公开(公告)号：US12098168B2

公开(公告)日：2024-09-24

申请号：US17271442

申请日：2019-08-29

Applicant: Genomatica, Inc.

Inventor： Stephen Thomas Payne ,  Scott Allen Frykman ,  Bernardo Moura Torres Da Costa ,  Isolde Callihan ,  Sankaranarayanan Venkiteswaran ,  Leland Ken Wong

IPC: C07K14/245 ,  C12N1/22 ,  C12N9/02 ,  C12N9/06 ,  C12N9/10 ,  C12N9/18 ,  C12P7/6436

CPC classification number: C07K14/245 ,  C12N1/22 ,  C12N9/0008 ,  C12N9/0014 ,  C12N9/0077 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/18 ,  C12P7/6436 ,  C12Y102/99006 ,  C12Y104/99003 ,  C12Y114/15003 ,  C12Y203/01075 ,  C12Y206/01001 ,  C12Y301/01067

Abstract: The disclosure relates to mutant gene(s) that confer upon microorganisms that express them an improved capacity to utilize xylose and improved capacity to co-utilize glucose and xylose thereby resulting in improved growth of the microorganism. Further encompassed are methods of producing fatty acids and fatty acid derivatives from cellulosic biomass, xylose, and/or a glucose/xylose mix by employing the host cells expressing the engineered XylR variants and compositions of biologically produced fatty acids and fatty acid derivatives.