公开(公告)号：US09694063B2

公开(公告)日：2017-07-04

申请号：US14363387

申请日：2012-12-07

申请人： GlaxoSmithKline Biologicals SA

发明人： Maria Scarselli ,  Mariagrazia Pizza ,  Rosanna Leuzzi ,  Maria Arico ,  Manuele Martinelli ,  Gillian Douce

IPC分类号： A61K39/08 ,  C07K14/33 ,  A61K39/00

CPC分类号： A61K39/08 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/70 ,  C07K14/33 ,  C07K2319/20

摘要： The present invention relates to recombinant fragments of C. difficile TcdA and TcdB that may be used in the development of vaccines against C. difficile associated disease. More particularly it relates to combinations comprising a ToxB-GT antigen and a TcdA antigen or a ToxA-GT antigen and a TcdB antigen.