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公开(公告)号：US10995310B2
公开(公告)日：2021-05-04
申请号：US15755087
申请日：2016-08-25
发明人： Praveen Paul , Manoj Ramakrishna , Anoop Bhargav , Haresh Digambar Patil , Sebastian John , Manish Uddhaorao Choudhary , Pradeep Kumar , Nivedita Phadke
摘要： Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; the tray support further including a load cell (41) to determine changes in the mass load on the tray.
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公开(公告)号：US10934518B2
公开(公告)日：2021-03-02
申请号：US15545395
申请日：2016-01-29
发明人： Haresh Digambar Patil , Manoj Ramakrishna , Anoop Bhargav , Praveen Paul , Sebastian John , Swapnil Puranik
摘要： The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which has several integrated functions and enables small scale static culture as well as scale-up rocking culture in the same bioreactor. The bioreactor system comprises tray for positioning of a cell culture bag having adjustable volume, a lid covering the cell culture bag and provided with heating function, an integrated perfusion unit, an integrated cell loading unit, and an integrated unit for automatic cell culture sampling, wherein the bioreactor system is controlled by a single control unit. The invention also relates to a method of cell culture using the bioreactor system for culture of therapeutic cells.
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公开(公告)号：US11525112B2
公开(公告)日：2022-12-13
申请号：US16474316
申请日：2017-12-22
发明人： Manoj Ramakrishna , Anoop Bhargav , Umesh Pai
摘要： Disclosed is a cell culture system comprising a first cell culture bioreactor system (10) for culturing cells to a predetermined cell density or quantity, the system including a bioreactor volume (20), a process controller (30), process control devices (32) which provide inputs (16) for the culture volume and culture parameter measurement devices (14), wherein the process controller is operable according to plural control program steps to control the process devices to provide inputs for a suitable cell culture environment in the bioreactor volume, and is further operable according to control program steps modified by feedback values from the culture parameter measurement devices, and comprises a memory (36) operable to record data indicative of the progress of the control program steps. Failure of the system can be rectified by moving the bioreactor volume to another similar system which has access to data indicative of any incomplete program steps which steps may have been modified by feedback from the measurement devices.
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公开(公告)号：US11452976B2
公开(公告)日：2022-09-27
申请号：US16474376
申请日：2017-12-22
摘要： The present invention relates to a mixing system for a bioreactor, comprising a plurality of supply units (10), each being able to hold media for use in a bioreactor a mixing unit (30) for creating a uniform mixing of media a first feeding mechanism (20), arranged to feed media from the supply units (10) into the mixing unit (30), a control unit (40) operatively connected to the first feeding mechanism (20) and the mixing unit (30), said control unit (40) being configured to control the first feeding mechanism (20) to feed predetermined amounts of media from the plurality of supply units (10) to the mixing unit (30), and further being configured to control the mixing unit (30) to create a uniform mixing of media. The invention also relates to a method for mixing media for use in a bioreactor.
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公开(公告)号：US11326142B2
公开(公告)日：2022-05-10
申请号：US15755086
申请日：2016-08-25
摘要： Disclosed is a biomanufacturing apparatus (1) comprising a housing (20) including top (22) and bottom (24) faces which allow stacking of plural housings, an access door (25) at a front side of the housing, a substantially enclosed bioreactor chamber (30) inside the housing accessible via the door, and a further substantially enclosed region (36) inside the housing containing electrical parts and/or electronic control components, the chamber (30) including: a tray (40/240) for supporting a bioreactor, a tray support (45/245) including a mechanism (44,47/244,247) for rocking the tray in use; the tray having complementary formations allowing movement of tray relative to the tray support toward the front side to allow more convenient access to the bioreactor.
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公开(公告)号：US10995312B2
公开(公告)日：2021-05-04
申请号：US15755084
申请日：2016-08-25
发明人： Haresh Digambar Patil , Praveen Paul , Manish Uddhaorao Choudhary , Pradeep Kumar , Anoop Bhargav , Sebastian John , Nivedita Phadke , Manoj Ramakrishna
摘要： Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; at least a fluid handling portion 48,49 of at least one fluid pump device 54/58; and at least one connection 43 for connecting to a conduit and/or path for carrying fluids, gas and/or electricity.
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