14702263

申请日：2015-05-01

Applicant: General Electric Company

Inventor： Weston Blaine Griffin ,  Jaydeep Roy ,  Phillip Alexander Shoemaker ,  William Patrick Waters

IPC: G01N1/40

CPC classification number: A61M1/0209 ,  A61M1/0218 ,  A61M1/34 ,  A61M2205/3306 ,  A61M2205/3334 ,  B01D21/26 ,  B03D3/00

Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.

Abstract translation: 一种用于处理生物材料的高通量系统，包括：托盘，其支撑功能封闭的流体路径子系统，包括：用于容纳和使所述生物材料分离成两个或更多个不同的子材料的容器; 从容器接收一个或多个子材料的一个或多个容器; 过滤装置; 导管，至少在所述容器和所述过滤装置之间运送一个或多个副材料; 和第一接合结构; 处理单元，包括：泵送装置，用于经由所述导管在至少所述容器和所述过滤装置之间移动所述副材料中的一种或多种; 对应于第一接合结构的第二接合结构; 用于至少临时将所述托盘相对于所述处理单元暂时保持在固定位置的锁定机构; 响应于一个或多个命令自动启动和停止泵送装置的控制装置。

公开(公告)号：US10088399B2

公开(公告)日：2018-10-02

申请号：US14702263

申请日：2015-05-01

Applicant: General Electric Company

Inventor： Weston Blaine Griffin ,  Jaydeep Roy ,  Phillip Alexander Shoemaker ,  William Patrick Waters

IPC: G01L1/10 ,  G01N1/40

Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.

公开(公告)号：US09347033B2

公开(公告)日：2016-05-24

申请号：US14813406

申请日：2015-07-30

Applicant: General Electric Company

Inventor： Zaeem Ashraf Khan ,  Aaron Joseph Dulgar-Tulloch ,  Stefan Rakuff ,  Philip Alexander Shoemaker ,  Erik Leeming Kvam ,  Xiaohui Chen ,  Jaydeep Roy

IPC: C12N5/077 ,  C12M1/00 ,  B01F5/02 ,  C12M1/02 ,  B01F5/00 ,  B01F5/10

CPC classification number: C12M45/09 ,  B01F5/0057 ,  B01F5/0206 ,  B01F5/0231 ,  B01F5/0256 ,  B01F5/10 ,  C12M27/00 ,  C12M47/04 ,  C12N5/0653 ,  C12N2501/70 ,  C12N2501/734 ,  C12N2521/00

Abstract: A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer, introducing the adipose tissue into the vessel, introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.

Abstract translation: 提供了一种处理脂肪组织以收集脂肪来源的再生细胞的方法，其中所述方法包括提供包含流体喷射混合器的容器，将脂肪组织引入容器中，将缓冲溶液引入容器中; 使用流体喷射混合器洗涤脂肪组织; 将酶溶液引入容器中; 使用流体喷射混合器将包含脂肪组织，酶溶液和缓冲溶液的射流混合到消化脂肪组织以形成消化产物; 将消化产物相分离成消化的浮力脂肪层和非浮力水层; 并收集包含脂肪来源的再生细胞的非浮力水层。 还提供了一种处理脂肪组织以收集脂肪来源的再生细胞的系统。

公开(公告)号：US20150337263A1

公开(公告)日：2015-11-26

申请号：US14813406

申请日：2015-07-30

Applicant: General Electric Company

Inventor： Zaeem Ashraf Khan ,  Aaron Joseph Dulgar-Tulloch ,  Stefan Rakuff ,  Philip Alexander Shoemaker ,  Erik Leeming Kvam ,  Xiaohui Chen ,  Jaydeep Roy

IPC: C12N5/077

CPC classification number: C12M45/09 ,  B01F5/0057 ,  B01F5/0206 ,  B01F5/0231 ,  B01F5/0256 ,  B01F5/10 ,  C12M27/00 ,  C12M47/04 ,  C12N5/0653 ,  C12N2501/70 ,  C12N2501/734 ,  C12N2521/00

Abstract: A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer, introducing the adipose tissue into the vessel, introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.

Abstract translation: 提供了一种处理脂肪组织以收集脂肪来源的再生细胞的方法，其中所述方法包括提供包含流体喷射混合器的容器，将脂肪组织引入容器中，将缓冲溶液引入容器中; 使用流体喷射混合器洗涤脂肪组织; 将酶溶液引入容器中; 使用流体喷射混合器将包含脂肪组织，酶溶液和缓冲溶液的射流混合到消化脂肪组织以形成消化产物; 将消化产物相分离成消化的浮力脂肪层和非浮力水层; 并收集包含脂肪来源的再生细胞的非浮力水层。 还提供了一种处理脂肪组织以收集脂肪来源的再生细胞的系统。

公开(公告)号：US20150169811A1

公开(公告)日：2015-06-18

申请号：US14132313

申请日：2013-12-18

Applicant: General Electric Company

Inventor： Norman Arnold Turnquist ,  Changjie Sun ,  Deepak Trivedi ,  Jaydeep Roy ,  Emad Andarawis Andarawis ,  Murat Inalpolat ,  Arun Karthi Subramaniyan ,  Fernando Javier D'Amato ,  Emrah Biyik

IPC: G06F17/50

CPC classification number: G06F17/5018

Abstract: A method implemented using at least one processor includes receiving a plurality of measured operational parameters of a turbo machine having a rotor and a stator. The plurality of measured operational parameters includes a plurality of real-time operational parameters and a plurality of stored operational parameters. The method further includes generating a finite element model of the turbo machine and generating a plurality of snapshots based on the finite element model and the plurality of stored operational parameters. The method further includes generating a reduced order model based on the plurality of snapshots. The method also includes determining an estimated clearance between the rotor and the stator during operation of the turbo machine, based on the reduced order model and the plurality of real-time operational parameters.

Abstract translation: 使用至少一个处理器实现的方法包括接收具有转子和定子的涡轮机的多个测量的操作参数。 多个测量的操作参数包括多个实时操作参数和多个存储的操作参数。 该方法还包括生成涡轮机的有限元模型，并且基于有限元模型和多个存储的操作参数生成多个快照。 该方法还包括基于多个快照生成缩减订单模型。 所述方法还包括基于所述降序模型和所述多个实时操作参数来确定所述涡轮机的操作期间所述转子和所述定子之间的估计间隙。