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公开(公告)号：US5654295A
公开(公告)日：1997-08-05
申请号：US524557
申请日：1995-09-07
IPC分类号： A61K31/55 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , C07D223/16 , C07D401/04 , C07D403/04 , C07D403/12
CPC分类号： C07D223/16 , A61K31/55 , C07D401/04 , C07D403/04 , C07D403/12
摘要： Benz[b]azepine compounds, pharmaceutical compositions containing them and methods for the treatment of neurological disorders utilizing them.
摘要翻译： 苯并[b]吖庚因化合物，含有它们的药物组合物和用于治疗利用它们的神经障碍的方法。
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公开(公告)号：US5712272A
公开(公告)日：1998-01-27
申请号：US782279
申请日：1997-01-13
IPC分类号： A61K31/55 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , C07D223/16 , C07D401/04 , C07D403/04 , C07D403/12
CPC分类号： C07D223/16 , A61K31/55 , C07D401/04 , C07D403/04 , C07D403/12
摘要： Benz�b!azepine compounds, pharmaceutical compositions containing them and methods for the treatment of neurological disorders utilizing them.
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公开(公告)号：US06214826B1
公开(公告)日：2001-04-10
申请号：US09365562
申请日：1999-08-02
申请人： Thomas Michael Bare , Marc Jerome Chapdelaine , Timothy Wayne Davenport , James Roy Empfield , Laura Enid Garcia-Davenport , Paul Francis Jackson , Jeffrey Alan McKinney , Charles David McLaren , Richard Bruce Sparks
发明人： Thomas Michael Bare , Marc Jerome Chapdelaine , Timothy Wayne Davenport , James Roy Empfield , Laura Enid Garcia-Davenport , Paul Francis Jackson , Jeffrey Alan McKinney , Charles David McLaren , Richard Bruce Sparks
IPC分类号： A61K315025
CPC分类号： C07D471/04
摘要： The invention relates to pyridazinoquinoline compounds of the formulas B and B′ wherein Ring A is selected from an ortho fused aromatic or heteroaromatic five- or six-membered ring and R1, R3 and R4 are substituents selected from halo, OH, OCF3, NO2, CN, NR′R″, SO2NR′R″, SOmR′alkyl, and a variety of alkyl, aryl, heterocyclic and heteroaryl groups, to pharmaceutical compositions containing them and to methods utilizing them for the treatment of neurological disorders.
摘要翻译： 本发明涉及式B和B'的哒嗪喹啉化合物，其中环A选自邻稠合芳族或杂芳族五元或六元环，且R 1，R 3和R 4为选自卤素，OH，OCF 3，NO 2， CN，NR'R“，SO2NR'R”，SOmR'烷基，以及各种烷基，芳基，杂环和杂芳基，含有它们的药物组合物以及利用它们用于治疗神经障碍的方法。
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公开(公告)号：US5801168A
公开(公告)日：1998-09-01
申请号：US794102
申请日：1997-02-03
申请人： Marc Jerome Chapdelaine , Timothy W. Davenport , Laura E. Garcia-Davenport , Paul Francis Jackson , Jeffrey A. McKinney , Charles D. McLaren
发明人： Marc Jerome Chapdelaine , Timothy W. Davenport , Laura E. Garcia-Davenport , Paul Francis Jackson , Jeffrey A. McKinney , Charles D. McLaren
IPC分类号： C07D223/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07F7/08 , A61K31/55
CPC分类号： C07D223/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07F7/0812
摘要： Antagonists at the NMDA receptor complex which are benz�b!azepines having a hydroxy, alkoxy or amino substituent at the 3-position and a 4-position alkenyl, alkynyl, aryl or heteroaryl substituent for treatment of stroke and/or other neurodegenerative disorders.
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公开(公告)号：US5656626A
公开(公告)日：1997-08-12
申请号：US547696
申请日：1995-10-19
申请人： Marc Jerome Chapdelaine , Timothy W. Davenport , Laura E. Garcia-Davenport , Paul Francis Jackson , Jeffrey A. McKinney , Charles D. McLaren
发明人： Marc Jerome Chapdelaine , Timothy W. Davenport , Laura E. Garcia-Davenport , Paul Francis Jackson , Jeffrey A. McKinney , Charles D. McLaren
IPC分类号： A61K31/55 , A61P25/00 , A61P25/28 , C07D223/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07F7/08
CPC分类号： C07D223/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07F7/0812
摘要： Antagonists at the NMDA receptor complex which are benz[b]azepines having a hydroxy, alkoxy or amino substituent at the 3-position and a 4-position alkenyl, alkynyl, aryl or heteroaryl substituent for treatment of stroke and/or other neurodegenerative disorders.
摘要翻译： NMDA受体复合物的拮抗剂是苯并[b]吖庚因，其在3-位上具有羟基，烷氧基或氨基取代基，以及4-位烯基，炔基，芳基或杂芳基取代基，用于治疗中风和/或其它神经变性疾病。
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6.发明申请公开(公告)号：US20120129872A1
公开(公告)日：2012-05-24
申请号：US13297395
申请日：2011-11-16
申请人： Kristi Anne Leonard , Yan Zhang , Brett Andrew Tounge , Aihua Wang , Michael Hawkins , Paul Francis Jackson , Joseph Kent Barbay , Umar S.M. Maharoof
发明人： Kristi Anne Leonard , Yan Zhang , Brett Andrew Tounge , Aihua Wang , Michael Hawkins , Paul Francis Jackson , Joseph Kent Barbay , Umar S.M. Maharoof
IPC分类号： A61K31/496 , C07D417/04 , C07D471/04 , C07D417/14 , A61K31/427 , A61K31/437 , A61P35/00 , A61P19/02 , A61P19/08 , A61P9/00 , A61P1/04 , A61P9/12 , A61P11/00 , A61P29/00 , A61P1/00 , A61P17/02 , A61P25/00 , A61P11/06 , A61P25/06 , A61P13/12 , A61P9/10 , C07D417/10
CPC分类号： C07D417/12 , C07D417/14 , C07D471/04
摘要： This invention relates to thiazole I and its therapeutic and prophylactic uses, wherein the variables A, Q, J, R1, R3, and R5 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.
摘要翻译： 本发明涉及噻唑I及其治疗和预防用途，其中变量A，Q，J，R 1，R 3和R 5在本说明书中定义。 治疗和/或预防的疾病包括类风湿性关节炎。
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7.发明授权
公开(公告)号：US5652239A
公开(公告)日：1997-07-29
申请号：US545229
申请日：1995-10-19
IPC分类号： A61K31/50 , A61K31/5025 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/28 , C07D471/14 , C07D487/04 , C07D495/14
CPC分类号： C07D471/14 , C07D487/04 , C07D495/14
摘要： The present invention relates to pyridazino[4,5-b]indoles, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides pharmaceutical compositions containing pyridazino[4,5-b]indoles as active ingredient, and methods for the treatment of neurological disorders.
摘要翻译： 本发明涉及哒嗪并[4,5-B]吲哚，并且当这样的需要拮抗如在神经系统病症的治疗药学上有用的盐，它们是兴奋性氨基酸拮抗剂，并且是有用的。 本发明还提供含有哒嗪并[4,5-b]吲哚作为活性成分的药物组合物，以及治疗神经障碍的方法。
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8.发明申请公开(公告)号：US20120129897A1
公开(公告)日：2012-05-24
申请号：US13297386
申请日：2011-11-16
申请人： Joseph Kent Barbay , Kristi Anne Leonard , Yan Zhang , Brett Andrew Tounge , Aihua Wang , Michael Hawkins , Paul Francis Jackson , Umar S.M. Maharoof
发明人： Joseph Kent Barbay , Kristi Anne Leonard , Yan Zhang , Brett Andrew Tounge , Aihua Wang , Michael Hawkins , Paul Francis Jackson , Umar S.M. Maharoof
IPC分类号： A61K31/427 , A61P35/00 , A61P19/02 , A61P19/08 , A61P9/00 , A61P1/04 , A61P9/12 , A61P11/00 , A61P29/00 , A61P1/00 , A61P1/02 , A61P17/02 , A61P1/16 , A61P25/00 , A61P11/06 , A61P25/06 , A61P9/10 , C07D417/04
CPC分类号： C07D417/04
摘要： This invention relates to thiazole I and its therapeutic and prophylactic uses, wherein the variables A, Q, J, R1, R3, and R5 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.
摘要翻译： 本发明涉及噻唑I及其治疗和预防用途，其中变量A，Q，J，R 1，R 3和R 5在本说明书中定义。 治疗和/或预防的疾病包括类风湿性关节炎。
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