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公开(公告)号:US09694063B2
公开(公告)日:2017-07-04
申请号:US14363387
申请日:2012-12-07
发明人: Maria Scarselli , Mariagrazia Pizza , Rosanna Leuzzi , Maria Arico , Manuele Martinelli , Gillian Douce
CPC分类号: A61K39/08 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C07K14/33 , C07K2319/20
摘要: The present invention relates to recombinant fragments of C. difficile TcdA and TcdB that may be used in the development of vaccines against C. difficile associated disease. More particularly it relates to combinations comprising a ToxB-GT antigen and a TcdA antigen or a ToxA-GT antigen and a TcdB antigen.
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公开(公告)号:US11021522B2
公开(公告)日:2021-06-01
申请号:US16458365
申请日:2019-07-01
IPC分类号: A61P37/04 , C07K14/22 , A61K39/095 , A61K39/00
摘要: Modified meningococcal fHbp polypeptides with increased stability.
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公开(公告)号:US10392424B2
公开(公告)日:2019-08-27
申请号:US15120674
申请日:2015-02-27
IPC分类号: A61K39/095 , C07K14/22 , A61K39/00
摘要: Modified meningococcal fHbp polypeptides with increased stability.
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公开(公告)号:US11932671B2
公开(公告)日:2024-03-19
申请号:US17245681
申请日:2021-04-30
IPC分类号: A61P37/04 , A61K39/095 , C07K14/22 , A61K39/00
CPC分类号: C07K14/22 , A61K39/095 , A61K2039/523 , A61K2039/55511 , A61K2039/70
摘要: Modified meningococcal fHbp polypeptides with increased stability.
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公开(公告)号:US09932374B2
公开(公告)日:2018-04-03
申请号:US14425037
申请日:2013-09-19
发明人: Cesira Galeotti , Rosanna Leuzzi , Mariagrazia Pizza , Maria Scarselli , Meera Unnikrishnan , Manuele Martinelli
CPC分类号: C07K14/33 , A61K39/08 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C07K16/1282
摘要: The invention provides methods, proteins, nucleic acids and antibodies for preventing or treating a C. difficile infection in a mammal.
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