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公开(公告)号：US20130248849A1
公开(公告)日：2013-09-26
申请号：US13990832
申请日：2011-12-19
申请人： Jerals Feldman , Norman Herron , Michael Henry Howard, JR. , Nora Sabina Radu , Vsevolod Rostovtsev , Kerwin D. Dobbs , Adam Fennimore , Weiying Gao , Weishi Wu , Ying Wang , Charles D. Mclaren
发明人： Jerals Feldman , Norman Herron , Michael Henry Howard, JR. , Nora Sabina Radu , Vsevolod Rostovtsev , Kerwin D. Dobbs , Adam Fennimore , Weiying Gao , Weishi Wu , Ying Wang , Charles D. Mclaren
IPC分类号： H01L51/00
CPC分类号： H01L51/0072 , C09K11/025 , C09K11/06 , C09K2211/1003 , C09K2211/1029 , C09K2211/1059 , C09K2211/185 , H01L51/0061 , H01L51/0067 , H01L51/0074 , H01L51/0085 , H01L51/0087 , H01L51/0558 , H01L51/5016 , H01L2251/5384 , H05B33/14
摘要： This invention relates to a composition including (a) a dopant, (b) a first host having at least one unit of Formula I, and (c) a second host compound. Formula I has the structure where Q is a fused ring linkage having the formula In Formula I: R1 is the same or different at each occurrence and is D, alkyl, aryl, silyl, alkoxy, aryloxy, cyano, vinyl, or allyl; R2 is the same or different at each occurrence and is H, D, alkyl, or aryl, or both R2 are an N-heterocycle; R3 is the same or different at each occurrence and is H, D, cyano, alkyl or aryl; and a is the same or different at each occurrence and is an integer from 0-4.
摘要翻译： 本发明涉及包含（a）掺杂剂，（b）具有至少一个式I单元的第一主体和（c）第二主体化合物的组合物。 式I具有结构式，其中Q为具有式I的稠环键。式I中：R 1在每次出现时相同或不同，为D，烷基，芳基，甲硅烷基，烷氧基，芳氧基，氰基，乙烯基或烯丙基; R2在每次出现时相同或不同，为H，D，烷基或芳基，或两者均为N-杂环; R 3在每次出现时相同或不同，为H，D，氰基，烷基或芳基; 并且a在每次出现时相同或不同，为0-4的整数。
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公开(公告)号：US5801168A
公开(公告)日：1998-09-01
申请号：US794102
申请日：1997-02-03
申请人： Marc Jerome Chapdelaine , Timothy W. Davenport , Laura E. Garcia-Davenport , Paul Francis Jackson , Jeffrey A. McKinney , Charles D. McLaren
发明人： Marc Jerome Chapdelaine , Timothy W. Davenport , Laura E. Garcia-Davenport , Paul Francis Jackson , Jeffrey A. McKinney , Charles D. McLaren
IPC分类号： C07D223/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07F7/08 , A61K31/55
CPC分类号： C07D223/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07F7/0812
摘要： Antagonists at the NMDA receptor complex which are benz�b!azepines having a hydroxy, alkoxy or amino substituent at the 3-position and a 4-position alkenyl, alkynyl, aryl or heteroaryl substituent for treatment of stroke and/or other neurodegenerative disorders.
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公开(公告)号：US5656626A
公开(公告)日：1997-08-12
申请号：US547696
申请日：1995-10-19
申请人： Marc Jerome Chapdelaine , Timothy W. Davenport , Laura E. Garcia-Davenport , Paul Francis Jackson , Jeffrey A. McKinney , Charles D. McLaren
发明人： Marc Jerome Chapdelaine , Timothy W. Davenport , Laura E. Garcia-Davenport , Paul Francis Jackson , Jeffrey A. McKinney , Charles D. McLaren
IPC分类号： A61K31/55 , A61P25/00 , A61P25/28 , C07D223/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07F7/08
CPC分类号： C07D223/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07F7/0812
摘要： Antagonists at the NMDA receptor complex which are benz[b]azepines having a hydroxy, alkoxy or amino substituent at the 3-position and a 4-position alkenyl, alkynyl, aryl or heteroaryl substituent for treatment of stroke and/or other neurodegenerative disorders.
摘要翻译： NMDA受体复合物的拮抗剂是苯并[b]吖庚因，其在3-位上具有羟基，烷氧基或氨基取代基，以及4-位烯基，炔基，芳基或杂芳基取代基，用于治疗中风和/或其它神经变性疾病。
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公开(公告)号：US5502048A
公开(公告)日：1996-03-26
申请号：US255613
申请日：1994-06-09
申请人： Marc J. Chapdelaine , Timothy W. Davenport , Laura E. Garcia-Davenport , Paul F. Jackson , Jeffrey A. McKinney , Charles D. McLaren
发明人： Marc J. Chapdelaine , Timothy W. Davenport , Laura E. Garcia-Davenport , Paul F. Jackson , Jeffrey A. McKinney , Charles D. McLaren
IPC分类号： A61K31/55 , A61P25/00 , A61P25/28 , C07D223/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07F7/08
CPC分类号： C07D223/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07F7/0812
摘要： Antagonists at the NMDA receptor complex which are benz b!azepines having a hydroxy, alkoxy or amino substituent at the 3-position and a 4-position alkenyl, alkynyl, aryl or heteroaryl substituent for treatment of stroke and/or other neurodegenerative disorders.
摘要翻译： NMDA受体复合物的拮抗剂是苯并[b]吖庚因，其在3-位上具有羟基，烷氧基或氨基取代基，以及4-位烯基，炔基，芳基或杂芳基取代基，用于治疗中风和/或其它神经变性疾病。
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公开(公告)号：US5446039A
公开(公告)日：1995-08-29
申请号：US96795
申请日：1993-07-23
IPC分类号： C07D223/16 , A61K31/55 , A61P9/00 , A61P25/00 , A61P25/28
CPC分类号： C07D223/16
摘要： A method for the treatment of neurological disorders, comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I or of formula II (formulae set out on pages following the Examples), whereinR.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently selected from:hydrogen,(1-3C)perfluoroalkyl,halo, nitro and cyano;R.sup.5 is a (1-5C)alkyl group;or a pharmaceutically acceptable salt thereof.Also provided are compounds and pharmaceutical compositions suitable for the treatment of neurological disorders.
摘要翻译： 一种治疗神经系统疾病的方法，包括向需要这种治疗的哺乳动物施用有效量的式I或式II化合物（实施例之后的页面上列出的式），其中R1，R2，R3和 R4独立地选自：氢，（1-3C）全氟烷基，卤素，硝基和氰基; R5是（1-5C）烷基; 或其药学上可接受的盐。 还提供了适用于治疗神经障碍的化合物和药物组合物。
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公开(公告)号：US5254683A
公开(公告)日：1993-10-19
申请号：US816327
申请日：1991-12-31
IPC分类号： C07D223/16 , A61K31/55 , A61P9/00 , A61P25/00 , A61P25/28
CPC分类号： C07D223/16
摘要： A method for the treatment of neurological disorders, comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I or of formula II (formulae set out on pages following the Examples), whereinR.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently selected from:hydrogen,(1-3C)perfluoroalkyl,halo, nitro and cyano;R.sup.5 is a (1-5C)alkyl group;or a pharmaceutically acceptable salt thereof.Also provided are compounds and pharmaceutical compositions suitable for the treatment of neurological disorders.
摘要翻译： 一种治疗神经系统疾病的方法，包括向需要这种治疗的哺乳动物施用有效量的式I或式II化合物（实施例之后的页面上列出的式），其中R1，R2，R3和 R4独立地选自：氢，（1-3C）全氟烷基，卤素，硝基和氰基; R5是（1-5C）烷基; 或其药学上可接受的盐。 还提供了适用于治疗神经障碍的化合物和药物组合物。
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公开(公告)号：US09293716B2
公开(公告)日：2016-03-22
申请号：US13990832
申请日：2011-12-19
申请人： Jerald Feldman , Norman Herron , Michael Henry Howard, Jr. , Nora Sabina Radu , Vsevolod Rostovtsev , Kerwin D Dobbs , Adam Fennimore , Weiying Gao , Weishi Wu , Ying Wang , Charles D McLaren
发明人： Jerald Feldman , Norman Herron , Michael Henry Howard, Jr. , Nora Sabina Radu , Vsevolod Rostovtsev , Kerwin D Dobbs , Adam Fennimore , Weiying Gao , Weishi Wu , Ying Wang , Charles D McLaren
CPC分类号： H01L51/0072 , C09K11/025 , C09K11/06 , C09K2211/1003 , C09K2211/1029 , C09K2211/1059 , C09K2211/185 , H01L51/0061 , H01L51/0067 , H01L51/0074 , H01L51/0085 , H01L51/0087 , H01L51/0558 , H01L51/5016 , H01L2251/5384 , H05B33/14
摘要： This invention relates to a composition including (a) a dopant, (b) a first host having at least one unit of Formula I, and (c) a second host compound. Formula I has the structure where Q is a fused ring linkage having the formula In Formula I: R1 is the same or different at each occurrence and is D, alkyl, aryl, silyl, alkoxy, aryloxy, cyano, vinyl, or allyl; R2 is the same or different at each occurrence and is H, D, alkyl, or aryl, or both R2 are an N-heterocycle; R3 is the same or different at each occurrence and is H, D, cyano, alkyl or aryl; and a is the same or different at each occurrence and is an integer from 0-4.
摘要翻译： 本发明涉及包含（a）掺杂剂，（b）具有至少一个式I单元的第一主体和（c）第二主体化合物的组合物。 式I具有结构式，其中Q为具有式I的稠环键。式I中：R 1在每次出现时相同或不同，为D，烷基，芳基，甲硅烷基，烷氧基，芳氧基，氰基，乙烯基或烯丙基; R2在每次出现时相同或不同，为H，D，烷基或芳基，或两者均为N-杂环; R 3在每次出现时相同或不同，为H，D，氰基，烷基或芳基; 并且a在每次出现时相同或不同，为0-4的整数。
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公开(公告)号：US5541319A
公开(公告)日：1996-07-30
申请号：US431809
申请日：1995-05-01
IPC分类号： C07D223/16 , A61K31/55 , A61P9/00 , A61P25/00 , A61P25/28
CPC分类号： C07D223/16
摘要： A method for the treatment of neurological disorders, comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I or of formula II (formulae set out on pages following the Examples), whereinR.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently selected from:hydrogen,(1-3C)perfluoroalkyl,halo, nitro and cyano;R.sup.5 is a (1-5C)alkyl group;or a pharmaceutically acceptable salt thereof.Also provided are compounds and pharmaceutical compositions suitable for the treatment of neurological disorders.
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