公开(公告)号：US5801168A

公开(公告)日：1998-09-01

申请号：US794102

申请日：1997-02-03

申请人： Marc Jerome Chapdelaine ,  Timothy W. Davenport ,  Laura E. Garcia-Davenport ,  Paul Francis Jackson ,  Jeffrey A. McKinney ,  Charles D. McLaren

发明人： Marc Jerome Chapdelaine ,  Timothy W. Davenport ,  Laura E. Garcia-Davenport ,  Paul Francis Jackson ,  Jeffrey A. McKinney ,  Charles D. McLaren

IPC分类号： C07D223/16 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07F7/08 ,  A61K31/55

CPC分类号： C07D223/16 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07F7/0812

摘要： Antagonists at the NMDA receptor complex which are benz�b!azepines having a hydroxy, alkoxy or amino substituent at the 3-position and a 4-position alkenyl, alkynyl, aryl or heteroaryl substituent for treatment of stroke and/or other neurodegenerative disorders.

公开(公告)号：US5656626A

公开(公告)日：1997-08-12

申请号：US547696

申请日：1995-10-19

申请人： Marc Jerome Chapdelaine ,  Timothy W. Davenport ,  Laura E. Garcia-Davenport ,  Paul Francis Jackson ,  Jeffrey A. McKinney ,  Charles D. McLaren

发明人： Marc Jerome Chapdelaine ,  Timothy W. Davenport ,  Laura E. Garcia-Davenport ,  Paul Francis Jackson ,  Jeffrey A. McKinney ,  Charles D. McLaren

IPC分类号： A61K31/55 ,  A61P25/00 ,  A61P25/28 ,  C07D223/16 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07F7/08

CPC分类号： C07D223/16 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07F7/0812

摘要： Antagonists at the NMDA receptor complex which are benz[b]azepines having a hydroxy, alkoxy or amino substituent at the 3-position and a 4-position alkenyl, alkynyl, aryl or heteroaryl substituent for treatment of stroke and/or other neurodegenerative disorders.

摘要翻译： NMDA受体复合物的拮抗剂是苯并[b]吖庚因，其在3-位上具有羟基，烷氧基或氨基取代基，以及4-位烯基，炔基，芳基或杂芳基取代基，用于治疗中风和/或其它神经变性疾病。

公开(公告)号：US5502048A

公开(公告)日：1996-03-26

申请号：US255613

申请日：1994-06-09

申请人： Marc J. Chapdelaine ,  Timothy W. Davenport ,  Laura E. Garcia-Davenport ,  Paul F. Jackson ,  Jeffrey A. McKinney ,  Charles D. McLaren

发明人： Marc J. Chapdelaine ,  Timothy W. Davenport ,  Laura E. Garcia-Davenport ,  Paul F. Jackson ,  Jeffrey A. McKinney ,  Charles D. McLaren

IPC分类号： A61K31/55 ,  A61P25/00 ,  A61P25/28 ,  C07D223/16 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07F7/08

CPC分类号： C07D223/16 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07F7/0812

摘要： Antagonists at the NMDA receptor complex which are benz b!azepines having a hydroxy, alkoxy or amino substituent at the 3-position and a 4-position alkenyl, alkynyl, aryl or heteroaryl substituent for treatment of stroke and/or other neurodegenerative disorders.

摘要翻译： NMDA受体复合物的拮抗剂是苯并[b]吖庚因，其在3-位上具有羟基，烷氧基或氨基取代基，以及4-位烯基，炔基，芳基或杂芳基取代基，用于治疗中风和/或其它神经变性疾病。

公开(公告)号：US20120172487A1

公开(公告)日：2012-07-05

申请号：US13374556

申请日：2012-01-03

申请人： Jeffrey A. McKinney

发明人： Jeffrey A. McKinney

IPC分类号： A61F2/28

CPC分类号： A61L27/425 ,  A61L2430/02

摘要： The present invention generally relates to an artificial bone composition, methods of making the composition, and methods of using the artificial bone. In one aspect, the present invention is directed to a composition for inclusion in artificial bone. The composition includes hydroxyapatite and between 0.5 weight percent and 1.5 weight percent of a polymer. The composition has a microstructure substantially similar to a marine carbonate skeleton.

摘要翻译： 本发明一般涉及人造骨组合物，制造组合物的方法和使用人造骨的方法。 一方面，本发明涉及包含在人造骨中的组合物。 组合物包括羟基磷灰石和0.5重量％至1.5重量％的聚合物。 该组合物具有与海洋碳酸盐骨架基本相似的微结构。

公开(公告)号：US20110046236A1

公开(公告)日：2011-02-24

申请号：US12777238

申请日：2010-05-10

申请人： Anthony W. Czarnik ,  Jeffrey A. McKinney

发明人： Anthony W. Czarnik ,  Jeffrey A. McKinney

IPC分类号： A61K31/045 ,  C12H1/14 ,  C12C12/00

CPC分类号： C12G3/08 ,  A23V2002/00 ,  A61K9/0095 ,  A61K9/08 ,  A61K31/045 ,  A61K47/10 ,  C12C12/00 ,  C12G1/00 ,  C12G3/04 ,  A23V2200/334

摘要： The present invention provides beverages and pharmaceutical compositions containing a deuterated alcohol according to Formula 1, and provides methods for their manufacture and use. The compositions of the invention are expected to ameliorate some of the negative side effects associated with the consumption of alcohol, such as hangover and facial flushing.

摘要翻译： 本发明提供含有根据式1的氘代醇的饮料和药物组合物，并提供其制造和使用的方法。 预期本发明的组合物可改善与酒精消耗相关的一些负面副作用，例如宿醉和面部潮红。

公开(公告)号：US20100297265A1

公开(公告)日：2010-11-25

申请号：US12800485

申请日：2010-05-17

申请人： Jeffrey A. McKinney

发明人： Jeffrey A. McKinney

IPC分类号： A61K33/10 ,  A61P43/00

CPC分类号： A61Q11/00 ,  A61K8/36 ,  A61K9/0056 ,  A61K9/0058 ,  A61K9/006 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention generally relates to compositions and methods for oral care. In particular it relates to optimal compositions and methods for treating oral disease and pain where the compositions include cesium and/or rubidium. In a composition aspect, the present invention provides a composition for treating oral disease or oral pain. The composition includes cesium bicarbonate, rubidium bicarbonate, or a mixture of cesium bicarbonate and rubidium bicarbonate at a concentration between 40 mM and 110 mM in an aqueous solution. The composition has a pH between 7.0 and 9.0.

摘要翻译： 本发明一般涉及口腔护理的组合物和方法。 特别涉及用于治疗口腔疾病和疼痛的最佳组合物和方法，其中组合物包括铯和/或铷。 在组合物方面，本发明提供了一种治疗口腔疾病或口腔疼痛的组合物。 该组合物包含在水溶液中浓度为40mM和110mM的碳酸氢铯，碳酸氢铷或碳酸氢铯和碳酸氢铷的混合物。 该组合物的pH为7.0-9.0。

公开(公告)号：US20090229600A1

公开(公告)日：2009-09-17

申请号：US12471070

申请日：2009-05-22

申请人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

IPC分类号： A61M11/00

CPC分类号： A61M11/044 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/235 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/519 ,  A61M11/001 ,  A61M11/02 ,  A61M15/00 ,  A61M15/0028 ,  A61M16/109 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04

摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy

摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中涂覆的组合物为小于10μm厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶

公开(公告)号：US20130032139A1

公开(公告)日：2013-02-07

申请号：US13569006

申请日：2012-08-07

申请人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Amy T. Lu ,  Daniel J. Myers ,  Joshua D. Rabinowitz ,  Martin J. Wensley ,  Jeffrey A. McKinney ,  Alejandro C. Zaffaroni

发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Amy T. Lu ,  Daniel J. Myers ,  Joshua D. Rabinowitz ,  Martin J. Wensley ,  Jeffrey A. McKinney ,  Alejandro C. Zaffaroni

IPC分类号： A61M11/04

CPC分类号： A61K9/0004 ,  A61K9/007 ,  A61K9/0078 ,  A61K9/12 ,  A61K31/4468 ,  A61K31/519 ,  A61K31/5415 ,  A61K31/5517 ,  A61K31/553 ,  A61M11/002 ,  A61M11/005 ,  A61M11/04 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047 ,  A61M15/00 ,  A61M2207/00

摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided, wherein the device, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Methods for use are also disclosed.

摘要翻译： 本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。 这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。 这些气溶胶是通过在使薄膜上的气体通过膜的同时快速加热涂覆有厚度为0.05至20μm的药物薄膜的基材，形成用于吸入的理想颗粒尺寸的颗粒。 还提供了包含药物和用于产生冷凝气雾剂的装置的试剂盒，其中所述装置具有用于加热药物的元件，所述元件作为膜涂覆在基底上并且当施用药物时含有治疗有效剂量的药物 气溶胶形式，以及允许蒸汽冷却以形成气溶胶的元素。 还公开了使用方法。

公开(公告)号：US20110240013A1

公开(公告)日：2011-10-06

申请号：US13078606

申请日：2011-04-01

申请人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

IPC分类号： A61M11/00

CPC分类号： A61M11/044 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/235 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/519 ,  A61M11/001 ,  A61M11/02 ,  A61M15/00 ,  A61M15/0028 ,  A61M16/109 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04

摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming a vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中所述涂覆的组合物为小于10μ厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。

公开(公告)号：US07537009B2

公开(公告)日：2009-05-26

申请号：US10146088

申请日：2002-05-13

申请人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

IPC分类号： A61L9/04

CPC分类号： A61M11/044 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/235 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/519 ,  A61M11/001 ,  A61M11/02 ,  A61M15/00 ,  A61M15/0028 ,  A61M16/109 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04

摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10 μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物以形成蒸气的基底，其中涂覆的组合物为小于10微米的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。