公开(公告)号：US20210238609A1

公开(公告)日：2021-08-05

申请号：US17008243

申请日：2020-08-31

Applicant: Genomatica, Inc.

Inventor： Anthony P. Burgard ,  Robin E. Osterhout ,  Priti Pharkya ,  Stefan Andrae ,  Ewa Teresa Lis ,  Carla Risso ,  John Douglas Trawick

IPC: C12N15/63 ,  C12P5/02 ,  C12P7/04 ,  C12P7/18 ,  C12N9/88 ,  C07K14/195 ,  C12N15/52 ,  C12N9/10 ,  C12N9/90 ,  C07C1/24 ,  C07C11/167 ,  C07C31/20 ,  C07C33/025 ,  C09D147/00 ,  C09J147/00

Abstract: Provided herein are non-naturally occurring microbial organisms having a FaldFP, a FAP and/or metabolic modifications which can further include a MMP, a MOP, a hydrogenase and/or a CODH. These microbial organisms can further include a butadiene, 13BDO, CrotOH, MVC or 3-buten-1-ol pathway. Additionally provided are methods of using such microbial organisms to produce butadiene, 13BDO, CrotOH, MVC or 3-buten-1-ol.